📄 Category

medicine

6295 papers

📄 medicine

The Design, Delivery, and Workforce Composition of 30 Pilot Weight Management Services for Children and Young People in England

This paper analyzes the design, delivery, and workforce composition of 30 pilot weight management services for children and young people in England, revealing that while all services share core features and utilize multi-disciplinary teams, they exhibit significant local variation in eligibility criteria, staffing models, and care delivery to address severe and complex obesity.

Jordan Marwood, Paige Davies, James Nobles, Karina Kinsella, Jamie Matu, Rebecca Ann Stone, Tamara Brown, Daisy Forman (…)2026-06-30
📄 medicine

Prevalence and Associated Factors of Post-Anesthesia Care Unit Complications: A Multicenter Cross-Sectional Study in Ethiopia and Spain

This multicenter cross-sectional study conducted in Ethiopia and Spain reveals a 57.5% prevalence of post-anesthesia care unit complications, with neurologic and cardiovascular issues being most common, and identifies factors such as older age, comorbidities, higher ASA class, specific surgery types, and intraoperative blood transfusion as significant predictors while highlighting regional anesthesia as a protective factor.

Ataklti Adhanom Weldearegay, Angel Becerra-Bolanos, Sirak Worku Mekuanint, Kejela Edosa Keno, Badhaasaa Beyene, Teklay T (…)2026-06-30
📄 medicine

A Multifactorial Perspective on Adult Asthma Risk: Synthesizing Evidence on Smoking Behaviors, Sociodemographic Inequalities, and Environmental Exposures

This mini literature review synthesizes evidence from five studies to demonstrate that all forms of tobacco exposure, including electronic and heated products, significantly worsen asthma outcomes in adults, while emphasizing the critical importance of rigorous methodology and evidence-based smoking cessation strategies in clinical management.

Shendy Mirella Eka Febrianti, Moses Glorino Rumambo Pandin2026-06-30
📄 medicine

Baseline LDL-C Influences Achievement of Contemporary Lipid Targets Following Acute Coronary Syndrome: An Exploratory Secondary Analysis of a Randomized Trial

In an exploratory secondary analysis of a randomized trial involving statin-naïve Sri Lankan adults with acute coronary syndrome, while standard high-intensity statin therapy achieved moderate LDL-C targets in most patients, those with markedly elevated baseline LDL-C (≥130 mg/dL) rarely reached the stringent <55 mg/dL goal, suggesting a need for early treatment intensification in this high-risk subgroup.

Kavindya Fernando, Nilshan Fernando, Chiranthi Welhenge, BKTP Dayanath, Chamila Mettananda, Shamila De Silva2026-06-30
📄 medicine

Plasma proteome-wide Mendelian randomization with multi-layer triangulation identifies druggable targets for uterine leiomyoma

This study employs a comprehensive plasma proteome-wide Mendelian randomization framework with multi-layer triangulation to identify six genetically supported, druggable protein targets—including PARP1, RSPO3, and FSHB—that implicate Wnt, extracellular matrix, and hormonal pathways in the causal etiology of uterine leiomyoma.

Xin Wang, Guanglei Yao, Wei Ding2026-06-30
📄 medicine

Comparison of Thrombolysis with Endovascular Thrombectomy for Acute Ischemic Stroke: A Review of Recent Studies

This review synthesizes recent randomized controlled trials to conclude that endovascular thrombectomy is superior to thrombolysis alone for acute ischemic stroke, particularly in proximal large vessel occlusions and late treatment windows, while emphasizing the need for individualized care guided by advanced imaging and further research into long-term outcomes.

Benyamin Hosseinzadeh Shiraieh, Shadi Mahmoudi, Nima Safari, Iman Mollaei, Nariman Rahimi, Ehsan Ghaumzadeh2026-06-30
📄 medicine

Middle-aged, not the youngest, patients have the worst independent survival in ER-negative metastatic breast cancer: a retrospective cohort study

This retrospective cohort study reveals that while age does not significantly impact survival in ER-positive metastatic breast cancer, middle-aged patients (35–50 years) with ER-negative disease face the highest risk of death, an independent prognostic factor that persists even after adjusting for tumor proliferation markers like Ki-67.

Soo Ji Hong, Kyoung Eun Lee, Ahrong Ham, Janghee Lee, Hyun Goo Kim, Jun Woo Lee, Woosung Lim, Byung In Moon, Sei Hyun Ah (…)2026-06-30
📄 medicine

Symptom-specific multilevel response architectures of virtual reality analgesia in zoster-associated pain

This study demonstrates that while various virtual reality interventions (psychoeducation, mindfulness, and breathing training) similarly reduce pain and anxiety in adults with zoster-associated pain, the specific mechanisms driving symptom relief differ, with pain modulation linked to low gamma EEG changes and immersion, and anxiety reduction associated with theta-band EEG and heart rate variability.

Xu Liu, Bingxin Jiang, Yuhui Luo, Xiyuan Ba, Fengling Wu, Nan Li, Buyun Xiao, Yaqi Tang, Shengke Zhang, Changya Su, Lizu (…)2026-06-30
📄 medicine

Additive Predictive Value of the Sepsis ImmunoScore ® : A Multicenter, Prospective Evaluation of AI-Enabled Prediction of Sepsis Risk and Patient Outcomes 

This multicenter, prospective study demonstrates that the FDA-authorized, AI-enabled Sepsis ImmunoScore® significantly enhances clinician judgment by improving the discrimination and risk stratification of sepsis and critical care outcomes, effectively identifying occult high-risk patients who would otherwise be underestimated.

Akhil Bhargava, Carlos López-Espina, Lee Schmalz, Shah Khan, Gregory L. Watson, Robin Carver, Grace Staples, Lincoln Upd (…)2026-06-30