6374 papers
This study demonstrates that Thymoquinone (TQ) exerts anticancer effects on A549 lung cancer cells by inducing ROS-mediated apoptosis and downregulating the mRNA expression of STAT3 target genes, suggesting its potential as a therapeutic agent for lung cancer.
This study demonstrates that graded oral supplementation of vitamin C (100–1000 mg/kg) provides potent, dose-dependent hematoprotective and genoprotective effects against benzene-induced bone marrow failure, pancytopenia, and pre-leukemic changes in rats, with the highest dose effectively restoring blood parameters and reducing circulating blasts to near-control levels.
This systematic review of three studies published since 2023 reveals that while various complex methodologies have been applied to predict multiple long-term conditions, the field remains nascent and limited by high risk of bias, sub-optimal validation practices, and a lack of external validity, highlighting an urgent need for further rigorous investigation and methodological comparison.
This scoping review aims to synthesize global evidence to determine whether Post-Acute COVID-19 Syndrome (PACS) is more closely associated with the SARS-CoV-2 virus or COVID-19 vaccinations, utilizing the JBI protocol and PRISMA-ScR guidelines to analyze data from multiple major databases and health organizations.
This scoping review synthesizes evidence demonstrating that advanced spatial clustering methodologies reveal critical subnational inequalities in child stunting driven by WaSH determinants, arguing that shifting from national averages to high-resolution precision mapping is essential for optimizing targeted global health interventions.
This study presents a high-performance deep learning model using the METABRIC dataset that achieves a new benchmark in breast cancer recurrence prediction by attaining 100% precision, thereby demonstrating that sophisticated data engineering and network architecture can outperform complex multi-modal approaches even with limited clinical data.
This study of non-elderly adults in Matsudo City, Japan, found that while confounding by indication influenced early mortality patterns, all-cause mortality rates generally increased with the number of COVID-19 vaccine doses, even among proxy high-risk groups, suggesting that the observed trends are not fully explained by bias alone.
A facility-based cross-sectional study conducted in Dire Dawa, Eastern Ethiopia, found that nearly 30% of healthcare workers suffer from work-related low back pain, with significant risk factors including age over 40, work experience exceeding five years, prolonged standing, heavy lifting, alcohol consumption, and a lack of regular work breaks.
This scoping review of nine recent observational studies finds that prior incarceration in the United States is consistently associated with an elevated risk of cognitive impairment and poorer cognitive performance among community-dwelling adults, although these associations are often attenuated by factors such as educational attainment and premorbid cognition.
This interpretative phenomenological analysis of eight medical students and early-career doctors reveals that well-being is a dynamic, context-dependent concept often hindered by a "knowing–doing gap," leading participants to view artificial intelligence as a potential compensatory tool for navigating structural limitations in medical training.