6308 papers
This Mendelian randomization study establishes that increased alcohol consumption frequency is a genetically supported, independent risk factor for generalized osteoarthritis, with plasma total cholesterol acting as a statistically significant but minor mediator in this causal pathway.
This study demonstrates that PD-L1 expression in thyroid carcinoma varies significantly across histological subtypes, being highest in anaplastic cases, and is strongly associated with aggressive clinicopathological features such as advanced tumor stage and extrathyroidal extension, suggesting its potential as a prognostic biomarker for guiding immune checkpoint therapies.
This study utilized electromyography to demonstrate that the anterior gluteus minimus and piriformis muscles on the weight-bearing side play distinct, critical roles in maintaining frontal plane pelvic control during single-leg standing, thereby offering new insights for the assessment and rehabilitation of pelvic stability disorders.
This study demonstrates that despite morphological similarities, thymic and pulmonary neuroendocrine neoplasms are driven by distinct molecular programs defined by anatomical origin and tumor grade, exhibiting divergent immune phenotypes, metabolic states, and pathway dependencies that support the development of site-adapted therapeutic strategies.
This study demonstrates that the Sonic DL deep learning reconstruction method enables highly accelerated, high-quality hepatobiliary-phase gadoxetate-enhanced MRI with a 12-second breath-hold, offering superior sharpness and reduced aliasing artifacts compared to conventional methods while maintaining diagnostic image quality.
Six months after successful macular hole surgery with ILM peeling, patients exhibited persistent, sector-specific reductions in retinal sensitivity that were significantly correlated with residual thinning of the macular structure and ganglion cell complex, highlighting the value of microperimetry in detecting functional deficits not captured by visual acuity alone.
This retrospective cross-sectional study conducted at Jigjiga University Sheikh Hassan Yabare Comprehensive Specialized Hospital in Ethiopia reveals a 29% preterm neonatal mortality rate, significantly associated with hypothermia, low birth weight, delayed feeding initiation, lack of kangaroo mother care, and preeclampsia.
This case report describes a 14-year-old boy who developed severe acute kidney injury and pulmonary infiltrates mimicking a pulmonary–renal syndrome following electronic cigarette use, which was ultimately diagnosed as vaping-induced acute tubular injury via kidney biopsy and resolved completely after discontinuing immunosuppression.
This study demonstrates that combining caspofungin with isavuconazole or amphotericin B significantly disrupts the architecture and metabolic activity of mature biofilms formed by various *Candida* species, offering a promising therapeutic strategy to overcome resistance associated with individual antifungal treatments.
This seven-year retrospective analysis of dengue fever in Yemen's Al-Hodeidah Governorate (2019–2025) reveals a high burden of disease with 115,381 suspected cases and a 27.9% laboratory confirmation rate, predominantly affecting males and young adults in winter, underscoring the urgent need for strengthened surveillance and targeted vector control amidst ongoing conflict and infrastructure challenges.