1917 papers
This study demonstrates that low-intensity focused ultrasound (LIFU) non-invasively enhances meningeal lymphatic drainage to prevent cognitive decline and reduce Alzheimer's pathology by activating the Piezo1 ion channel in lymphatic endothelial cells, offering a promising and clinically translatable therapeutic strategy.
This study characterizes YX84, a novel neuroactive steroid with a unique structure that acts as a potent GABA_A receptor full agonist and positive allosteric modulator while also inhibiting NMDA receptors, demonstrating favorable behavioral tolerability in animal models despite requiring further pharmacokinetic optimization.
This study establishes a scalable, optimized human neuron-microglia tri-culture platform using deterministically programmed cells that enables the systematic investigation of neuroimmune interactions and the modeling of genetic variants, such as the TREM2 R47H mutation associated with Alzheimer's disease, on developing neuronal network dynamics.
This paper introduces EmoFB, a biologically inspired deep neural network model that integrates intrinsic affective appraisal and external contextual steering to demonstrate how top-down feedback dynamically reshapes visual representations, improves recognition under ambiguity, and enhances alignment with human brain activity across key emotional and visual processing regions.
This study demonstrates that peripherally administered GLP-1R agonists activate the central amygdala (CeA) to induce hypophagia, a process mediated by multiple CeA neuron populations including Prkcd, Glp1r, and Sst-expressing cells, with Glp1r neurons specifically playing a crucial role in suppressing the consumption of energy-dense, palatable diets.
This study identifies somatic variants activating the RAS-MAPK pathway, particularly in *PTPN11*, as a shared developmental genetic cause of hippocampal sclerosis in drug-resistant epilepsy that lowers the threshold for seizure-induced injury, thereby redefining the condition from a purely acquired lesion to a genetic susceptibility.
This study validates the HIV-1 transgenic rat as a biological model for age-related neurocognitive impairments, demonstrating that older HIV-1 Tg rats exhibit deficits in temporal processing and attention driven by neuronal dysfunction and amyloid beta accumulation, particularly in the medial prefrontal cortex.
This study demonstrates that a combined "High-Low" training regimen of repeated normobaric hypoxia and voluntary exercise significantly improves respiratory function and reduces anxiety-like behaviors in a rodent model of chronic cervical spinal cord injury, likely mediated by beneficial shifts in peripheral T cell profiles.
The study introduces Perturb-CLEAR, a method combining pooled CRISPR screening with whole-mount imaging and transcriptomics to reveal how neurodevelopmental disorder risk genes drive gene-specific, concordant remodeling of both dendritic morphology and gene expression in the developing mouse brain.
This study reveals that in rhesus macaques, a transient burst of activity in foveal superior colliculus neurons precedes and likely facilitates the rapid representational transformation required for peripheral saccadic orienting by triggering a brief pause in target-related neurons before their motor bursts.
This paper presents a multimodal passive Brain-Computer Interface (pBCI) that fuses EEG and fNIRS data processed by a SincShallowNet deep learning model to achieve high-accuracy, objective classification of sub-clinical depressive states during an emotional working memory task.
This paper proposes that continuous temporal difference learning, which integrates fast model-based value change computations with a slower model-free cache, unifies diverse dopamine signaling patterns—including phasic errors, tonic modulation, and activity ramps—into a single computational framework validated across independent rodent datasets.
Using all-optical methods in mouse retrosplenial cortex, this study demonstrates that causal connectivity between excitatory neurons is selectively and rapidly modulated during specific phases of a decision-making task, suggesting that dynamic connectivity adjustments rather than fixed anatomy underlie distinct computational stages.
This study demonstrates that NREM sleep oscillations (slow-waves and spindles) regulate synaptic proteome remodelling to stabilize synapses, and reveals that the altered oscillation patterns in SYNGAP1-related disorders disrupt this process, leading to synaptic weakening and potential cognitive deficits.
This study demonstrates that the central nervous system flexibly combines trial-by-trial anticipation, robust control, and online adaptive feedback to optimize reaching movements, with robust strategies dominating early motion and online corrections managing later adjustments, particularly in unpredictable environments.
This study demonstrates that key molecular targets of antidepressants in the prefrontal cortex and hippocampus of adult mice exhibit significant diurnal rhythmicity, with transcript levels peaking during the active phase and specific phosphorylation events during the inactive phase, underscoring the critical importance of considering circadian timing in antidepressant research.
Using intracranial EEG recordings, this study demonstrates that progressively increasing hippocampal ripple rates and their temporal coupling with lateral temporal lobe ripples are critical mechanisms supporting human visual short-term memory of naturalistic objects.
This study establishes a scalable framework linking in vivo functional dynamics to molecular identity in the mouse hippocampus by demonstrating that heterogeneous physiological responses of CA1 interneurons during navigation align with a continuous transcriptomic axis spanning multiple GABAergic subclasses.
This study reveals that the human-specific multicopy gene FRMPD2 promotes synapse formation and cognitive function by recruiting neuroligin-1 and interacting with the F-actin network, while also influencing neuronal migration and cortical lamination during brain development.
This study demonstrates that the PET imaging probe [18F]nifene reveals significantly increased binding to α4β2* nicotinic acetylcholine receptors in the hippocampus and subiculum of postmortem Parkinson's disease brains compared to cognitively normal controls, suggesting its potential diagnostic value for detecting non-motor symptoms in Parkinson's disease.