1918 papers
This study reveals that the human-specific multicopy gene FRMPD2 promotes synapse formation and cognitive function by recruiting neuroligin-1 and interacting with the F-actin network, while also influencing neuronal migration and cortical lamination during brain development.
This study demonstrates that the PET imaging probe [18F]nifene reveals significantly increased binding to α4β2* nicotinic acetylcholine receptors in the hippocampus and subiculum of postmortem Parkinson's disease brains compared to cognitively normal controls, suggesting its potential diagnostic value for detecting non-motor symptoms in Parkinson's disease.
Using transcriptomic profiling and CRISPR/Cas9 mutagenesis in larval zebrafish, this study identifies *sim1a* as a candidate gene for strabismus that impairs eye movement via vestibulo-ocular reflex dysfunction without affecting motor neuron numbers, while establishing a pipeline for discovering genes underlying ocular motor diseases.
This study demonstrates that high-frequency optogenetic stimulation of medial prefrontal cortex (mPFC) axons, rather than local mid-striatal neurons, is the primary driver of cognitive control enhancement during ventral striatal deep brain stimulation, revealing a neuroplastic mechanism underlying the therapeutic effects of this treatment.
This study bridges animal and human research by demonstrating that placebo analgesia relies on a cortico-pontine-cerebellar system where expectation-driven predictive configurations in the cerebellum and pons correlate with pain relief.
This study demonstrates that functional MRI-based decoders can successfully translate concept representations into continuous word sequences for individuals with post-stroke aphasia, revealing that despite language deficits, the brain's underlying conceptual organization and information capacity remain largely intact.
This study reveals that glucocorticoids modulate neuronal plasticity by promoting TRKB dimerization and signaling through a physical interaction between glucocorticoid receptors and TRKB, a mechanism that operates independently of direct glucocorticoid binding to TRKB and involves the transmembrane domain.
This study presents FMN, a simulated speech dataset and explainable machine learning framework that successfully models linguistic and acoustic biomarkers to distinguish between healthy controls, mild cognitive impairment, and Alzheimer's disease with high accuracy, offering a scalable pipeline for future cognitive screening research.
This paper demonstrates that external sensory stimuli can involuntarily capture attention toward corresponding internal working memory representations, establishing a bidirectional interface between perception and memory through converging evidence from microsaccade tracking and memory performance across four experiments.
This study demonstrates that reactivating specific memories during sleep reduces neural overlap between linked items and contexts, thereby decontextualizing episodic memories to promote greater object and context specificity.
This study demonstrates that optimal anticipatory muscle inhibition during bimanual load-lifting is mediated by inhibitory beta bursts in the Supplementary Motor Area, which reduce local excitability and subsequently suppress high-gamma power to control muscle activity.
Using Adolescent Brain Cognitive Development data, this study reveals that MRI-based cognitive prediction models exhibit pervasive, modality-dependent ethnic bias that favors White participants, but demonstrates that balancing training samples and prioritizing task-based fMRI phenotypes can significantly improve fairness without sacrificing accuracy.
This study demonstrates that trial-by-trial variability in cortical oscillatory power arises from ephaptic coupling, where mesoscale electric fields and neural activity engage in circular causality to continuously shape each other and potentially drive the formation of memory ensembles.
Repeatedly inducing a hibernation-like hypometabolic and hypothermic brain state in Alzheimer's disease mice significantly slows amyloid plaque accumulation and reduces associated neuroinflammation and neurite dystrophy through global brain state modulation rather than targeting specific molecular pathways.
This study demonstrates that while pulsed transcutaneous auricular vagus nerve stimulation (taVNS) can elicit pupil dilation in intermixed experimental designs, the effect's dependence on sham location and lack of respiratory phase modulation challenge the assumption that it is mediated by the vagal afferent pathway.
This study demonstrates that while color offers no advantage for object recognition in clear images, it provides a significant benefit when spatial information is degraded by blur, suggesting that the evolutionary development of human trichromacy may have been driven by the need to compensate for optical degradation associated with aging and light exposure.
This study reveals that atypical alpha oscillatory activity in autistic children and their siblings is primarily characterized by reduced temporal stability and density of alpha bursts rather than diminished oscillatory amplitude, suggesting that the instability of these rhythms serves as a neural marker for altered cortical excitability and sensory regulation.
This study demonstrates that the cost-efficient [2,3,4,6,6-2H5]glucose produces comparable HDO levels to [2H7]glucose in both in vitro and in vivo settings, establishing it as a viable, lower-cost alternative for 2H-based metabolic imaging.
This study identifies WDR44 as a critical adaptor protein that drives the initiation of de novo α-synuclein aggregation at the lysosomal membrane in Parkinson's disease, thereby compromising lysosomal function and promoting neuronal dysfunction, which positions the WDR44–α-synuclein interaction as a promising therapeutic target for early intervention.
This study reveals that in pediatric stroke, systemic inflammation drives neutrophil infiltration through the meningeal barrier via IL-36γ signaling, establishing the meninges as a critical staging site for immune-mediated brain injury and identifying IL-36γ blockade as a promising therapeutic strategy.