1935 papers
This study demonstrates that N3 and REM sleep enhance the translation of neural responses (specifically the late positive potential) into accurate emotional memory, while revealing that PTSD is associated with diminished neural differentiation between negative and neutral stimuli and that women exhibit poorer memory for negative stimuli compared to men.
This paper presents a fully automated, cloud-scalable, and open-source pipeline that utilizes machine learning and rule-based algorithms to standardize, correct structural anomalies, and accurately relabel dendritic trees in large-scale 3D neural reconstructions, thereby enhancing the accuracy, efficiency, and reproducibility of neuroanatomical data quality control.
This study demonstrates that while individual auditory response properties cannot reliably distinguish between the central nucleus and cortex of the inferior colliculus in mice, a random forest classifier combining multiple frequency response area features can robustly identify these subdivisions across both awake and anesthetized states.
This study utilizes in vivo two-photon calcium imaging and graph-theoretical analysis to reveal that the functional topology of the mouse primary motor cortex exhibits distinct, state-dependent organizational patterns, characterized by larger connectivity during motion and stronger modular segregation with small-world properties under anesthesia.
This study demonstrates that a single-dose, rAAV-mediated prostaglandin gene therapy effectively lowers intraocular pressure and preserves both optic nerve anatomy and function in a mouse model of end-stage glaucoma, offering a potential long-acting alternative to current compliance-limited eye drop treatments.
This study demonstrates that Syngap1 haploinsufficiency disrupts the coordinated relative maturation of neuronal populations across cortical areas, leading to a dissociation between sensory hypofunction and movement-linked hyperfunction that characterizes distributed network imbalances in neurodevelopmental disorders.
This study demonstrates that hippocampal sharp wave-ripples organized into clusters (cSPW-Rs) serve as a fundamental syntactic unit for memory consolidation by enhancing hippocampal-neocortical dialogue, facilitating network segregation, and enabling the concatenation of extended spatial sequences during sleep.
This paper proposes a theoretical framework demonstrating that local dendritic excitatory-inhibitory balance and branch-specific inhibition enable biophysical spiking circuits to store and selectively recall overlapping associative memories by creating binary-like states, enlarging attraction basins, and autonomously gating access to distinct memory sets.
This study demonstrates that lactation drives increased food-seeking and hedonic feeding in mice by enhancing mesolimbic dopamine signaling from the ventral tegmental area to the nucleus accumbens, a mechanism that is essential for supporting the elevated energy demands of milk production.
This study reveals that auricular vagus nerve stimulation alleviates temporomandibular disorder pain in mice by activating a specific subset of vagal dopaminergic afferents that suppress trigeminal nociceptor sensitization, establishing a peripheral interoceptive pathway for targeted chronic pain modulation.
By combining functional PET imaging with Granger causality analysis in 86 healthy adults, this study reveals that the human brain operates through directed metabolic circuits where the efficiency of glucose utilization and the strength of temporally ordered connections significantly predict cognitive and affective functions, challenging the notion that higher metabolism always yields better performance.
This study introduces AMAge-Net, an attention-guided multimodal deep learning framework that effectively integrates structural and functional MRI data to achieve state-of-the-art accuracy and interpretability in predicting brain age and characterizing lifespan neurodevelopmental trajectories.
This study demonstrates that applying segment-wise along-tract 3D tractometry to diffusion MRI reveals focal, reproducible white matter microstructural alterations in specific hippocampal and commissural pathways associated with stimulant misuse, offering superior anatomical specificity compared to traditional whole-bundle analyses.
In the largest structural connectivity study of bipolar disorder to date, researchers analyzed 449 patients and 510 controls across 16 sites to reveal widespread disruptions in emotion- and reward-related brain networks that are significantly influenced by illness severity, duration, and medication use.
This paper introduces "channel capacity," a model-based measure of directed information transfer combined with a sliding-window framework, and validates its ability to sensitively detect task-related changes, specifically avoid false positives, and capture meaningful temporal variability in dynamic brain connectivity across human and rodent multimodal neuroimaging datasets.
This magnetoencephalography study reveals that viewing the "Inscapes" animation and eyes-open rest produce distinct aperiodic neural activity profiles, particularly showing widespread differences in frontoparietal and occipital regions with a specific reversal in the primary visual cortex, indicating that these two conditions are not interchangeable for analyzing broadband spectral dynamics or excitation/inhibition balance.
This study demonstrates that in poison frog tadpoles, dietary quality—not quantity—programs the development of specific brain circuits and anorexigenic neurons to shape social feeding behaviors, while food quantity primarily drives somatic growth.
This study demonstrates that the antipsychotic drug clozapine suppresses psychosis-like behaviors in mice by reducing anti-NMDAR autoantibody levels and subsequent microglial phagocytosis, thereby revealing a novel immunomodulatory mechanism of action for antipsychotic drugs.
This study demonstrates that the hyaluronan-modifying enzyme Hapln1 promotes spinal cord regeneration in adult zebrafish by enhancing progenitor cell proliferation through hyaluronan-CD44b signaling, highlighting a pro-regenerative role for specific extracellular matrix components in scarless repair.
This study demonstrates that Sphingosine-1-Phosphate Receptor 1 (S1PR1), regulated by JAK-STAT3 signaling, is essential for driving competition-dependent astrocyte morphogenesis and non-overlapping tiling in the developing murine cortex.