3171 papers
This single-center quality improvement study demonstrates that a structured, physician-led educational intervention significantly enhances transition readiness, disease knowledge, self-management skills, and reproductive health awareness among adolescents with congenital heart disease.
This conceptual analysis argues that while existing biomedical appraisal tools effectively evaluate the technical soundness of study results, they fail to routinely verify whether the broader interpretations drawn from those results are actually supported by the specific comparisons the studies made, creating a critical gap between a result's validity and its application.
This study utilizing NHANES 2011–2018 data reveals that physically active US adults with prediabetes exhibit more diverse and strongly clustered cardiometabolic comorbidity patterns compared to their inactive counterparts, suggesting that physical activity fundamentally reshapes disease architecture rather than merely reducing prevalence.
This retrospective cohort study of 340 elderly hip fracture patients with perioperative atrial fibrillation reveals that the stress hyperglycemia ratio (SHR) exhibits a J-shaped nonlinear association with all-cause mortality and serves as an independent predictor that significantly enhances the prognostic accuracy of clinical models.
This case report details the complex clinical course and successful multidisciplinary management of a preterm infant with congenital cytomegalovirus infection who presented with severe neurological, hematological, hepatobiliary, cardiac, and ophthalmological complications, underscoring the critical importance of early diagnosis, coordinated specialist care, and long-term follow-up to optimize outcomes in this vulnerable population.
The paper introduces VIGIL, a validation-first research infrastructure that systematically extracts infectious disease intelligence from diverse open-source documents and continuously validates it against WHO reference data to quantify reporting biases and establish open-source signals as testable hypotheses rather than direct evidence.
This systematic review of 42 studies (2020–2026) characterizes the diverse spectrum of SGLT2 inhibitor-induced cutaneous adverse reactions, distinguishing between early-onset mild eruptions manageable with symptomatic treatment and delayed-onset severe immune-mediated or necrotizing conditions that require drug withdrawal and multidisciplinary intervention.
This case report describes a 32-year-old man with congenital agenesis of the left internal carotid artery, incidentally identified on trauma CT angiography by the absence of the bony carotid canal, highlighting the critical importance of distinguishing this rare anomaly from acquired occlusion to guide clinical management and future procedural planning.
In a multicenter retrospective study of 93 patients with HER2-positive metastatic breast cancer, Trastuzumab Deruxtecan achieved maximal tumor shrinkage at a median of 4.57 months, with minimal additional tumor burden reduction observed beyond 18 weeks, suggesting that treatment duration may be optimized by considering this timeframe for induction strategies.
In a pragmatic workplace setting where workers selected their preferred intervention, an 8-week high-intensity strength active-break program yielded superior improvements in physical function and muscular strength compared to a standard stretching program, while both approaches effectively reduced pain-related outcomes.