13473 papers
This study demonstrates that while both laparoscopic and robot-assisted radical prostatectomy are effective and safe for treating locally advanced pT3–4N0–1M0 prostate cancer, the robot-assisted approach offers a shorter operative time and superior early continence recovery.
This study demonstrates that a schema-aware, utility-gated maintenance strategy significantly improves the temporal calibration of a frozen prostate cancer survival model using SEER data, reducing prediction errors by 6.55% while preserving discriminative performance.
This in vitro study demonstrates that dual-energy CT material decomposition is a feasible method for quantifying albumin in various body fluids with high correlation to ELISA, particularly at concentrations of 17 mg/mL or higher, though fluid-specific calibration and further validation are required before clinical application.
This Phase II study from India demonstrates that high-dose ifosfamide (11 g/m²) offers substantial efficacy and durable disease control for patients with relapsed advanced synovial sarcoma, providing a vital therapeutic option in resource-limited settings despite significant toxicity and quality of life trade-offs.
This mixed-methods study of north-south migrants in Kumasi, Ghana, reveals that while physical access to healthcare facilities is high, utilization remains low due to financial constraints, inadequate National Health Insurance Scheme coverage, long waiting times, and cultural barriers, with usage patterns significantly influenced by gender, marital status, employment stability, and duration of stay.
This study develops a biodegradable yak-skin collagen/PMVE-MA composite for vascular stents that offers improved thermal stability and hemocompatibility but requires surface modification to overcome its inherent hydrophobicity, which currently hinders essential cellular adhesion and infiltration.
This nationally representative cohort study demonstrates that a machine learning-derived "hearing age gap," which captures the frequency-specific configuration of hearing loss rather than its overall severity, serves as an independent predictor of mortality risk beyond conventional audiometric measures.
This study of Florida census tracts reveals that while perceived social isolation exhibits significant spatial clustering, accounting for this spatial dependence renders differences between urban, suburban, and rural areas statistically nonsignificant, suggesting that public health strategies should prioritize localized hotspots over broad administrative classifications.
This study demonstrates that a phage display-based workflow successfully identified and validated highly specific TCRs targeting the KRASG12V neoantigen and CTAG1B cancer-testis antigen, which, when engineered into T cells, effectively suppressed colorectal and esophageal tumors in xenograft models with minimal off-target toxicity.
This qualitative multistakeholder case study reveals that professional identity significantly shapes how Irish stakeholders define and prioritize training capacity for postgraduate medical expansion, leading to the development of an Educational Readiness Framework that reconciles conflicting service, educational, and regulatory demands to ensure sustainable growth.