6238 papers
This cluster-randomised trial in Ghana demonstrates that five rounds of community-wide dihydroartemisinin–piperaquine mass drug administration significantly reduced malaria parasite prevalence by 94%, lowered reinfection risk, and improved haemoglobin outcomes in a moderate-to-high transmission setting without serious adverse events.
This nationwide ecological study reveals that AIDS incidence among older adults in Brazil increased significantly between 2001 and 2022, with pronounced regional disparities and spatial clustering that underscore the urgent need for targeted, age-specific prevention and healthcare strategies.
This study evaluates public awareness of newborn screening and hereditary disorders in India through a nationwide survey, revealing significant knowledge gaps that necessitate policy-driven strategies and targeted educational initiatives to improve early detection and reduce the long-term health burden.
This prospective cohort study of Chinese middle-aged and older adults reveals that persistent and worsening depressive symptom trajectories are associated with more than double the risk of developing incident cardiometabolic multimorbidity compared to low and decreasing symptom patterns.
This study demonstrates that puberty is associated with a significant and accelerated decline in kidney function (eGFR) among children with chronic kidney disease, including those with early-stage disease, a trend observed across both sexes and not solely attributable to pubertal changes in muscle mass.
This retrospective study demonstrates that a modified disposable surgical drape significantly outperforms conventional reusable cloth drapes in robotic radical prostatectomy by reducing weight, lowering costs by 49%, and eliminating peri-incisional bacterial contamination.
This prospective cohort study of 6,534 Chinese adults demonstrates that nine C-reactive protein-triglyceride-glucose index (CTI)-derived adiposity phenotypes are significantly associated with the risk of incident cardiovascular-liver-metabolic multimorbidity, with the CTI-BMI index showing the strongest and most robust predictive performance.
A cross-sectional survey of 82 primary care providers and endocrinologists reveals significant gaps in their ability to accurately interpret key elements of ophthalmology notes for diabetic retinopathy, highlighting the need for standardized documentation to improve inter-specialty care coordination.
ProToxNet is a novel framework that integrates proteome-wide drug–protein binding predictions with tissue-specific gene expression to accurately predict tissue-stratified adverse events for both known and novel drugs, demonstrating strong generalization and clinical validity across multiple benchmarks.
This retrospective cohort study of 865 hip replacement patients found that perioperative administration of acetate-buffered balanced crystalloid solution (SPMCG) was significantly associated with a reduced risk of postoperative myocardial injury within 3 and 7 days compared to non-SPMCG use.