1541 papers
Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.
At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.
Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.
Using large-scale spatial transcriptomics, this study maps the brain-wide architecture of diurnal transcription in mice and reveals that region-specific rhythmic disruption occurs early in Alzheimer's disease pathogenesis, preceding substantial amyloid plaque deposition.
By combining MEG and pupillometry in older adults, this study demonstrates that individual differences in top-down attention arise from heterogeneous neural network configurations shaped by sensory processing and strategic resource allocation, highlighting the necessity of moving beyond group averages to understand attentional control.
This paper presents a perforated microfluidic microtunnel device that enables large-scale, guided formation of unidirectional neuronal networks from human stem cells, significantly enhancing electrophysiological recording quality and facilitating computer-aided design of future neural architectures.
This paper introduces an open-source, isotropic 7.72 {micro}m/voxel post-mortem human brain dataset acquired via Hierarchical Phase-Contrast Tomography at the ESRF, which bridges the resolution gap between MRI and histology to enable detailed 3D visualization and quantitative analysis of complex neuroanatomy.
This study demonstrates that constitutively active subthreshold Ih and Kir currents jointly regulate the passive properties, intrinsic excitability, and EPSP-spike coupling of medial prefrontal cortex Layer 1 VIP interneurons, thereby shaping their ability to filter signals and modulate information flow within the cortical column.
This study demonstrates that a missense mutation in *Kalrn* causes adolescent-onset dendritic regression specifically in supragranular layers of the visual cortex, leading to impaired mismatch negativity and reduced functional connectivity, thereby linking cytoskeletal alterations to psychiatric-relevant sensory integration deficits.
This study identifies a spatially confined rostral hotspot within the medial nucleus accumbens shell, enriched with Stard5-expressing D1-SPNs, as a critical and specific regulator of hedonic feeding that operates independently of metabolic need or aversive responses.
This study demonstrates that while the Visual Word Form Area (VWFA) exhibits consistent, task-agnostic localization and text-selectivity within individual brains across both children and adults, significant inter-individual variability in the precise arrangement of category-selective regions obscures these responses when data are averaged in template space.
This study demonstrates that even among neurons of the same cell type with identical branching patterns, fine morphological details and the spatial distribution of ion channels interact to generate significant response variability, challenging the notion that total membrane area and input resistance alone determine neuronal function.
This manuscript, which originally investigated behavioral unresponsiveness and impaired auditory event-related potentials in the anterior insula during rat absence seizures, has been withdrawn from bioRxiv because the corresponding author could not access the original data required to finalize the study.