📄 Category

medicine

6295 papers

📄 medicine

Knowledge, Attitudes, and Practices of Healthcare Providers in Addressing the Care Needs of Individuals who identify as LGBTQIA+ in Türkiye : Evidence from Implicit and Explicit Measures

This study of 278 Turkish healthcare providers reveals that while higher education, less experience, and personal contact with LGBTQIA+ individuals correlate with better self-reported knowledge and practices, a disconnect exists between these favorable explicit reports and underlying implicit biases favoring heterosexual and cisgender individuals, highlighting the need for comprehensive interventions to address both dimensions of bias.

Seda Karakaya Çataldaşᵃ, Joanna Anneke Rummensᵇ, Erin Zieglerᶜ, Esra Ummakᵈ, Cemile Hürrem Ayhanᵉ, Fahriye Oflazᶠ2026-07-01
📄 medicine

Prognostic Nutritional Index as a Graded Predictor of Short- and Long-Term Mortality in Patients with Pulmonary Hypertension: A Retrospective Cohort Study

This retrospective cohort study of 1,317 pulmonary hypertension patients using the MIMIC-IV database demonstrates that the Prognostic Nutritional Index (PNI) serves as an independent, dose-dependent predictor of both short- and long-term mortality, with higher PNI levels significantly associated with reduced risks of in-hospital, 30-day, and one-year death.

jinhua zhu, Zhenrong Ouyang, Junjun Li, Qingqing Chen, Shujing Yin, Yefei Lei, Yunbin Xiao2026-07-01
📄 medicine

Real-World Outcomes of First-line and Second-line Chemotherapy with Dabrafeniband Cetuximab in BRAF V600E-Mutant Metastatic Colorectal Cancer: The Preliminary Data from a Single Center

This preliminary single-center retrospective study of 22 patients suggests that the combination of dabrafenib, cetuximab, and chemotherapy is an effective and tolerable treatment for BRAF V600E-mutant metastatic colorectal cancer, demonstrating superior response rates when used as a first-line therapy compared to second-line.

Chenhan Zhong, Fengli Huang, Dan Li, Kai Jiang, Yan He, Ying Yuan, Shanshan Weng2026-07-01
📄 medicine

Venetoclax-combined Induction Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia: A Propensity Score-matched Analysis

This propensity score-matched analysis demonstrates that adding venetoclax to standard 3+7 induction chemotherapy significantly improves remission rates and event-free survival in newly diagnosed acute myeloid leukemia, while a modified 2+5+V regimen offers comparable efficacy with a potentially more favorable toxicity profile, particularly for older or less fit patients.

Qiaoyi Zhou, Hong Liu, Lihua Wu, Chunhua Liu, Xiyan Wang, Zhenzhen Wang, Lijun Fang, Yu Yang, Runxia Gu, Shangzhu Li, Sh (…)2026-07-01
📄 medicine

Neural Timescale of Adolescents Major Depressive Disorder

This study identifies widespread disruptions in intrinsic neural timescales as a core feature of adolescent major depressive disorder, linking these temporal instabilities to symptom severity, suicidality, and underlying neurobiological mechanisms involving neurotransmitter systems and gene expression.

Xiaobo Liu, Tengteng Fan, Yong Han, Sanwang Wang, Qiuxuan Yu, Hanliang Wei, Yujun Gao, Geng Liu, Xianwei Guo, Lang Liu (…)2026-07-01
📄 medicine

Survival and Pathological Outcomes of Neoadjuvant Therapy Plus Surgery versus Direct Surgery in CNLC Ib–IIIa Hepatocellular Carcinoma

This retrospective study demonstrates that preoperative neoadjuvant therapy significantly improves recurrence-free survival and reduces high-risk pathological features compared to direct surgery in patients with CNLC Ib–IIIa hepatocellular carcinoma undergoing R0 resection.

Shaowei Mu, Shuqing Wu, Tong Zhou, Yang Wang, Zhao Li, Jiye Zhu, Jie Gao2026-07-01
📄 medicine

Development and Validation of a Machine Learning-Based Clinical Prediction Model for Liver Metastasis in Stage III–IV Non-Small Cell Lung Cancer

This study developed and validated a Stacking ensemble machine learning model using six clinical predictors to accurately identify the risk of liver metastasis in patients with stage III–IV non-small cell lung cancer, demonstrating strong discrimination and calibration while offering an online calculator for potential clinical application.

Jin Gao, Yan-Yuan Du, Yu-Ming Liu, Hui-Bo Yu, Hong-Gang Zheng, Wei Hou2026-07-01
📄 medicine

Network Analysis of Depressive Symptoms and Activities of Daily Living Disability in Older Adults with Diabetes: A nationwide population-based study

Using nationwide data from 984 older Chinese adults with diabetes, this study employs network analysis to identify "feeling depressed" as the central symptom and specific functional and affective items as bridge nodes that drive the co-occurrence of depressive symptoms and activities of daily living disability, suggesting targeted interventions on these key symptoms could effectively mitigate comorbidity.

Dongrui Miao, Jiangyan Dong, Dong Song, Yanxia Guo, Yuqing Zhang, Jiaojiao Zhu, Ran Chen, Yuanling Xu2026-07-01
📄 medicine

The association between pre-pregnancy use of obesity medications and gestational weight gain: a retrospective cohort study

This retrospective cohort study reveals that pre-pregnancy use of obesity medications, particularly within six months of conception, is associated with a significantly increased risk of excessive gestational weight gain and adverse maternal and neonatal outcomes, underscoring the need for targeted preconception counseling and prenatal weight management strategies.

Helena Piccinini-Vallis, Janet Green, Kristyn Reeves, Megan Campbell2026-07-01
📄 medicine

Substance-Level Disproportionate Reporting of Impaired Gastric Emptying for Five Glucagon-Like Peptide-1 Receptor Agonists: A Reproducible Signal-Detection Analysis of the FDA Adverse Event Reporting System

This study utilizes a transparent, fully reproducible analysis of the FDA Adverse Event Reporting System to confirm a significant disproportionate reporting signal for impaired gastric emptying across five GLP-1 receptor agonists, while explicitly clarifying that these findings reflect reporting patterns rather than established clinical incidence or causality.

Igor Eduardo2026-07-01