6374 papers
This study utilized whole-genome sequencing of purified Hodgkin and Reed–Sternberg cells from 76 patients to identify specific somatic copy number variations and mutational signatures linked to clinical outcomes, ultimately developing the TRACER-HL model to effectively stratify relapse risk in classical Hodgkin lymphoma.
This study demonstrates that an interpretable meta-analytical multi-task learning model utilizing the dynamic atherogenic index of plasma (AIP) outperforms traditional methods in predicting early cardiovascular-kidney-metabolic syndrome transitions in patients with NAFLD, establishing AIP as a superior predictive biomarker for proactive clinical risk interception.
This population-based observational study from a French prehospital system reveals a significant gap between protocol and real-world usage of ventilation feedback devices during out-of-hospital cardiac arrest, with only 28.9% utilization despite a mandate, while exploratory data suggest potential clinical benefits that warrant further investigation with robust implementation strategies.
In a retrospective study of 299 patients with surgically resected NSCLC brain metastases, seizures at presentation occurred in 25.1% of cases and were independently predicted by younger age, immunotherapy use, and absence of intracranial pressure symptoms, yet while seizure occurrence alone did not impact overall survival, a composite score incorporating seizure status along with age, tumor count, and immunotherapy use successfully stratified patients into distinct survival tiers.
This case report highlights primary labia minora fusion as a rare congenital malformation often overlooked despite causing functional obstruction and retrograde menstrual flow, advocating for early surgical reconstruction to prevent long-term complications like endometriosis and severe dysmenorrhea.
This case report describes the successful fertility-sparing management of a rare primary ovarian insular carcinoid tumor arising within a mature cystic teratoma in a 30-year-old infertile woman, demonstrating that careful staging and individualized treatment can yield excellent oncologic outcomes while preserving reproductive potential.
This mixed-method study in Luxembourg identifies a significant population of children with complex, life-limiting conditions who experience high healthcare utilization and unmet needs, demonstrating strong support from both families and pediatricians for establishing a specialized pediatric palliative care service to improve coordination, advance care planning, and reduce avoidable hospitalizations.
This study demonstrates that inhibiting STK19 with ZT-12-037-01 exerts potent anti-leukemic effects in Acute Myeloid Leukemia by suppressing NRAS-associated pro-survival signaling and inducing a PANoptosis-like inflammatory cell death program, thereby reducing tumor burden and prolonging survival in preclinical models.
This prospective echocardiographic study demonstrates that arteriovenous fistula creation in pre-dialysis chronic kidney disease patients induces early cardiopulmonary adaptation characterized by increased left ventricular volume loading, augmented cardiac output, and elevated pulmonary pressures while preserving systolic function, with proximal fistulas associated with a greater pulmonary hemodynamic burden.
This study demonstrates that Holmium Laser Enucleation of the Prostate (HoLEP) for mega glands (>200 mL) is not only safe with comparable short-term outcomes to large glands (120–200 mL) but also exhibits superior enucleation speed and energy efficiency, suggesting the procedure may be size-enhanced rather than merely size-independent.