6901 papers
This study demonstrates that non-invasive time-interferential stimulation (TIS) spatioselectively rescues neurons after ischemic stroke by disrupting the TRAF3-TBK1-NLRP3 axis to reprogram microglia from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype, thereby mitigating cerebral ischemia-reperfusion injury.
This prospective cohort study of 8,464 middle-aged and older Chinese adults demonstrates that higher cumulative C-reactive protein-triglyceride glucose index (cuCTI) and unfavorable longitudinal CTI trajectories are independently associated with an increased risk of incident cardiometabolic multimorbidity, with body roundness index partially mediating this relationship.
This cross-sectional study of 92 influenza-related videos on the Chinese version of TikTok during an epidemic season found that while overall content quality was moderate-to-high with news organizations outperforming physicians, user engagement metrics failed to predict quality, whereas video length and uploader follower count emerged as significant positive predictors.
This cross-sectional study of 126 colorectal cancer patients in China reveals that strong cancer fatalistic beliefs and advanced tumor stage are significant independent predictors of delayed health-seeking behavior, highlighting the need for targeted interventions to improve early detection.
This study from the SINAKO trial demonstrates that higher household HIV competence is significantly associated with greater acceptance and lower rejection of HIV as part of one's identity, highlighting the critical role of family support in shaping the illness experience of people living with HIV.
This study developed and preliminarily validated the Composite Deformity Score (CDS), a highly reliable five-parameter radiographic index that significantly correlates with osteochondral lesion severity and size in the talus, demonstrating strong predictive value and location-specific patterns that warrant further multicenter validation.
This study demonstrates that prophylactic treatment with cannabidiol (CBD) significantly mitigates local intestinal and systemic hepatic damage caused by ischemia-reperfusion injury in rats of different ages by reducing inflammation, oxidative stress, and apoptosis while preserving tissue architecture and function.
This study evaluates four paid large language models on parent-oriented pediatric laser dentistry questions, finding that while ChatGPT demonstrated the highest content quality and reliability, all models exceeded recommended readability levels and should serve only as educational supplements rather than replacements for professional dental consultation.
This study adapted the System Usability Scale to evaluate UgandaEMR+ across four Ugandan facilities, revealing moderate overall usability hindered primarily by operational friction such as cumbersome workflows, complexity, and inconsistency caused by infrastructure and support challenges rather than core software functionality.
This qualitative study of Iranian healthcare providers reveals that while sexual self-care is recognized as a vital component of primary care, its effective implementation is hindered by sociocultural taboos and structural deficiencies, necessitating comprehensive reforms in training, policy, and public engagement to empower providers and normalize sexual health services.