📄 medicine

Redefining NSTE-ACS Risk Assessment: The Synergistic Power of CT-Enhanced GRACE 2.0 Score for Advanced Prognosis

This multicenter prospective study demonstrates that integrating coronary atherosclerosis plaque burden data from CT scans with the GRACE 2.0 risk score significantly enhances the long-term prognostic accuracy and risk stratification for patients with non-ST-segment elevation acute coronary syndrome compared to using the GRACE 2.0 score alone.

Jing-Wen Ma, Wei-Hua Yin, Shan Muhammad, Joseph Schoepf, Chuang-Shi Wang, Zhi-hui Hou, Yun-Qiang An, Er-Li Zhang, Yan Li (…)2026-06-29
📄 medicine

Risk Factors for Complicated Viridans Group Streptococcal Bacteremia in Adults: Impact of Oral Health

In a retrospective study of 164 adults with viridans group streptococcal bacteremia, community acquisition, odontogenic source, and *Streptococcus anginosus* group etiology were identified as independent predictors of complicated infection, highlighting the importance of early dental evaluation and imaging for these high-risk patients.

Kota Minami, Takashi Matono, Yusuke Oka, Toshiharu Urakami, Yosuke Aoki2026-06-29
📄 medicine

A Multidimensional Clinical-Functional Model of Cervicogenic Headache: Neck Disability, Pain Topography, and Treatment Response in a Multicentre Cohort

This multicentre study of 660 patients establishes a multidimensional clinical-functional model for cervicogenic headache, demonstrating that neck disability, pain topography, and treatment response are superior independent predictors of headache severity and diagnostic utility compared to cervical imaging findings alone.

Esra Aciman Demirel, Derya Uludüz, Damla Hazal Sucu, Nesrin Ergin, Burcu Karpuz Seren, Dilan Bayar Narin, Nevra Oksuz, A (…)2026-06-29
📄 medicine

Effect of donor age on release of bone morphogenetic protein in indigenously prepared demineralized freeze-dried bone allografts: An in vitro study

This in vitro study demonstrates that indigenously prepared demineralized freeze-dried bone allografts derived from younger donors (29–33 years) release significantly higher levels of BMP-7 compared to those from older donors (55–60 years), indicating that donor age is a critical factor influencing the osteoinductive potential of the graft material.

Nasreen Ansari, Arundeep Kaur Lamba, Farrukh Faraz, Shruti Tandon, Zainab Kamal, Zaid Kamal Madni, Archita Datta, Anshik (…)2026-06-29
📄 medicine

Maternal hypertension and cardiovascular medications dysregulate placental arterial tone

This study demonstrates that maternal hypertension and the use of various cardiovascular medications, including labetalol and bisoprolol, can dysregulate human fetoplacental vascular tone and reactivity, potentially compromising placental perfusion and fetal outcomes.

Teresa Tropea, Elizabeth C. Cottrell, Raianne Wallworth, Nardeen Khalil, Edward D. Johnstone, Jenny E. Myers, Paul Brown (…)2026-06-29
📄 medicine

Informed consent for digestive endoscopy in adults aged >85 years: documentation gaps and ethical implications

A retrospective study of adults aged ≥85 undergoing digestive endoscopy in Barcelona reveals significant ethical concerns regarding informed consent, characterized by frequent documentation gaps, a lack of process recording, and the absence of advance directives, particularly among those with cognitive or functional vulnerabilities.

MARTINA PELLICE, ANDREA LADINO, KAREN ARIANA CHAVEZ, MARTA ARROYO-HUIDOBRO, BRYAN SOLARI, ANA SUAREZ, ELENA ANGULO-ANTÚN (…)2026-06-29
📄 medicine

Host-Derived Immunometabolic Biomarkers Identify Prognostic Profiles under Immunotherapy in Advanced NSCLC: the SARC-LUNG Study

The SARC-LUNG study demonstrates that host-derived immunometabolic biomarkers, specifically sRAGE and FGF21, serve as prognostic indicators for survival outcomes and reflect distinct immune microenvironment profiles in patients with advanced non-small cell lung cancer treated with immune checkpoint inhibitors.

Andrea De Giglio, Maria Conte, Simona Coco, Francesco Galuppi, Sara Santamaria, Alessandra Rosa, Francesca Lo Bianco, Ma (…)2026-06-29
📄 medicine

Lupus myositis, a type I interferon driven necrotizing myopathy with regional heterogeneity

This study characterizes lupus myositis as a distinct type I interferon-driven necrotizing myopathy featuring perivascular mixed T and B cell inflammation and a "pan-fascicular" pattern, which can be reliably differentiated from other inflammatory myopathies using a combined immunohistochemical panel of MxA, MHC I, and MHC II.

Arpita Beechar, Bonnie Bermas, Chengsong Zhu, Changhong Xing, Jaya Trivedi, Salman Bhai, Joan S. Reisch, Veena Rajaram (…)2026-06-29