🧠 Category

neurology

228 papers

Neurology explores the intricate workings of the brain and nervous system, tackling everything from memory and movement to complex conditions like epilepsy and Alzheimer's. This field seeks to understand how our minds function and what happens when that delicate machinery falters, aiming to improve lives through better diagnosis and treatment.

At Gist.Science, we make the latest research from medRxiv accessible to everyone. We process every new preprint in this category, offering both straightforward plain-language explanations and detailed technical summaries so you can grasp the science at your own pace. Below are the latest papers in neurology, ready for you to explore.

🧠 neurology

MRI-Perivascular Spaces in Chronic and Episodic Migraine Disorder

This retrospective study of 90 participants reveals that, contrary to the initial hypothesis linking migraine frequency to increased perivascular space (PVS) burden, migraineurs actually exhibited significantly lower PVS volumes and cluster counts compared to healthy controls, with the most pronounced reductions observed in individuals with aura, suggesting that aura rather than the disorder itself drives these glymphatic system alterations.

Pham, W., Rim, D., Jarema, A., Chen, Z., Khlif, M. S., Meylakh, N., Stark, R. J., Brodtmann, A., Macefield, V. G., Hende (…)2026-03-26
🧠 neurology

Pathology and genetics in a global cohort of Parkinsonian Disorders

This multicenter retrospective study of 3,353 brain donors across 11 global brain banks reveals that misdiagnosis rates for parkinsonian disorders range from 10% to 20%, with significant associations found between specific genetic variants (GBA1, LRRK2), ancestry (South Asian and Ashkenazi Jewish), and distinct pathological burdens, underscoring the critical need for biologically informed diagnostic tools and genetically stratified approaches in future therapeutic trials.

Wu, L. Y., du Toit, T., Georgiades, T., Stafford, E. J., Levine, K., Fang, Z. H., Jasaityte, S., Gil Martinez, A.-L., Cu (…)2026-03-26
🧠 neurology

Altered Saccades, Pupil, and Blink Responses in Functional Motor Disorder: Insight into Neurobiological Mechanisms

This study demonstrates that patients with Functional Motor Disorder exhibit distinct oculomotor abnormalities, including increased saccade errors, altered blink patterns, and reduced pupil dilation velocity, which are linked to symptom severity and support neurobiological models involving altered predictive and attentional processing in the frontal cortex and basal ganglia.

Sutorova, K., Riek, H. C., Pitigoi, I. C., Brien, D. C., Krupkova, B., Novakova, L., Sieger, T., Munoz, D. P., Serranova (…)2026-03-26
🧠 neurology

Neutrophil-to-Lymphocyte Ratio Predicts Infusion-Site Skin Nodules in Parkinson Disease Patients Receiving Foslevodopa/Foscarbidopa Subcutaneous Infusion

This study demonstrates that a higher baseline neutrophil-to-lymphocyte ratio (NLR) serves as a predictive biomarker for the development and persistence of infusion-site skin nodules in Parkinson's disease patients receiving foslevodopa/foscarbidopa subcutaneous infusion, while multidisciplinary surveillance effectively mitigates treatment discontinuation despite these adverse events.

Contaldi, E., Magistrelli, L., Piazza, S., Caniglia, A., Mainardi, E. A., Giametta, P., Pezzoli, G., Isaias, I. U., Lazz (…)2026-03-26
🧠 neurology

Therapeutic Efficacy and Safety of Deep Brain Stimulation for Multiple Sclerosis Related-Tremor: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis of 13 studies involving 131 patients indicates that Deep Brain Stimulation provides a significant reduction in tremor severity for individuals with medication-refractory Multiple Sclerosis, although the evidence is limited by small sample sizes and heterogeneity, with manageable risks including a 7% postoperative infection rate.

Fahim, F., Farajzadeh, M., Hosseini Marvast, S. M., Faramin Lashkarian, M., Khalili Dehkord, A., Sangtarashha, P., Qahre (…)2026-03-25
🧠 neurology

Naming Performance in Bilinguals with Alzheimer's Disease and Mild Cognitive Impairment

This study reveals that while active Catalan-Spanish bilinguals generally exhibit faster naming latencies than passive bilinguals, those with Mild Cognitive Impairment demonstrate a distinct pattern of increased cross-language intrusions and anomia, whereas passive bilinguals with MCI and Alzheimer's Disease show more semantic errors, highlighting the complex influence of second language use on lexical retrieval in clinical populations.

Sainz-Pardo, M., Hernandez, M., Suades, A., Juncadella, M., Ortiz-Gil, J., Ugas, L., Sala, I., Lleo, A., Calabria, M.2026-03-25
🧠 neurology

Brain-Only Versus GI-Only Synucleinopathy: A Comprehensive Autopsy Study With Both IHC and SAA

This comprehensive autopsy study utilizing both immunohistochemistry and RT-QuIC seed amplification assays on 50 Parkinson's disease and 128 control subjects suggests that brain-only synucleinopathy is approximately 16 times more common than GI-only synucleinopathy, while also demonstrating that the burden of alpha-synuclein in the gastrointestinal tract correlates significantly with motor and autonomic dysfunction.

Orru, C. D., Beach, T. G., Adler, C. H., Shill, H. A., Driver-Dunckley, E., Mehta, S. H., Atri, A., Lorenzini, I., Qiji (…)2026-03-24
🧠 neurology

Shifts in Clinical Practice-Changing Acute Ischemic Stroke Research Over the Last Decade

This study analyzes Acute Ischemic Stroke guidelines from 2018 and 2026 to reveal a significant paradigm shift where practice-changing research has moved away from U.S.-based and NIH-funded trials toward a landscape increasingly dominated by studies from Europe and China.

Khalid, M., Nguyen, C. H., Li, J., Bala, A., Jovin, T. G., Jadhav, A., Le, N. M., Gomez Farias, J., Kanakhara, F., Lee (…)2026-03-24
🧠 neurology

Genetic landscape of Parkinson's disease in the Personalized Parkinson Project cohort

This study characterizes the genetic landscape of 507 Dutch Parkinson's disease patients within the Personalized Parkinson Project, confirming known variant frequencies and revealing a significant interaction where a mitochondrial-function polygenic score is associated with earlier age at onset specifically in non-smokers, thereby supporting the integration of both high-impact variants and polygenic risk scores for future personalized medicine strategies.

Lüth, T., Klein, C., Helmich, R. C., Brüggemann, N., Hrir, S., Kuiperij, H. B., Gorgogietas, V., Gomes Fernandes, S. B (…)2026-03-23
🧠 neurology

A Clinical Guideline-Grounded Hybrid Agentic Framework for Holistic Epilepsy Management.

This paper proposes a clinical guideline-grounded hybrid multi-agent framework that integrates modality-specific discriminative and generative models with a central orchestrating agent to enable holistic, evidence-informed epilepsy management across six key clinical tasks, demonstrating superior performance over conventional baselines on a newly introduced multi-modal benchmark.

Pham, D. K., Giritharan, D., Oliveira, G. C. d., Vo, B. Q., Verspoor, K., Law, M., Kwan, P., Ge, Z., Mehta, D.2026-03-23