6374 papers
This retrospective study of 6,369 breast cancer patients demonstrates that while the reclassification rate of Variants of Uncertain Significance (VUS) in BRCA1, BRCA2, and PALB2 is low (3%), the process significantly impacts clinical decision-making by resolving uncertainty and guiding therapeutic strategies.
This study demonstrates that combining automated and hand-held breast ultrasound offers superior diagnostic specificity and a higher area under the curve compared to MRI for evaluating high-risk non-mass lesions, effectively reducing unnecessary biopsies while identifying key sonographic features predictive of malignancy.
This study demonstrates that analyzing dynamic 48-hour lactate trajectories in critically ill sepsis patients reveals distinct risk phenotypes and identifies a nonlinear mortality threshold at approximately 32.5% 24-hour lactate clearance, offering superior prognostic discrimination compared to static measurements and conventional severity scores.
In a prospective cohort of 900 patients with 2–4 cm renal stones, 18Fr suction mini-PCNL demonstrated comparable stone-free rates to standard PCNL while offering superior recovery outcomes (less pain, less bleeding, shorter stay, and lower fever), leading the authors to recommend it as a reasonable default option over individualized selection based on preoperative characteristics.
This case report describes the successful surgical resection of an exceptionally large (29.5 cm) retroperitoneal ganglioneuroma in a young man, highlighting the diagnostic challenges posed by its non-specific presentation and the feasibility of preserving vital organs despite the tumor's massive size.
This qualitative study of 16 primary care physicians in Singapore reveals that while they find video consultations for acute conditions convenient and acceptable, they face significant challenges regarding platform usability, increased administrative burdens, and safety concerns for elderly or complex patients lacking physical examinations.
This study demonstrates that combining Automated Breast Ultrasound System (ABUS) with conventional two-dimensional ultrasound significantly improves the preoperative differentiation of benign and malignant intraductal breast lesions, achieving a diagnostic accuracy (AUC of 0.90) superior to either modality used alone.
This qualitative study of 26 nursing managers in Iran identifies that capacity building is shaped by a value-creating context comprising family experiences, community developmental factors, and organizational conditions, suggesting that healthcare organizations should integrate these contextual influences into leadership development programs.
This cross-sectional study of 16,844 U.S. adults demonstrates that the combined Triglyceride-Glucose Index and Weight-Adjusted Waist Index (TyG-WWI) is a superior predictor of metabolic dysfunction-associated steatotic liver disease (MASLD) risk compared to either indicator alone, particularly among individuals with a lower BMI.
This case report demonstrates that a proactive, multidisciplinary rehabilitation approach involving coordinated physiotherapy and respiratory therapy enabled a critically ill 52-year-old LVAD recipient with severe ICU-acquired weakness, initially deemed unfit for intervention, to progress from complete immobility to independent ambulation and decannulation.