📄 medicine

Contour-free multi-instance learning versus conventional CT features for preoperative Ki-67 stratification in gastric gastrointestinal stromal tumors: a retrospective comparison

This retrospective study of 61 patients found that contour-free complete-series multi-instance learning applied to dual-phase CT scans did not demonstrate a statistically significant discrimination advantage over conventional CT features for preoperative Ki-67 stratification in gastric gastrointestinal stromal tumors.

Bin Tian, Zeng Wang, Zhixia Chen, Jinge Zhang, Xin He, Yili Gu, Ke Zou, Jun Xie, Yu-Xuan Zhang, Xijiao Liu2026-10-19
📄 medicine

Investigating the inhibitory effect of β-sitosterol on liver fibrosis by modulating the p53/Caspase8/Caspase9/Caspase3 signaling pathway

This study demonstrates that β-sitosterol, a monomer component of *Polygonatum sibiricum*, ameliorates liver fibrosis by inducing apoptosis in LX-2 cells and suppressing fibrosis in CCl4-induced mice through the modulation of the p53/Caspase8/Caspase9/Caspase3 signaling pathway.

Yuxin zhang, Weitong Li, Yuting Fan, Haotian Shen, Bin Tang, Yilun Liu, Fengmei Deng, Li Cheng2026-10-19
📄 medicine

Early Childhood Caries Prevention Guidance for Parents in Canada: A Cross-Jurisdictional Analysis of Recommendation Consistency and Evidence Certainty

This cross-jurisdictional analysis of Canadian public health documents reveals that while provincial and territorial guidance on early childhood caries prevention for parents is largely consistent, the supporting evidence for these recommendations is predominantly of low to very low certainty, highlighting a need for standardized wording and a shared national template to address existing inconsistencies.

Karim Alomar, Lina Marin2026-10-19
📄 medicine

Hyponatremia as a prognostic indicator of mortality and complications in patients with cirrhosis: A Prospective Cross-Sectional Study

This prospective cross-sectional study of 160 cirrhosis patients in Syria demonstrates that hyponatremia (serum sodium ≤130 mEq/L) is significantly associated with greater disease severity, higher frequencies of major complications like hepatic encephalopathy and hepatorenal syndrome, and increased in-hospital mortality.

Yara Al-Amouri, Kenan Alshawish, Ibraheem Alfrouh2026-10-19
📄 medicine

Consumption of ultra-processed foods is positively associated with levels of pro- inflammatory cytokines in postmenopausal women: a cross-sectional study

This cross-sectional study of 565 postmenopausal women in Brazil reveals that higher consumption of ultra-processed foods is positively associated with elevated levels of pro-inflammatory cytokines, whereas greater intake of minimally processed foods correlates with reduced inflammation.

Giana Zarbato Longo, Danielle Cristine Guimarães da Silva, Fabrica Geralda Ferreira, Denise Maria de Lima e Silva Galvão (…)2026-10-19
📄 medicine

Apheresis Platelets Reduce De Novo HLA Antibody Formation After Heart Transplantation: Real World Data from a Retrospective Multicenter Study

This retrospective multicenter study of 223 heart transplant recipients demonstrates that intraoperative transfusion of apheresis platelets, compared to pooled platelet concentrates, is associated with a significantly lower risk of developing de novo HLA antibodies within one year, suggesting that preferential use of apheresis platelets may reduce alloimmunization and improve long-term outcomes.

Nicole Bewersdorf, Christine-Elena Kamla, Adrian Stephan, Carlotte Lachauer, Vincent Hettlich, Andrea Dick, Udo Boeken (…)2026-10-19
📄 medicine

Colour Shifts with pH: Investigating Anthocyanin as a Plaque-Disclosing Agent

This study demonstrates that anthocyanin, a natural pH-sensitive pigment, shows promise as a biocompatible plaque-disclosing agent for detecting cariogenic acidity at highly acidic levels, though its reliability decreases significantly at pH values above 5.0, indicating a need for further optimization before clinical use.

Panida Thanyasrisung, Nateeporn Suprakarn, Jidapha Surananthachak, Jeerus Sucharitakul, Palinee Detsomboonrat2026-10-19
📄 medicine

Pathways to improve the quality of clinical professional master’s degree theses: a retrospective analysis of double-blind review results

This retrospective analysis of 1,156 double-blind reviews for clinical professional master's theses reveals that while median scores remained stable, significant quality differentiation exists—particularly for equivalency-based students and in 2023's decline in practical value—necessitating targeted interventions in monitoring, supervision, and review processes to shift focus from formal compliance to substantive scholarly contribution.

Yijia Zhang, Linlin Wu, Zuobei Tang, Xinlu Li, Yanfeng Zhu, Fengmei Deng, Li Cheng2026-10-19
📄 medicine

Migration drivers, transition to practice, and workforce integration among Brazilian-educated nurses in the United States: A mixed-methods study

This mixed-methods study reveals that Brazilian-educated nurses migrate to the U.S. primarily for quality of life and professional growth, yet face significant challenges in language, bureaucracy, and clinical adaptation that necessitate extended, structured support beyond licensure to ensure successful workforce integration.

Isadora Blaschke da Silva, Bruno Gobato, Monique Haenscke Senna Schlickmann, Diovane Ghignatti da Costa, Elaine Cristina (…)2026-10-19
📄 medicine

Sociocultural Determinants of BMI-for-Age: Effects of Food Taboos, Cultural Beliefs, and Food Fallacies Among Adolescent Girls in Sokoto, Nigeria

Although food taboos, cultural beliefs, and food fallacies are highly prevalent among adolescent girls in Sokoto, Nigeria, this study found they do not significantly influence BMI-for-age, which instead is determined by age and education levels while revealing a double burden of malnutrition concentrated in early adolescence.

Khadijah Abdullahi Bagudu, fatima Yusuf, Abubakar Hadiza Anka, Ahmad Muhammad Yusuf, Hadiza Ishaq, Josiah Arhagba2026-10-19