6901 papers
This prospective randomized controlled pilot study suggests that cardiomyopeptidin (CMP) may significantly reduce the incidence of major adverse cardiac events and lower specific cardiac biomarkers in critically ill patients with myocardial injury, warranting further investigation into its therapeutic potential.
This randomized double-blind non-inferiority trial demonstrates that the combination of polymyxin B and minocycline is clinically non-inferior to polymyxin B plus high-dose sulbactam for treating carbapenem-resistant *Acinetobacter baumannii* ventilator-associated pneumonia, offering a viable therapeutic alternative in settings with prevalent sulbactam resistance.
This single-center retrospective study of 26 pediatric patients highlights that right-sided colonic diverticulitis is a rare condition with nonspecific symptoms often misdiagnosed as appendicitis, yet it generally presents with milder inflammation than complicated appendicitis and can be effectively managed with observation or conservative surgery to avoid unnecessary diagnostic pitfalls.
This study demonstrates that a machine learning model integrating DCE-MRI radiomics-based tumor habitat analysis with clinical variables can effectively and non-invasively predict three-class HER2 expression status in breast cancer, achieving a test set micro-average AUC of 0.865.
This comparative cross-sectional study reveals that dry eye disease secondary to chronic graft-versus-host disease exhibits more severe ocular surface damage, meibomian gland loss, and degraded visual quality than non-cGVHD dry eye, with specific transplant-related factors such as acute myeloid leukemia and haploidentical HLA matching serving as significant predictors of severity.
This retrospective study of 6,369 breast cancer patients demonstrates that while the reclassification rate of Variants of Uncertain Significance (VUS) in BRCA1, BRCA2, and PALB2 is low (3%), the process significantly impacts clinical decision-making by resolving uncertainty and guiding therapeutic strategies.
This study demonstrates that combining automated and hand-held breast ultrasound offers superior diagnostic specificity and a higher area under the curve compared to MRI for evaluating high-risk non-mass lesions, effectively reducing unnecessary biopsies while identifying key sonographic features predictive of malignancy.
This study demonstrates that analyzing dynamic 48-hour lactate trajectories in critically ill sepsis patients reveals distinct risk phenotypes and identifies a nonlinear mortality threshold at approximately 32.5% 24-hour lactate clearance, offering superior prognostic discrimination compared to static measurements and conventional severity scores.
In a prospective cohort of 900 patients with 2–4 cm renal stones, 18Fr suction mini-PCNL demonstrated comparable stone-free rates to standard PCNL while offering superior recovery outcomes (less pain, less bleeding, shorter stay, and lower fever), leading the authors to recommend it as a reasonable default option over individualized selection based on preoperative characteristics.
This case report describes the successful surgical resection of an exceptionally large (29.5 cm) retroperitoneal ganglioneuroma in a young man, highlighting the diagnostic challenges posed by its non-specific presentation and the feasibility of preserving vital organs despite the tumor's massive size.