1918 papers
Using high-resolution 7 Tesla MRI to overcome previous imaging limitations, this study reconstructs brainstem-augmented connectomes to demonstrate that the 58 brainstem nuclei exhibit diverse structural profiles aligned with a functional spectrum and display heterogeneous structure-function coupling that significantly influences the broader brain network.
This study reveals that SETD5 dysfunction in human astrocytes drives neuronal impairments associated with intellectual disability and autism spectrum disorder by elevating IL-6 levels through the JAK/STAT signaling pathway, a mechanism that can be partially rescued by pharmacological inhibition of JAK/STAT.
This study demonstrates that integrating human iPSC-derived microglia into midbrain organoids creates assembloids where microglia achieve a more mature, inflammation-responsive state and significantly influence the transcriptional profiles of neighboring neurons and astrocytes, offering a superior model for investigating microglia-driven neuroinflammation in Parkinson's disease.
This study introduces a novel data-driven approach to map explicitly nonlinear fMRI connectivity in human infants, revealing that these nonlinear networks uncover complementary developmental trajectories for key brain systems—such as sensorimotor and default mode networks—that remain hidden when relying solely on traditional linear methods.
This study identifies neuronal ELAVL proteins as key substrates of the CDKL5 kinase, demonstrating that CDKL5-mediated phosphorylation of these proteins enhances their mRNA binding and protein synthesis capabilities, which are essential for neuronal viability and the proper formation of cortical circuits in the visual cortex.
This ABCD study of over 10,000 children reveals that early sustained bilingual exposure positively influences reading development by enhancing anterior corpus callosum connectivity, a neuroanatomical pathway distinct from the brain size-mediated mechanism through which genetic risk for dyslexia operates.
This study demonstrates that the basal ganglia progressively transform high-dimensional, feature-selective visual representations in the striatum into low-dimensional signals of behavioral relevance in the GPe and SNr, where trained responses distinguish between "Go" and "No-Go" cues rather than specific visual features.
This study demonstrates that structural white-matter connectivity mediates age-related declines in visual perceptual representations while simultaneously supporting the enhanced semantic representations observed in the aging brain.
This paper presents an iterative approach for automatically optimizing the delay search range in breath-hold fMRI, which significantly improves the accuracy and reliability of cerebrovascular reactivity mapping in clinical populations such as stroke survivors and patients with Moyamoya disease.
This study utilizes a naturalistic approach-avoidance task in mice to demonstrate that frontal cortex norepinephrine, dopamine, and serotonin exhibit distinct and synergistic dynamics in encoding innate fear and reward, providing new insights into the neurochemical mechanisms underlying motivated behavior and emotional disorders.
While Tbx1 heterozygosity specifically within the oligodendrocyte lineage induces a selective shift toward smaller myelinated axons in the mouse fimbria and a transient cognitive enhancement, it fails to recapitulate the broader myelination defects and behavioral impairments seen in constitutive mutants, indicating that Tbx1's role in non-oligodendrocyte cells is critical for the full neurodevelopmental phenotype.
This study demonstrates that in Alzheimer's disease, alpha-synuclein co-pathology selectively amplifies the association between amyloid and tau accumulation across all Braak stages without altering the downstream relationship between tau pathology and cognitive decline.
This study provides convergent multimodal evidence from resting-state fMRI and EEG that psychosis is characterized by a shift toward cortical hyperexcitability, evidenced by reduced Hurst exponents and aperiodic spectral exponents that align with specific molecular pathways involving GABA, potassium channels, and various neurotransmitter receptors.
The study identifies the long noncoding RNA Dory as a critical regulator of female-specific spatial learning and memory in mice, demonstrated by the impairment of this function in Dory-null females but not males, alongside sex-specific alterations in hippocampal gene and protein expression.
This study demonstrates that combining functional near-infrared spectroscopy (fNIRS) with electrodermal activity (EDA) significantly improves subject-independent classification of arousal and valence, achieving the highest performance among tested multimodal configurations.
Using a comprehensive multimodal imaging approach, this study found no evidence for magnetite-based magnetoreceptors in the mole-rat eye, suggesting that if these animals possess a magnetic sense, it likely resides outside the eye or operates via a different mechanism.
This study establishes Hierarchical Phase-Contrast Tomography (HiP-CT) as a non-destructive, label-free reference modality that bridges the microstructural gap in human connectomics by validating its ability to resolve complex, micrometer-scale white matter fiber architectures that complement and exceed the resolution of diffusion MRI.
This study demonstrates that a novel selonsertib-eluting polymer coating on cochlear implant electrodes effectively mitigates acute tissue damage by inhibiting apoptosis and inflammation while promoting cell survival, thereby establishing a proof of concept for targeted drug delivery to improve device performance and longevity.
This paper introduces bi-cross-validation as a principled, data-driven framework for evaluating and selecting dynamic functional connectivity models in fMRI, demonstrating its ability to avoid circularity, balance model complexity with goodness-of-fit, and effectively compare static versus dynamic approaches across varying spatial dimensionalities.