6374 papers
A 12-week structured rehabilitation program significantly improved gross motor function, as measured by the HFMSE, in children with Spinal Muscular Atrophy Types II and III, with the most substantial gains observed in younger participants.
The 2023 Adult Oral Health Survey reveals that periodontal disease and erosive tooth wear are highly prevalent among dentate adults in England, with both conditions increasing in severity with age and exhibiting significant inequalities, particularly for advanced cases.
This two-centre study demonstrates that while preoperative ¹⁸F-FDG PET/CT is highly specific and reliable for confirming lymph node metastasis in gynecologic cancer, its moderate sensitivity—particularly at the para-aortic and common iliac stations—means negative results cannot rule out disease, thus supporting its use to guide but not replace surgical nodal staging.
This study systematically evaluates cervical endplate bone quality (EBQ) in patients with ossification of the posterior longitudinal ligament (OPLL), revealing that OPLL patients exhibit significantly lower EBQ scores compared to other degenerative cervical myelopathy patients, alongside distinct variations by gender, vertebral level, and endplate position, with glucocorticoid history identified as the sole independent predictive factor.
This facility-based cross-sectional study in rural Sidama, Ethiopia, reveals that while a majority of women have heard of breast and cervical cancer, comprehensive knowledge, positive attitudes, and preventive practices remain critically low, with education level, age, and access to information identified as key determinants for better awareness.
This retrospective study of 101 patients with locally advanced esophagogastric junction adenocarcinoma undergoing transhiatal esophagectomy demonstrates that while the procedure yields acceptable oncologic outcomes, it is associated with substantial postoperative morbidity and mortality, with pathological stage, nutritional status, smoking history, and comorbidities identified as key predictors of survival and complications.
This retrospective cohort study of 41 CABG patients found no statistically significant differences in postoperative opioid consumption, pain scores, ICU length of stay, time to extubation, or QTc prolongation between those who received low-dose (<20 mg) versus high-dose (≥20 mg) intraoperative intravenous methadone.
This study identifies three distinct latent profiles of health-related quality of life among gastric cancer patients undergoing first postoperative chemotherapy and reveals that social support influences quality of life through a significant chained pathway involving resilience, fear of progression, and symptom experience, thereby supporting the need for personalized, integrated supportive care.
The ILANA study demonstrates that healthcare providers in England find the differentiated service delivery of long-acting injectable CAB + RPV in both clinic and community settings to be largely feasible, acceptable, and appropriate, provided that implementation prioritizes patient needs, equitable access, and provider ownership of the process.
This retrospective study identifies that older age, fewer subjective memory complaints, lower independence in instrumental activities of daily living, and specific cognitive deficits at the initial outpatient visit are key clinical characteristics associated with the subsequent conversion of mild cognitive impairment to dementia.