📄 medicine

Sociodemographic, Gender, and Regional Drivers of Comprehensive HIV and AIDS Knowledge and Testing Uptake among Indian Youth: Findings from Nationally Representative Survey

Using nationally representative NFHS-5 data, this study reveals that comprehensive HIV knowledge and testing uptake among Indian youth remain low and inequitable, with education, wealth, marital status, and geographic region identified as key determinants necessitating targeted, equity-focused interventions.

Joseph D. Williams, T. Ilanchezhian, V. Sampath Kumar, A. Vijayaraman, S. Chandrasekaran, P. Rajendra Prasad, R. Shanmug (…)2026-07-14
📄 medicine

Operative timing and patient-reported recovery in panfacial fractures: a retrospective cohort analysis of intermediate surgical delay at a government teaching hospital in northwestern India

This retrospective cohort study of 120 patients at a government teaching hospital in northwestern India demonstrates that panfacial fracture surgery delayed by 8–30 days due to bureaucratic procurement and scheduling barriers is independently associated with significantly inferior functional and aesthetic outcomes at 12 months compared to early intervention.

Chandrashekhar Chattopadhyay¹, Vikas Deo¹, Charu Chouhan¹, Mamta Patel¹, Priti Airun, Kamal Singh, Ayush Garg¹, Sugandha (…)2026-07-14
📄 medicine

Evaluating efficacy and safety of GVAX alone vs combinations in treatment of pancreatic adenocarcinoma; a single arm meta-analysis of Randomized Controlled trials

This single-arm meta-analysis of randomized controlled trials found no statistically significant improvement in overall survival or progression-free survival for patients with metastatic pancreatic adenocarcinoma treated with GVAX and CRS-207 vaccines, highlighting the need for larger, well-structured studies due to high heterogeneity and limited data.

Nabahat Shafi, Syeda Kashaf Batool, Arsalan Ahmed, Fatima Faisal, Hijab Furqan, Basant Ahmed Mahmoud, Hafiza Tooba Siddi (…)2026-07-14
📄 medicine

Quantification of Choroidal Blood Flow and Structure in High Myopia

This study utilized ultra-widefield SS-OCTA to demonstrate that high myopia induces marked spatiotemporal heterogeneity in choroidal remodeling, characterized by an early compensatory increase in choriocapillaris density followed by a significant, region-specific decline in vascular density and stromal volume alongside an increase in the choroidal stromal index.

Anqi Lei, Rui Li, Weiqun Hu, Zexu Wang, Chunmei Zou, Danna Zhang2026-07-14
📄 medicine

Current status and influencing factors of digital health literacy and health self-management ability of older adults with chronic diseases in China: a cross-sectional study

This cross-sectional study of 286 older Chinese adults with chronic diseases reveals that digital health literacy and health self-management abilities are at moderate levels and are significantly influenced by sociodemographic and internet usage factors, while also showing that subjective health ratings often fail to reflect actual disease prevalence.

Zhen Cheng, Ting Liu, Likun Luo, Shasha Jian, Xiaohong Huang, Yunhong Li, Li Sun, Zongtao Chen2026-07-14
📄 medicine

Intraday Location Variance as a Digital Marker for Mood Dynamics and Diagnosis in Bipolar and Major Depressive Disorders

This six-month longitudinal study demonstrates that time-segmented intraday location variance derived from passive GPS data serves as a valuable digital marker for distinguishing between bipolar and major depressive disorders and tracking mood dynamics, particularly through elevated morning mobility in bipolar patients and reduced evening mobility associated with severe depression.

Ting-Yi Lee, Ching-Hsuan Chen, Chih-Min Liu, I-Ming Chen, Hsi-Chung Chen, Shu-I Wu, Cheng-Dien Hsu, Chuhsing Kate Hsiao (…)2026-07-14
📄 medicine

An Automated Listener-Effort Measure for ALS Generalizes across Diverse Platforms and Protocols

This study demonstrates that a machine learning model utilizing speaking rate and transcription confidence can accurately and reliably predict Speech-Language Pathologist-rated Listener Effort across diverse ALS datasets, offering a scalable and efficient solution for remote speech monitoring and clinical trial endpoints.

Esteban G. Roitberg, Marcos A. Trevisan, Julian Peller, Federico Sevlever, Felipe Aguirre, Diego E. Shalom, Alan Taitz (…)2026-07-14
📄 medicine

Cultural adaptation of the EQ-5D-Y-5L into Amharic and Tigrinya languages in Ethiopia

This study successfully translated and culturally adapted the EQ-5D-Y-5L into Amharic and Tigrinya for use in Ethiopia, employing an iterative process of forward-backward translation, card-ranking, and cognitive interviews to ensure the resulting paper and digital versions are conceptually equivalent, comprehensible, and culturally relevant for children and adolescents.

Abraham G Welie, Elly Stolk, Laura Duncan, Mike Herdman, Feng Xie2026-07-14
📄 medicine

Effects of COVID-19 social restrictions on prevalence of age-related disorders and risk factor analyses: Evidence from a two-stage study

This two-stage study reveals that COVID-19 social restrictions in Japan were associated with increased rates of insomnia and hip fractures, decreased dyslipidemia, and identified reduced physical activity as a key modifiable risk factor for multiple adverse health outcomes among older adults.

Toshihiro Yamagata, Yasushi Terada, Munenori Nagao, Kaori Koyama, Atsuhiro Kanno, Katsutoshi Furukawa2026-07-14