1315 papers
Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.
At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.
Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.
This study reveals that median eminence microglia rely on ApoE-dependent lipid handling to maintain myelin integrity and metabolic function, a process disrupted by Western diet and the APOE4 isoform but therapeutically restored by activating liver X receptor signaling to improve leptin responsiveness and limit weight gain.
This study reveals that the postnatal conversion of 5-methylcytosine to 5-hydroxymethylcytosine dynamically reconfigures the human neuronal epigenome throughout the first decade of life, establishing a clock-like link between DNA hydroxymethylation and transcription, chromatin state, and sex-specific gene regulation.
This study demonstrates that susceptibility to the Sound-Induced Flash Illusion increases with visual eccentricity due to higher integration weights in the periphery rather than sensory uncertainty, while spatial congruence between auditory and visual stimuli has no significant effect on this multisensory integration.
This study demonstrates that the loss of the calcium-binding protein Cbp53E in Drosophila causes delayed photoreceptor repolarization, a phenotype that can be rescued by the protein itself or its human homologs, indicating a conserved role in regulating intracellular calcium levels and sensory response dynamics.
This study demonstrates that the rat hypothalamus exhibits molecular and functional asymmetries in neurohormonal networks, enabling hemisphere-specific neural activity to be encoded into side-specific hormonal outputs that regulate peripheral processes via humoral pathways.
This study demonstrates that both deep neural network models and the human visual cortex exhibit a progressive integration of face and body representations along the visual hierarchy, where mixed-selective units emerge to support unified person perception.
Anatolution is an open-source, web-based platform that addresses the scarcity of reliable ground truth in optical microscopy by integrating stain-specific segmentation protocols with a structured multi-annotator workflow to generate consensus-validated training data for supervised cell-level morphometry.
This study reveals that nuclear tau aggregates, which form via a VCP-dependent secondary seeding event from pre-existing cytoplasmic aggregates, inhibit mRNA export and disrupt nuclear RNA biogenesis, thereby contributing to tauopathy pathology.
This protocol update provides a revised overview of the normative modelling landscape, presents an updated standardized analytical protocol for neuroimaging data that incorporates federated and longitudinal approaches, offers practical guidance with open-source code via the refactored PCNtoolkit, and releases new community models for various imaging modalities to advance individual-level analysis in computational psychiatry.
Through simulations of a biologically-grounded spiking model, this study demonstrates that dopamine-dependent plasticity in cortico-basal ganglia-thalamic circuits reshapes decision dynamics by orchestrating phase-specific subnetwork interactions that shift strategies from deliberation to committed action, thereby optimizing both speed and accuracy.