📄 medicine

Integrated UPLC-MS/MS Metabolomics Reveals Novel Metabolic Markers for Type I Endometrial Carcinogenesis in Clinical Samples

This study utilized integrated UPLC-MS/MS metabolomics and transcriptomics on paired clinical samples to identify 436 differential metabolites and key pathways, such as ferroptosis and ABC transporters, that characterize Type I endometrial carcinogenesis and offer novel biomarkers for diagnosis and treatment.

Yachai Li, Jiarui Mi, Peixuan Wang, Meng Li, Liwei Yan, Yuanmei Deng2026-07-14
📄 medicine

Wealth-Related Inequity in the Co-occurrence of Obesity Hypertension and Diabetes in India from a Concentration Index Analysis of NFHS-6 2023-24

This study analyzes NFHS-6 (2023–24) data to reveal that while obesity and diabetes in India are strongly concentrated among the urban wealthy, hypertension is more equally distributed, suggesting a need for targeted fiscal interventions for metabolic risks and universal screening for blood pressure control.

Arul Murugan, Shobana S2026-07-14
📄 medicine

A Cross-Sectional study to assess the Attitudes of Health Care Providers (HCPs) about Maternal Health Promotion: Insights from Sultanpur City

This cross-sectional study of 300 Anganwadi Workers in Sultanpur City reveals that while the majority hold positive attitudes toward maternal health promotion, significant disparities exist based on rural versus urban postings and work settings, highlighting the urgent need for targeted capacity-building interventions to ensure equitable service delivery.

Sneha Srivastava, Ritu K. Sureka2026-07-14
📄 medicine

Guben Antai Decoction Inhibits M1 Macrophage Polarization via the NF-κB/HIF-1α Pathway: A Mechanistic Study on the Treatment of Recurrent Spontaneous Abortion

This study demonstrates that Guben Antai Decoction (GBAT) treats recurrent spontaneous abortion by inhibiting M1 macrophage polarization and suppressing the NF-κB/HIF-1α signaling pathway, thereby restoring trophoblast migration and invasion capabilities.

Xin Du, Bingyao Yang, Xin Zhang, Xuebing Li, Qingqing Wang, Qiqi Fu, Guilin Li, Dong Wu, Chunxia Wang, Yongwei Li2026-07-14
📄 medicine

Intra- and inter-rater reliability of spinopelvic measurements in functional positions for total hip arthroplasty

This study demonstrates that Spino-Pelvic Tilt and Sacral Slope offer superior intra- and inter-rater reliability compared to Anterior Pelvic Plane tilt for assessing pelvic tilt in functional positions during total hip arthroplasty planning, leading to a recommendation to prioritize the former two measurements.

Dirk van Bavel, Isaac Rhee, Andrew Kurmis, Ryan Quarrington, Lucian Bogdan soloman2026-07-14
📄 medicine

A Comparison of Pathogen Culture and Metagenomic Next-Generation Sequencing in Periprosthetic Joint Infections and Implications for Empirical Antibiotic Selection: An 9-Year Retrospective Study

This nine-year retrospective study of 407 periprosthetic joint infection patients demonstrates that metagenomic next-generation sequencing (mNGS) significantly outperforms traditional culture in detection rates and identifying mixed infections, thereby enabling more precise empirical antibiotic selection through the integration of mNGS data with susceptibility-based predictive models.

Haibo Sun, Tao Zhang, Zheng Su, Rui Zhang, Xianli Hu, Zhen Pang, Yao Luo, Chen Zhu2026-07-14
📄 medicine

Spatiotemporal hotspots of neonatal and child mortality in Nyeri County, Kenya, 2018–2025

This retrospective spatio-temporal analysis of Nyeri County, Kenya (2018–2025), reveals that under-five mortality is significantly clustered in specific wards, particularly among neonates, with persistent hotspots in Ruring'u, Kiganjo/Mathari, and Rware that warrant prioritized public health interventions.

Aloise Gikunda, Yvonne Opanga, Nelson Muriu, Meshack Ndirangu, Anthony Waruru, Anne Gitimu, Paul Maleya, Brian Okada, Jo (…)2026-07-14
📄 medicine

Dynamic CEA trajectories predict survival for non-metastatic colon cancer: development and validation of a combined prognostic model

This study developed and validated a combined prognostic model incorporating dynamic CEA trajectory classifications, demonstrating that integrating longitudinal CEA monitoring with clinicopathological factors significantly improves survival prediction for patients with non-metastatic colon cancer compared to traditional static models.

Yiyun Hu, Yimin Wu, Junbo Yuan, Dening Ma, Shunv Cai2026-07-14
📄 medicine

A Longitudinal Study on Predicting Quality of Life in T3 Stage Radiotherapy Patients Based on Ensemble Learning and SHAP Interpretation

This longitudinal study developed and validated a robust Stacking ensemble learning model with SHAP interpretation to accurately predict the quality of life of patients with abdominal malignant tumors three months after radiotherapy, identifying key modifiable determinants and their clinical thresholds to guide precision rehabilitation interventions.

Yanze Shi, Jiayin Liu, Yu Tian, Wei Zheng, Hui Li2026-07-13