1315 papers
Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.
At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.
Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.
This study identifies the histone acetyltransferase KAT7 as a critical epigenetic regulator that drives Alzheimer's disease pathogenesis by activating Cmpk2-mediated mitochondrial DNA synthesis and subsequent neuroinflammatory signaling in microglia, establishing KAT7 inhibition as a promising therapeutic strategy to reduce amyloid burden and restore cognitive function.
By combining hierarchical drift-diffusion modelling with behavioural manipulations, this study demonstrates that semantic representations in visual working memory are more readily accessible than perceptual details, particularly when representations fall outside the focus of attention or face interference, suggesting a shift toward abstract, long-term memory-like formats under limited attentional support.
This paper introduces a conditional graph variational autoencoder framework that utilizes over 20,000 UK Biobank subjects to generate high-fidelity reconstructions of brain functional connectivity while identifying interpretable latent axes associated with biological sex and fluid intelligence.
This study demonstrates that high-level representations of a partner's actions and movement costs rapidly modulate involuntary visuomotor feedback responses within 180–230 ms, revealing that the sensorimotor system integrates social considerations into fast, reflexive motor control to facilitate seamless joint coordination.
This PRISMA-compliant systematic review and meta-analysis of 40 studies reveals that while rats exhibit robust individual-level paw preference, they lack a universal species-wide directional bias, with findings showing only modest variations across strains, test types, sex, and age.
This study establishes a novel, biofidelic goat model of traumatic optic neuropathy with optic canal fracture using transnasal endoscopy, guided by finite element analysis, to provide a clinically relevant large-animal platform for investigating TON pathophysiology and advancing translational research.
This paper presents a novel saline-free surgical protocol for creating a chronic optical window in adult Drosophila, enabling stable, longitudinal neural imaging and recording over 7–10 days.
By systematically evaluating six binding operations in recurrent spiking neural networks performing a working memory task, this study identifies that only superposition and slot-filler binding produce the factorized representational geometries observed in neural recordings, thereby establishing a taxonomy linking algebraic operations to neural signatures.
This study demonstrates that adults with dyslexia exhibit atypical neural processing of natural speech, characterized by reduced delta- and theta-band cortical decoding accuracy and cerebro-acoustic coherence, alongside increased delta-band power, particularly over the right temporal region.
This study demonstrates that applying integrated information decomposition to resting-state fMRI reveals a distinct Alzheimer's disease signature characterized by reduced global synergistic information and increased redundancy, particularly within executive and default mode networks, which correlates with cognitive decline and offers a potential biomarker for early diagnosis and stratification.