6901 papers
This study developed and evaluated interpretable machine learning models using national EMR data to predict lung cancer risk in both smokers and non-smokers, revealing distinct risk factor profiles for each group and offering a supplementary tool to improve early detection beyond current smoking-based screening guidelines.
This 8-year retrospective study of 45,166 neurological patients at Deyang People's Hospital reveals a significant decline in healthcare-associated infections from 3.5% to 1.1%, identifies lower respiratory and urinary tract infections caused by Gram-negative bacteria as primary challenges, and proposes an exploratory risk-estimation nomogram based on factors like age, comorbidities, and calendar year that requires further validation before clinical use.
A retrospective analysis of US SEER data from 2004 to 2022 reveals a significant temporal shift toward earlier-stage diagnosis of pancreatic ductal adenocarcinoma, particularly for localized disease, likely driven by improved imaging and screening efforts, though further research is needed to confirm if this translates to improved survival.
This cross-sectional study demonstrates that larger eyes significantly increase observers' tolerance for lip protrusion and reduce the perceived necessity for orthodontic treatment, with laypersons showing greater sensitivity to this eye-lip interaction than dental professionals.
This cross-sectional study of 327 elderly stroke patients utilized latent profile analysis to identify three distinct subtypes of online health information-seeking behavior and determined that age, education, income, eHealth literacy, patient activation, social support, and self-efficacy are significant predictors of these behavioral patterns.
This study utilized whole-genome sequencing of purified Hodgkin and Reed–Sternberg cells from 76 patients to identify specific somatic copy number variations and mutational signatures linked to clinical outcomes, ultimately developing the TRACER-HL model to effectively stratify relapse risk in classical Hodgkin lymphoma.
This study demonstrates that an interpretable meta-analytical multi-task learning model utilizing the dynamic atherogenic index of plasma (AIP) outperforms traditional methods in predicting early cardiovascular-kidney-metabolic syndrome transitions in patients with NAFLD, establishing AIP as a superior predictive biomarker for proactive clinical risk interception.
This population-based observational study from a French prehospital system reveals a significant gap between protocol and real-world usage of ventilation feedback devices during out-of-hospital cardiac arrest, with only 28.9% utilization despite a mandate, while exploratory data suggest potential clinical benefits that warrant further investigation with robust implementation strategies.
In a retrospective study of 299 patients with surgically resected NSCLC brain metastases, seizures at presentation occurred in 25.1% of cases and were independently predicted by younger age, immunotherapy use, and absence of intracranial pressure symptoms, yet while seizure occurrence alone did not impact overall survival, a composite score incorporating seizure status along with age, tumor count, and immunotherapy use successfully stratified patients into distinct survival tiers.
This case report highlights primary labia minora fusion as a rare congenital malformation often overlooked despite causing functional obstruction and retrograde menstrual flow, advocating for early surgical reconstruction to prevent long-term complications like endometriosis and severe dysmenorrhea.