📄 Category

medicine

6374 papers

📄 medicine

Impact of Flipped Classroom Combined with Mini-CEX Formative Assessment on Core Competencies in Undergraduate Endocrinology Education: A Randomized Controlled Trial

This randomized controlled trial demonstrates that integrating a flipped classroom with Mini-CEX formative assessment significantly improves theoretical knowledge, clinical skills, self-directed learning, and critical thinking in undergraduate endocrinology education, despite resulting in a higher perceived study workload.

Langen Zhuang, Qianmin Ma, Shengqun Jiang, Xiaoyan Pei, Guoxi Jin, Qiong Xu2026-06-28
📄 medicine

Formulation and Evaluation of Tioconazole Liposomal Gel for Enhanced Topical Antifungal Activity

This study demonstrates that a tioconazole-loaded liposomal gel formulated with soy lecithin and cholesterol significantly enhances skin penetration, prolongs drug release, and improves antifungal efficacy against *Candida albicans* compared to traditional formulations, offering a promising therapeutic strategy for superficial fungal infections.

Arti Ingole, Hitanshi Darji, Ashwini Pansare, P.N. Sable2026-06-28
📄 medicine

Magnitude of uncontrolled type 2 diabetes and associated factors among adults attending Adama Hospital Medical College, Ethiopia

A facility-based cross-sectional study at Adama Hospital Medical College in Ethiopia found a high prevalence of uncontrolled type 2 diabetes (82.9%) among adults, which was significantly associated with factors including khat chewing, alcohol consumption, female gender, specific occupational statuses, and low intake of barley-based foods.

Haji Aman Deybasso, Abebe Megerso Adilo, Endashaw Abebe, Dejene Gemechu, Nura Gudeta2026-06-28
📄 medicine

Dose-Response Impact of Micropapillary Burden on Survival and Its Clinical Interaction with Surgical Extent in Lung Adenocarcinoma: A Propensity Score-Matched Competing Risks Analysis

In patients with lung adenocarcinoma containing micropapillary components, both higher micropapillary burden and sublobar resection independently predict worse survival and recurrence without a significant interaction between them, indicating that lobectomy should be preferred over sublobar resection regardless of micropapillary grade while aggressive adjuvant therapy is warranted for those with >40% micropapillary components.

Liang Zhou, Haitao Liu, junjie zhao, Fan Yang, Weibo Qi, Niu Niu2026-06-28
📄 medicine

Patient-specific antibiotic susceptibility ranking for empirical treatment of gram-negative bloodstream infection: a retrospective clinical decision-support and transportability study

This retrospective study demonstrates that a patient-specific antibiotic susceptibility ranking model significantly improves empirical active coverage for gram-negative bloodstream infections compared to clinician prescribing, primarily by recommending meropenem, though its external transportability is limited to drug-specific predictions rather than direct policy transfer.

Xiao Liu, Le Han, Wei Wang, Peng Xian, Yue Chang, Ying Liu, Lijun Ma, Jie Ren, Yunshuang Liu, Xiaosong Wang, Yujuan Long (…)2026-06-28
📄 medicine

Machine Learning–Based Lung Cancer Risk Prediction for Smokers and Non-Smokers Using National N3C Data

This study developed and evaluated interpretable machine learning models using national EMR data to predict lung cancer risk in both smokers and non-smokers, revealing distinct risk factor profiles for each group and offering a supplementary tool to improve early detection beyond current smoking-based screening guidelines.

Xing Liu, Saivachan Ponnapalli, Yannan LIN, Ya-Chen Tina Shih, Yu Liu2026-06-28
📄 medicine

Temporal Trends, Microbiological Characteristics, and Factors Associated with Healthcare- Associated Infections in Hospitalized Neurological Patients: An 8-Year Retrospective Study

This 8-year retrospective study of 45,166 neurological patients at Deyang People's Hospital reveals a significant decline in healthcare-associated infections from 3.5% to 1.1%, identifies lower respiratory and urinary tract infections caused by Gram-negative bacteria as primary challenges, and proposes an exploratory risk-estimation nomogram based on factors like age, comorbidities, and calendar year that requires further validation before clinical use.

Ying Yang, Shuai Jiang, Shiru Xiao, Li Luo, Ting Zhang, Xiaoyun Jiang, Yangyun Han2026-06-28
📄 medicine

Have we gotten better at diagnosing PDAC before it is too late?: Temporal Trends in Stage at Diagnosis of Pancreatic Ductal Adenocarcinoma in the United States

A retrospective analysis of US SEER data from 2004 to 2022 reveals a significant temporal shift toward earlier-stage diagnosis of pancreatic ductal adenocarcinoma, particularly for localized disease, likely driven by improved imaging and screening efforts, though further research is needed to confirm if this translates to improved survival.

Dina Hauptschein, Paul Kang, Surabhi Amar2026-06-28
📄 medicine

The Influence of Eye-Lip Interaction on Facial Attractiveness and Orthodontic Treatment Willingness: A Cross-Sectional Study

This cross-sectional study demonstrates that larger eyes significantly increase observers' tolerance for lip protrusion and reduce the perceived necessity for orthodontic treatment, with laypersons showing greater sensitivity to this eye-lip interaction than dental professionals.

Baodong Hao, Mingjin Zhang, Liang Lyu, Tingting Yu, Jiajing Li, Runzhi Guo, Dawei Liu2026-06-28
📄 medicine

Current status and influencing factors of online health information seeking behavior in elderly stroke patients based on latent profile analysis: a cross-sectional study

This cross-sectional study of 327 elderly stroke patients utilized latent profile analysis to identify three distinct subtypes of online health information-seeking behavior and determined that age, education, income, eHealth literacy, patient activation, social support, and self-efficacy are significant predictors of these behavioral patterns.

Jiale Wang, Yaqi Pang, ning Jin, Shuliang Chen2026-06-28