📄 medicine

Permeation improvement and prolonged skin deposition of silymarin through shatdhauta ghrita cream: Formulation, dermatokinetic and anti-aging studies

This study demonstrates that formulating silymarin in a traditional Shatdhauta ghrita cream significantly enhances its skin permeation and deposition, prolongs its stability, and effectively exerts anti-aging effects by reducing oxidative stress markers while boosting antioxidant enzymes and collagen levels.

Moreshwar Patil, Madhuri Deshmukh2026-07-01
📄 medicine

Evaluating the Quantitative Perception of Residents of Paynesville City on the Excessive Alcohol Consumption among Adolescents and Youth

This pilot study utilizing a quantitative cross-sectional design and the FOAP framework reveals that residents of Paynesville City perceive excessive alcohol consumption among adolescents and youth as a significant and increasing public health challenge driven primarily by peer pressure and lack of parental control, necessitating urgent stakeholder intervention.

Forkpah Pewee, Cyrus N. Cooper2026-07-01
📄 medicine

Perceptions, Adoption, and Safe Water Handling Practices among Households in Borama District, Somaliland: A Community-Based Cross-Sectional Study

This community-based cross-sectional study in Borama District, Somaliland, reveals that while households possess high awareness of waterborne diseases and household water treatment methods, there is a significant gap between recognizing the importance of water treatment and consistently practicing it, highlighting the need for targeted education and training to improve sustained adoption.

yasin Ali, vitalis Okoth, Mirrium Mutuku2026-07-01
📄 medicine

Efficacy and Safety of Unilateral Biportal Endoscopy Compared with Percutaneous Endoscopic Interlaminar Discectomy for the Treatment of Lumbar Lateral Recess Stenosis: A Minimum 6-month Follow-up

This retrospective study of 156 patients with lumbar lateral recess stenosis demonstrates that while unilateral biportal endoscopy (UBE) and percutaneous endoscopic interlaminar discectomy (PEID) share similar perioperative profiles, UBE provides superior long-term leg pain relief, functional recovery, and patient satisfaction at 6-month follow-up with no recurrence cases compared to PEID.

Bo Hu, Moqiang Li, Ke Xiao, Xiangbing Zeng2026-07-01
📄 medicine

An SPP1+ Macrophage / GZMK+ CD8 T-Cell Axis Mediates Immune Escape and Defines a Therapeutic Target in Non-Small Cell Lung Cancer

This study identifies a specific SPP1+ macrophage and GZMK+ CD8+ T-cell axis in non-small cell lung cancer that drives immune checkpoint inhibitor resistance through spatial exclusion and signaling-mediated T-cell exhaustion, proposing a novel prognostic signature and therapeutic strategy to target this myeloid-lymphoid interaction.

zhejiong wang, Xiang Zhang, Chunbo Ma, Lichen Zhu, Yifei Wu, Ying Yu2026-07-01
📄 medicine

Trends in psychological distress and associated disability in the Australian working population (2001–2022)

Over the last two decades in Australia, high psychological distress and disability support pension rates for psychiatric conditions have diverged, with distress rising significantly among young women since 2011 while overall pension payments declined due to policy changes, though they recently increased for younger age groups.

Mark Deady, Richard W. Morris, Aliza Werner Seidler, Daniel AJ Collins, Peter Butterworth, Samuel B Harvey2026-07-01
📄 medicine

Effects of local tranexamic acid on bleeding during rhytidectomy and post operative complication: randomized, controlled, single-blind trial

This protocol outlines a single-blind, randomized controlled trial at King Abdulaziz University Hospital designed to evaluate whether adding local tranexamic acid to tumescent solution during rhytidectomy reduces bleeding-related complications compared to tumescent solution alone.

Abdulaziz Saud Alenazi, Ahmed M Alarfaj, Amani A Obeid, Abdulaziz Alrabiah, Osama Alkaoud, Abdulaziz Alderaywsh, Leena R (…)2026-07-01