816 papers
This study reveals that *Staphylococcus aureus* utilizes a refunctionalized, high-affinity acyl-CoA synthetase called MbcS to scavenge branched-chain fatty acid precursors under nutrient-limited conditions, thereby conferring a critical fitness advantage during intra-species competition.
This study evaluates the growth and enzymatic characteristics of 28 wild-type *Yarrowia lipolytica* strains isolated from diverse global environments to identify optimal candidates for industrial and food-related applications, highlighting strain SWJ-1b as a superior performer.
This study characterizes the largely unexplored diversity of seed-associated yeasts across nine plant species, revealing that the seed microbiome is dominated by diverse Basidiomycota (particularly Tremellomycetes) rather than Ascomycota, and confirming these taxa as core members of the seed microbiome with significant potential for agricultural applications.
This study presents the Macrogenetic Atlas of Prokaryotes (MAP), a comprehensive resource integrating genomic, population, phylogenetic, and ecological data from thousands of species to reveal how selection-driven mechanisms, such as genetic linkage and epistasis, shape prokaryotic diversity and evolutionary dynamics.
This paper presents a targeted cryo-FIB lift-out workflow that enables the preparation of thin lamellae from vitrified bacteria interacting with titanium nanopillars, facilitating high-resolution cryo-electron tomography to investigate bactericidal mechanisms under native hydrated conditions.
This study identifies the novel fluoroquinolone resistance gene *qrtA* on mobile pELF-type linear plasmids circulating in environmental *Enterococcus* and *Vagococcus* populations in Vietnam, revealing a likely evolutionary pathway from *Vagococcus* chromosomes to clinically relevant enterococci and highlighting the early stages of this gene's global dissemination.
This study proposes that the oral microbiome serves as a practical, non-invasive proxy for estimating enteric methane emissions in grazing livestock, offering a scalable alternative to invasive rumen sampling for breeding low-emission cattle.
This study demonstrates that *Phytophthora agathidicida* DNA is predominantly concentrated in the top 10 cm of kauri forest soil, supporting a shift to shallower sampling protocols that enhance detection sensitivity while minimizing disturbance to fragile root systems.
This paper introduces MODIFI, a novel software tool that detects DNA modifications in metagenomes to successfully link extrachromosomal genetic elements to their specific host strains, thereby overcoming previous scale limitations and enabling new insights into microbial epigenomics.
This study demonstrates that the human commensal bacterium *Enterococcus faecalis* undergoes rapid within-host evolution to metabolize the diet-derived nutrient fructoselysine, thereby depleting this resource and conferring robust colonization resistance against *Salmonella* infection through a conserved, diet-dependent mechanism.
This study identifies phosphoserine aminotransferase (SerC) as an essential metabolic checkpoint and promising drug target in *Mycobacterium tuberculosis*, demonstrating that its disruption severely impairs bacterial growth and intracellular survival by rewiring central carbon and nitrogen metabolism.
This study demonstrates that the ribosomal silencing factor RsfS is essential for *Helicobacter pylori* to survive in low-growth states, form biofilms, and establish chronic infection in the host.
This study demonstrates that human papillomavirus infection initiates with a rapid, actin-dependent transfer of heparan sulfate-coated virions from the extracellular matrix to the entry factor CD151 on the cell surface, a critical early step that precedes the slower, asynchronous internalization driven by glycan and capsid processing.
This study demonstrates that fractionated Moringa oleifera seed extracts exhibit polarity-dependent bioactivity, with polar aqueous fractions showing moderate antiplasmodial effects against Plasmodium falciparum and moderately polar organic fractions displaying robust, bactericidal activity against multidrug-resistant bacterial strains, highlighting the plant's potential for integrated infectious disease management.
This study demonstrates that a novel UVC-LED disinfection system effectively achieves 100% decontamination of complex transvaginal ultrasound probe surfaces, including difficult-to-reach areas, by eliminating diverse clinical microorganisms and achieving a >6.7 log10 reduction of Bacillus subtilis spores within 90 seconds.
This study demonstrates that fecal microbiota transplantation from donors preconditioned with a plant-protein diet enhances therapeutic efficacy in alcoholic liver disease by enriching specific gut bacteria to produce caproic acid, which activates the PPARα signaling pathway to improve hepatic lipid metabolism and restore gut barrier integrity.
This study analyzes IgE profiles and gut microbiome data from 508 adults to identify specific microbial families and metabolic groups associated with allergic sensitization, revealing distinct bacterial enrichments and depletions despite a lack of overall diversity differences between sensitized and non-sensitized individuals.
This study demonstrates that specific residues (D308 and A310) in the Domain III of the Powassan virus envelope protein determine its neurovirulence and lethality, and that mutating these residues creates an attenuated virus that fails to cause neurological disease in mice while still eliciting a protective immune response, offering a promising strategy for vaccine development.
This study reveals that multidrug-resistant *Enterococcus faecalis* strains from healthy Brazilian piglets have rapidly adapted to industrial antibiotic pressure by accumulating diverse mobile genetic elements, including large chromosomal resistance blocks and mosaic plasmids, which actively enhance agricultural fitness despite varying CRISPR functionalities.
This study demonstrates that bacteria utilize adhesive structures like type 1 fimbriae to form protective microcolonies that shield both adhesive and non-adhesive cells from contact-dependent competition, thereby preserving phenotypic heterogeneity within the community.