6901 papers
This case report describes the successful fertility-sparing management of a rare primary ovarian insular carcinoid tumor arising within a mature cystic teratoma in a 30-year-old infertile woman, demonstrating that careful staging and individualized treatment can yield excellent oncologic outcomes while preserving reproductive potential.
This mixed-method study in Luxembourg identifies a significant population of children with complex, life-limiting conditions who experience high healthcare utilization and unmet needs, demonstrating strong support from both families and pediatricians for establishing a specialized pediatric palliative care service to improve coordination, advance care planning, and reduce avoidable hospitalizations.
This study demonstrates that inhibiting STK19 with ZT-12-037-01 exerts potent anti-leukemic effects in Acute Myeloid Leukemia by suppressing NRAS-associated pro-survival signaling and inducing a PANoptosis-like inflammatory cell death program, thereby reducing tumor burden and prolonging survival in preclinical models.
This prospective echocardiographic study demonstrates that arteriovenous fistula creation in pre-dialysis chronic kidney disease patients induces early cardiopulmonary adaptation characterized by increased left ventricular volume loading, augmented cardiac output, and elevated pulmonary pressures while preserving systolic function, with proximal fistulas associated with a greater pulmonary hemodynamic burden.
This study demonstrates that Holmium Laser Enucleation of the Prostate (HoLEP) for mega glands (>200 mL) is not only safe with comparable short-term outcomes to large glands (120–200 mL) but also exhibits superior enucleation speed and energy efficiency, suggesting the procedure may be size-enhanced rather than merely size-independent.
In a cross-sectional study of adults from the environmentally vulnerable Aral Sea region of Uzbekistan, the Triglyceride-Glucose (TyG) index was identified as a practical and significant marker for dysglycaemia, while elevated aminotransferases were linked to metabolic risk and thyroid dysfunction appeared more closely associated with central adiposity than with glycaemic status.
This European cross-sectional study reveals that erythropoietic protoporphyria significantly impairs patients' daily lives, work productivity, and emotional well-being due to frequent, severe photosensitivity reactions, underscoring the urgent need for early diagnosis and effective treatments.
This prospective observational cohort study of 230 children undergoing elective non-cardiac surgery found that overweight and obese patients have a significantly higher incidence of emergence delirium compared to their normal-weight counterparts, despite no observed differences in postoperative pain or behavioral changes.
This retrospective cohort study of 326 postpartum women with gestational diabetes mellitus identified pre-pregnancy BMI, excessive pregnancy weight gain, poor prenatal blood glucose control, insulin use, and advanced maternal age as independent risk factors for abnormal glucose tolerance 6–12 weeks after delivery, and successfully constructed a predictive model with an AUC of 0.82 to facilitate early clinical intervention.
This retrospective study suggests that preoperative triple inhalation therapy (LAMA/LABA/ICS) may reduce postoperative pulmonary complications in patients with non-small-cell lung cancer and emphysema, even among those with more severe underlying lung disease, without increasing adverse events.