medicine papers | Gist.Science

Effectiveness of the STEPPS Programme for Borderline Personality Disorder Traits, Depressive and Psychotic Symptoms, and Underlying Maladaptive Schemas among Japanese University Students: A Randomised Controlled Trial

This randomized controlled trial demonstrates that the STEPPS programme is an effective early intervention for Japanese university students, significantly reducing borderline personality disorder traits, depressive and prodromal psychotic symptoms, and maladaptive schemas while preventing the deterioration of these conditions compared to a waiting list control group.

Hitomi Terashima, Keisuke Yamada, Chisa Okubo, Asa Nagae, Takako Namatame, Yoshiaki Uno2026-06-30

📄 medicine

Freezing of Gait in Parkinson’s Disease: A Mixed-Methods Study of Patient Experience and Functional Burden

This mixed-methods study of 41 Parkinson's disease patients reveals that freezing of gait is a pervasive, context-dependent disruption of automatic movement that imposes significant physical and psychosocial burdens, necessitating patient-centered assessments and interventions that address both symptom frequency and the broader functional impacts on daily life.

Jennifer R. Mammen, Mirinda Tyo, Nami Shah, Jocelyn Silva, Mathew Stephen, Varun Reddy, Kaylena A Ehgoetz Martens, Moran (…)2026-06-30

📄 medicine

Design, Synthesis, and Mechanism of Novel Coumarin-Based Inhibitors of the Tryptophan-Kynurenine Pathway for Neuroinflammatory Depression

This study reports the design and synthesis of a novel coumarin-based dual IDO1/TDO inhibitor (Compound 10) that effectively alleviates neuroinflammatory depression in mice by modulating the tryptophan-kynurenine pathway, suppressing neuroinflammation, and restoring serotonin levels.

Hui Liu, Lina Hu, Shijia Yi, Zheshan Quan, Zheng Liu, Shiben Wang, Qingkun Shen2026-06-30

📄 medicine

Colon-Targeting pH-Responsive Bletilla striata Polysaccharide Coacervate Microdroplets for Ulcerative Colitis Therapy via Macrophage Reprogramming

This study develops a pH-responsive Bletilla striata polysaccharide coacervate microdroplet system that enables precise colon-targeted delivery to treat ulcerative colitis by reprogramming macrophage polarization, scavenging reactive oxygen species, repairing the mucosal barrier, and restoring gut microbiota homeostasis.

Qiantao Zhang, Lai Chai, Hui Liu, Xueer Hu, Yujing Niu, Hongli Cao, Xin Rao, Mingyuan Zhou, Yuchi Chen, Xiaoqing Ye, Fan (…)2026-06-30

📄 medicine

Laboratory test-ordering patterns carry an early prognostic signal in electronic health records

This study demonstrates that analyzing physician laboratory test-ordering patterns within the first 48 hours of hospital admission serves as a powerful early prognostic signal for adverse outcomes, achieving predictive performance comparable to models relying on actual measured laboratory and vital-sign values.

Shakuntala Baichoo, Ali Abedi, Barry Rubin, Bo Wang2026-06-30

📄 medicine

Efficacy of a Smart Injector for Dental Anaesthesia. A split- mouth study

This split-mouth study involving 30 volunteers demonstrates that the Smart Dental Injector significantly reduces pain perception and accelerates anesthesia onset compared to traditional syringes, without altering the duration of the anesthetic effect.

Ali Rokia, Mouetaz Kheirallah2026-06-30

📄 medicine

Papaverine mediated Anti-Inflatory and Analgesic Activities of Sauropus androgynus : Invitro Evaluation and Mechanistic Insights

This study investigates the anti-inflammatory and analgesic activities of *Sauropus androgynus*, with a specific focus on elucidating the mechanisms of its bioactive compound papaverine, which modulates key inflammatory pathways such as phosphodiesterase inhibition and cytokine signaling to support its potential as a multi-target therapeutic agent.

Senthamarai Selvi V, Dhanalakshmi J, Sheeladevi S2026-06-30

📄 medicine

CCL5 blockade reduces immunosuppression through control of SREBP-2 activity in glioblastoma

This study demonstrates that blocking CCL5 in glioblastoma remodels the tumor microenvironment and reduces immunosuppression by inhibiting SREBP-2 activity in macrophages and microglia, thereby enhancing the anti-tumor efficacy of temozolomide.

Ma Feng, LIU BIN, Zhou Ping, Xu Ying, Zheng Xing, Wang Hao, Si Qiang, Zhang Long, Jia Hang, Zhang Qiang, Sun Ting2026-06-30

📄 medicine

One-Year Clinical Outcomes of GPS Leukocyte-Rich Platelet-Rich Plasma Injection for Kellgren-Lawrence Grade II and III Knee Osteoarthritis: A Real-World Case Series

This retrospective real-world case series of 15 patients with Kellgren-Lawrence grade II or III knee osteoarthritis demonstrates that a single intra-articular GPS leukocyte-rich platelet-rich plasma injection significantly improved pain and quality of life at one year with high patient satisfaction and no serious adverse events, supporting its potential as a nonoperative alternative to delay or avoid surgery.

Hiroyuki Maeda, Takahiro Maeda, Mutsuhiro Maeda2026-06-30

📄 medicine

Partners, Bystanders, or Something in Between? Male Involvement, Misconceptions, and the Gendered Burden of Family Planning in Ghana

This qualitative study of couples in Greater Accra, Ghana, reveals that male involvement in family planning exists on a spectrum rather than as a binary of support or opposition, while highlighting significant gender disparities in contraceptive knowledge and the disproportionate physical and emotional burden women bear despite varying levels of partner engagement.

Freda Kuntu-Blankson, Emmanuel Omari Boakye, Daniel Akolbire Azure2026-06-30

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