📄 medicine

Reduced Functional Exercise Capacity in Post-Tuberculosis Lung Disease: A Cross-Sectional Study in Uganda

This cross-sectional study of 213 recent pulmonary TB survivors in Uganda reveals that female sex, HIV co-infection, and productive cough are significant independent predictors of reduced functional exercise capacity, highlighting the need for targeted rehabilitation for these vulnerable subgroups.

Trang H.T. Quach, Damalie Nakkonde, Rosella Centis, Giovanni Battista Migliori2026-06-30
📄 medicine

A Late-Fusion Multilayer Perceptron and Logistic Regression Classifier Identifies a SETDB1-Linked Dual-Vulnerability Niche in Non-BRCA Pancreatic Ductal Adenocarcinoma

This study identifies a SETDB1-linked "Dual-Vulnerability Niche" in approximately 37% of non-BRCA pancreatic ductal adenocarcinoma patients characterized by high SETDB1 expression and backup DNA repair activity, demonstrating that combined SETDB1 inhibition and olaparib treatment effectively reduces tumor growth in preclinical models and validating a machine learning classifier capable of identifying this subgroup.

Aarush Shah2026-06-30
📄 medicine

Post-Orgasmic Enhancement of Attentional Focus in Adults with Attention-Deficit/Hyperactivity Disorder: A Cross-Sectional Survey Study

This cross-sectional survey of 93 university students with ADHD indicates that a significant majority experience a transient, statistically significant improvement in self-reported attentional focus within 15 to 90 minutes following orgasm, a phenomenon that appears more pronounced in unmedicated individuals and warrants further objective investigation.

Anzuman Ara Al Zannati2026-06-30
📄 medicine

Artificial Intelligence and Robotics in Neurosurgery: A Systematic Review of Performance, Validation Quality, and Translational Readiness

This systematic review of 56 studies (2015–2026) reveals that while AI, machine learning, and robotics demonstrate high performance in neurosurgical tasks like tumor detection and targeting, the field faces a significant translational bottleneck characterized by a high risk of bias, a lack of external validation, and a scarcity of prospective clinical trials, with robotic and adaptive systems showing greater readiness for clinical adoption than pure deep learning applications.

Krishnakumar Sankar, Hanessh Santhan Gopinath, Harish Santhan Gopinath, Shree Durga Muthukumar2026-06-30
📄 medicine

Determinants of Willingness-to-Pay for Mpox Vaccination in Indonesia

This cross-sectional study of 1,145 Indonesian respondents reveals that while Mpox awareness is high, willingness to pay for the vaccine is low and primarily driven by education, urban residency, prior STI history, and trust in health authorities rather than income or age, highlighting the need for targeted interventions to improve knowledge and accessibility.

I Made Subrata, Ngakan Putu Anom Harjana, Pande Putu Januraga2026-06-30
📄 medicine

Cognitive Load Shedding and Workflow Transformation: A Longitudinal Action Learning Study of AI Scribe Adoption in Residential Aged Care General Practice

This longitudinal action learning study of ten Australian GPs reveals that adopting AI scribes in residential aged care extends beyond efficiency gains to drive significant workflow redesign (the "Kaizen-to-BPR arc") and "cognitive load shedding," while simultaneously enhancing clinical communication and prompting collaborative solutions for complex consent challenges.

Jagdeesh Singh Dhaliwal, Riki Lane, Isabella Papadopoulos, Paresh Dawda, Gihan De Mel, Sian Hodgkinson, Lindsey S Hyde (…)2026-06-30
📄 medicine

Point-of-Care Ultrasound in the Diagnosis of Extensive Stanford Type A Aortic Dissection in a Low-Resource Setting: a case report

This case report documents the first successful use of emergency physician-performed point-of-care ultrasound (POCUS) to diagnose extensive Stanford Type A aortic dissection in a Ghanaian low-resource setting, highlighting both the diagnostic efficacy of the SPEED protocol for atypical presentations and the critical infrastructure gap preventing definitive surgical treatment.

Frederick Asamoah-Boachie, Emmanuel Amoah, Nessya Taylor, Kwabena Danso2026-06-30
📄 medicine

The systemic degree of inflammatory perturbation predicts unfavorable tuberculosis treatment outcomes

This retrospective cohort study demonstrates that the Degree of Inflammatory Perturbation (DIP), a composite metric derived from routine laboratory parameters, serves as an independent predictor of unfavorable tuberculosis treatment outcomes, offering a low-cost tool for early risk stratification and treatment monitoring.

Edson Beyker de Mendonça, Mariana Araújo-Pereira, Rodrigo Carvalho de Menezes, Caian L. Vinhaes, Flavia Marinho Sant’Ann (…)2026-06-30
📄 medicine

AI Chatbots and Conversational Agents for Health Communication in Low- and Middle-Income Countries: A Scoping Review of Applications, Outcomes, and Implementation Barriers

This scoping review synthesizes evidence from nine studies in low- and middle-income countries to demonstrate that AI chatbots and conversational agents effectively improve health knowledge and behavioral outcomes across various conditions, though their widespread implementation is hindered by digital inequities, language barriers, and a lack of rigorous clinical outcome assessments.

Anietie Akpan, Isaac Sandy, Oluwasegun Oloko, Alexander Ebubechi, Excellence Nwachukwu, Celestine Ilo, Margaret Timothy (…)2026-06-30
📄 medicine

Implementation of One Health Strategies for Prevention and Control of Priority Zoonotic Diseases in Ghana: A Systematic Review of Barriers, Facilitators, and Policy Gaps

This systematic review reveals that while collaborative networks and capacity building facilitate One Health implementation for zoonotic disease control in Ghana, the approach is significantly hindered by severe resource constraints, weak governance, and critical policy gaps, necessitating urgent systemic investments and a comprehensive national policy framework.

Joseph Oteng2026-06-30