📄 medicine

Machine Learning-Based Diagnostic Model for Preoperative Anxiety in Elderly Patients with Hip Fractures and SHAP Analysis

This study developed and validated a CatBoost-based machine learning model using nine clinical features to accurately predict preoperative anxiety in elderly hip fracture patients, with SHAP analysis identifying pain levels, age, and comorbidities as key risk factors.

Qisheng Dou, Jiuying Liu, Qianyu Liu, Mingming Fu, Yuhang Liu, Meng Jin, Zhiyong Hou, Zhiqian Wang2026-07-15
📄 medicine

Why does Malaria Persist despite Control Interventions in Cameroon? A Multi-stakeholder Qualitative Study using the Social Ecological Model

This qualitative study utilizing the Social Ecological Model reveals that malaria persists in Cameroon due to a complex interplay of individual misconceptions, community-level socio-cultural and economic barriers, health system weaknesses, and policy implementation gaps, necessitating multi-sectoral and culturally sensitive interventions for effective control.

Valerie Makoge, Joelle Laure Sobngwi-Tambekou, Akindeh Nji, Gillian Stresman, Liwang Cui, Antonio Nkondjio, Innocent Ali (…)2026-07-15
📄 medicine

Endopelvic Fascia as a Surgical Landmark in Rectal Cancer: Continuity with the Obturator Fascia and Interfascicular Transition into the Rectum and Hiatal Ligament

This study clarifies that the endopelvic fascia is not an isolated membrane but a continuous connective tissue system linking the obturator fascia to the rectal wall and hiatal ligament, providing a crucial anatomical basis for defining surgical dissection planes in rectal cancer surgery.

Satoru Muro, Yuichiro Tsukada, Masaaki Ito, Akimoto Nimura, Keiichi Akita2026-07-15
📄 medicine

Clinical Correlates of Cognitive Impairment in Progressive Supranuclear Palsy and Multiple System Atrophy: A Comparative Neuropsychological Study

This comparative neuropsychological study of Indian patients reveals that Progressive Supranuclear Palsy (PSP) exhibits significantly greater global and domain-specific cognitive impairment than Multiple System Atrophy (MSA), with PSP cognition closely linked to motor and mood severity while MSA cognition appears more driven by cognitive reserve.

P M Athira, Keshav J Kumar, Shweta Prasad, Geethu T V, Manasi Harish, Saikat Dey, K Ravichandiran, Ayush Kataria, Shyam (…)2026-07-15
📄 medicine

Comparative Analysis of Trace Element and Heavy Metal Profiles in Gastrointestinal System Malignancies: Investigation of Clinical and Pathological Correlations via Microwave Digestion and ICP-MS Method

This prospective study utilized microwave digestion and ICP-MS to analyze trace element and heavy metal profiles in gastrointestinal tumor versus healthy tissues, revealing significant associations between specific elemental alterations (particularly Cd, Pb, Fe, and Zn) and clinicopathological factors such as neoadjuvant therapy and lymphovascular invasion, thereby suggesting their potential as onco-biomarkers for personalized oncology.

Ersin Uslu, Uğur Topal, Burak Yavuz, İshak Aydın, İsmail Cem Eray, Cihan Atar, Arbil Açıkalın, Sabriye Aydınoğlu Marinel (…)2026-07-15
📄 medicine

Moderate-to-late preterm birth, common respiratory pathogens, and severe lower respiratory tract infections across childhood

This study demonstrates that moderate-to-late preterm birth independently increases the risk of severe lower respiratory tract infections across childhood and exhibits a significant synergistic interaction with respiratory syncytial virus (RSV) that amplifies disease severity, despite not altering susceptibility to pathogen acquisition.

Xiaole Zhang, Lin Feng, Zongming Yang, Yongjian Huang2026-07-15
📄 medicine

Pulmonary surfactant-based inhalable nanoparticles for folate receptor- targeted delivery and macrophage reprogramming in lung cancer

This study demonstrates that inhaled pemetrexed-modified pulmonary surfactant nanoparticles loaded with paclitaxel (PEM-PSNP@PTX) effectively treat lung cancer by leveraging folate receptor-mediated dual targeting of tumor cells and macrophages to suppress tumor growth and reprogram the immunosuppressive microenvironment while minimizing systemic toxicity.

Kyungsu Kim, Eun Bi Jun, Byeong Hyeon Choi, Jun Hee Lee, Chang Geun Kim, Ji-Ho Park, Hyun Koo Kim2026-07-15
📄 medicine

Procedure-Related Uptake on CXCR4 PET/CT: A Frequent Pitfall Independent of Time and Anatomical Site

This study demonstrates that [68Ga]Ga-PentixaFor PET/CT frequently exhibits procedure-related uptake at surgical or interventional sites regardless of the time elapsed since the intervention or the anatomical location, highlighting a significant pitfall that correlates with [18F]FDG accumulation and may lead to false-positive interpretations.

Sebastian E. Serfling, Yingjun Zhi, Takahiro Higuchi, Philipp E. Hartrampf, Andreas K. Buck, Rudolf A. Werner2026-07-15
📄 medicine

Information loss in evidence synthesis: a meta-research study of exercise intervention reporting in randomized controlled trials and systematic reviews

This meta-research study demonstrates that systematic reviews of exercise interventions suffer from significant information loss compared to their source randomized controlled trials, primarily due to incomplete original reporting and further attrition during the synthesis process, particularly regarding equipment, adherence, provider characteristics, and tailoring methods.

Alexandra Maria Bodnaruc, David Moher2026-07-15