6901 papers
This paper introduces a "spring-plane" model demonstrating that even modest reductions in lumbar lordosis cause superlinear increases in anterior disc stress through coupled mechanical mechanisms, providing a quantitative rationale for preserving segmental lordosis to mitigate L4-L5 disc degeneration.
This study demonstrates that the BRAFV600E mutation confers cisplatin resistance in colorectal cancer by suppressing ferroptosis through the NF-κB/Lipocalin 2 signaling pathway, suggesting that restoring LCN2 expression could overcome this therapeutic resistance.
This paper presents VEN-1, a programmable hybrid nanobot platform combining DNA origami, nanocarbon resistance sensing, and magnetic propulsion to physically extract mutating viruses from host tissue upon reaching a specific binding threshold, offering a mutation-resistant therapeutic alternative to conventional antivirals.
This mixed-methods study of Community Led Complementary Feeding and Learning Sessions in three disaster-prone districts of Malawi reveals that while knowledge transfer enabled over 60% of households to sustain practices post-project, long-term continuity ultimately depends on addressing resource constraints, labor intensity, and the strength of community committees through localized resilience strategies.
This literature review synthesizes research on childhood adversity and sex-specific adolescent development to demonstrate how their interaction through shared neuroendocrine and inflammatory mechanisms creates distinct pathways for immune dysregulation and long-term health risks in males and females.
Using nationally representative data from the 2022 Somali Integrated Household Budget Survey, this study reveals that while overall substance use (khat, cigarettes, and shisha) in Somalia is low, it is sharply concentrated among working-age men, particularly those who are unemployed or divorced, whereas higher education and female sex serve as significant protective factors.
This observational study demonstrates that excessive daytime sleepiness significantly mediates inhibitory control deficits in patients with frontal lobe epilepsy, suggesting that improving sleep quality could serve as a non-invasive intervention to enhance cognitive outcomes.
This prospective observational study of 102 professional Brazilian K1 kickboxers found a high incidence of musculoskeletal injuries, primarily mild lower-limb contusions caused by roundhouse kicks, while utilizing Multiple Correspondence Analysis to map distinct clustering patterns between injury mechanisms, anatomical regions, and severity levels.
This quasi-experimental study demonstrates that a tailored e-learning intervention significantly reduced presenteeism among employees of a Swiss insurance company, though it failed to produce significant improvements in team health climate, supervision distrust, or musculoskeletal impairments, suggesting that individual-level training alone is insufficient for broader organizational change.
While telephone-based FES-I interviews show good agreement with face-to-face assessments for group-level comparisons in older adults, they yield significantly lower scores and are not equivalent for individual clinical decisions, particularly due to age-related differences and specific item variations.