228 papers
Neurology explores the intricate workings of the brain and nervous system, tackling everything from memory and movement to complex conditions like epilepsy and Alzheimer's. This field seeks to understand how our minds function and what happens when that delicate machinery falters, aiming to improve lives through better diagnosis and treatment.
At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category, offering both straightforward plain-language explanations and detailed technical summaries so you can grasp the science at your own pace. Below are the latest papers in neurology, ready for you to explore.
This longitudinal analysis of propensity score-matched cohorts from the Parkinson's Progression Markers Initiative reveals that while alpha-synuclein positive LRRK2-PD patients exhibit milder baseline motor symptoms and dopaminergic deficits compared to sporadic PD, their four-year clinical progression trajectories are statistically similar.
This study demonstrates that using symptom-label permutation as a null model in lesion network mapping preserves anatomical specificity and controls type I error, thereby enabling the reliable identification of distinct brain networks underlying specific neurobehavioural deficits across a large multicenter stroke dataset.
This post hoc analysis of the ORIGINAL clinical trial demonstrates that tenecteplase (0.25 mg/kg) is a safe and effective alternative to alteplase (0.9 mg/kg) for treating patients with minor acute ischemic stroke, showing comparable rates of functional independence at 90 days and no significant differences in safety outcomes.
This study demonstrates that in chronic stroke survivors undergoing high-dose neurorehabilitation, stronger movement-related beta-activity serves as a neurophysiological marker specifically associated with improvements in real-world upper limb activity rather than impairment-level deficits.
This study identifies distinct peripheral blood immune signatures in primary tauopathy patients, revealing that a dysregulated axis characterized by impaired monocyte maturation and reduced Treg activity correlates with increased neurodegeneration, cognitive decline, and poorer prognosis, suggesting these cell subsets as potential biomarkers and therapeutic targets.
This study suggests that females' inherent verbal memory advantages may mask early Alzheimer's symptoms, leading to a delayed onset of cognitive decline despite amyloid pathology, which ultimately results in a steeper decline once dementia manifests and highlights a critical window for earlier detection and intervention.
This study demonstrates that combining standardized upper-limb tasks with interpretable sEMG feature analysis significantly improves the classification of early-stage Parkinson's disease by capturing complementary motor impairments related to bradykinesia, rigidity, and tremor.
This study demonstrates that ischaemic stroke survivors exhibit significant, dynamic, and region-specific reductions in MRI-detected perivascular space volume and cluster counts compared to healthy controls by 36 months post-stroke, suggesting a potential link between stroke and altered cerebral small vessel disease markers over time.
This longitudinal study demonstrates that obstructive sleep apnea is associated with enlarged MRI-visible perivascular spaces, which show a trend toward normalization and reduced statistical significance between patients and controls after 12 months of CPAP therapy, suggesting potential regional reversibility of this brain fluid transport marker.
This study identifies the upregulation of the DDR2 receptor in specific brain cells as a key driver of Alzheimer's disease neurovascular dysfunction and demonstrates that a brain-persistent antibody targeting DDR2 for degradation restores fluid dynamics and metabolic clearance, thereby reversing pathologies and rescuing cognitive deficits in mouse models.