1943 papers
This study demonstrates that applying segment-wise along-tract 3D tractometry to diffusion MRI reveals focal, reproducible white matter microstructural alterations in specific hippocampal and commissural pathways associated with stimulant misuse, offering superior anatomical specificity compared to traditional whole-bundle analyses.
In the largest structural connectivity study of bipolar disorder to date, researchers analyzed 449 patients and 510 controls across 16 sites to reveal widespread disruptions in emotion- and reward-related brain networks that are significantly influenced by illness severity, duration, and medication use.
This paper introduces "channel capacity," a model-based measure of directed information transfer combined with a sliding-window framework, and validates its ability to sensitively detect task-related changes, specifically avoid false positives, and capture meaningful temporal variability in dynamic brain connectivity across human and rodent multimodal neuroimaging datasets.
This magnetoencephalography study reveals that viewing the "Inscapes" animation and eyes-open rest produce distinct aperiodic neural activity profiles, particularly showing widespread differences in frontoparietal and occipital regions with a specific reversal in the primary visual cortex, indicating that these two conditions are not interchangeable for analyzing broadband spectral dynamics or excitation/inhibition balance.
This study demonstrates that in poison frog tadpoles, dietary quality—not quantity—programs the development of specific brain circuits and anorexigenic neurons to shape social feeding behaviors, while food quantity primarily drives somatic growth.
This study demonstrates that the antipsychotic drug clozapine suppresses psychosis-like behaviors in mice by reducing anti-NMDAR autoantibody levels and subsequent microglial phagocytosis, thereby revealing a novel immunomodulatory mechanism of action for antipsychotic drugs.
This study demonstrates that the hyaluronan-modifying enzyme Hapln1 promotes spinal cord regeneration in adult zebrafish by enhancing progenitor cell proliferation through hyaluronan-CD44b signaling, highlighting a pro-regenerative role for specific extracellular matrix components in scarless repair.
This study demonstrates that Sphingosine-1-Phosphate Receptor 1 (S1PR1), regulated by JAK-STAT3 signaling, is essential for driving competition-dependent astrocyte morphogenesis and non-overlapping tiling in the developing murine cortex.
By applying unsupervised autoencoders to high-dimensional neural recordings from the songbird nucleus HVC, this study reveals that complex rhythmic vocal behaviors are governed by a low-dimensional three-dimensional neural dynamic that precisely mirrors syllabic repetition rates and respiratory motor patterns.
By constructing functional brain networks based on correlations between multiscale entropy profiles rather than direct temporal synchrony, this study demonstrates that such an approach reveals stronger modular organization and significantly greater sensitivity to biologically meaningful variability, such as robust sex differences, compared to conventional methods.
By pairing the ultra-dense, naturalistic audiovisual recordings from the First 1,000 Days dataset with cognitively grounded learning agents, this study demonstrates that everyday environments provide sufficient structure for children to acquire speech units and vocabulary through incremental learning and daily rehearsal, thereby establishing a unified mechanistic framework for understanding individual language development trajectories.
This study demonstrates that AAV-delivered, mutant allele-specific RNA interference effectively prevents and reverses myofibrillar myopathy in a mouse model by restoring the disrupted LDB3-PKC-FLNc mechanosensing pathway and normalizing associated protein aggregates and signaling networks.
This study challenges the dominant linear rate code model by demonstrating that the human orbitofrontal and ventromedial prefrontal cortices utilize a non-linear probabilistic population code to represent both subjective value and its uncertainty, a mechanism that directly predicts behavioral choice stability and confidence.
While children with developmental language disorder (DLD) achieve comparable behavioral learning from pseudoword repetition as typically developing peers, fMRI reveals that their underlying neural mechanisms are less efficient, characterized by reduced left-hemisphere specialization in the inferior frontal gyrus and weaker suppression of the default mode network.
By applying multidimensional diffusion-relaxation MRI to map voxel-wise microstructural phenotypes across the adult lifespan, this study reveals that normative human brain aging is characterized by a progressive, non-uniform reorganization at the cellular level, marked by increasing heterogeneity, a loss of microscopic restriction, and the expansion of extracellular space.
This study utilizes a large cohort of healthy adults and comprehensive source-reconstructed MEG analysis, while controlling for key confounding factors, to characterize healthy ageing as a frequency-specific shift in oscillatory power and increased coherence, alongside declining frontal network dynamics that appear to play a compensatory role in maintaining cognitive performance.
This study optimizes and applies molecularly-guided single-cell spatial proteomics to the mammalian brain, successfully characterizing region-specific neuronal proteomes, non-neuronal responses to injury, and disease-specific disruptions in dopaminergic neurons associated with Parkinson's disease.
This study demonstrates that cross-region co-occurring ripple oscillations facilitate long-distance neuronal co-firing that scales with memory load and reinstates stimulus-specific patterns, thereby supporting distributed working memory representations in the human brain.
This study demonstrates that aged AppNL-G-F mice, a model of early-onset Alzheimer's disease, exhibit a progressive phenotype of hyperactivity, fragmented sleep with long wake bouts, and reduced NREM/REM sleep—particularly in females—suggesting that amyloid-beta deposition impairs state transition mechanisms and validating this strain for investigating early-stage interventions.
This study systematically evaluates the transduction efficiency and toxicity of 18 AAV serotypes across three distinct human iPSC-derived neuronal subtypes and cerebellar organoids, identifying AAV6, AAV6.2, and AAV2.7m8 as robust vectors while establishing a critical benchmark for optimizing gene delivery in human neural models.