1935 papers
By constructing a large-scale microscale directed functional circuit map from calcium imaging of over 57,000 neurons, this study reveals how brain state modulates the multi-scale organization of visual cortex circuitry, identifying specific dominant pathways, laminar dynamics, and structure-function coupling patterns across arousal levels.
Using a large-scale fMRI study of 772 participants, this paper identifies a distinct "extended language network" comprising 17 language-selective brain areas outside the canonical fronto-temporal system, demonstrating that while language processing is more widespread than previously thought, it remains highly localized to a small fraction of the brain's grey matter.
By combining layer-specific fMRI and EEG recordings with deep neural network modeling, this study reveals that human visual object perception involves early feedforward signals encoding medium-to-high complexity features in the middle layers of visual cortex, followed by later feedback signals in superficial layers that refine representations to high complexity.
Using intracranial recordings from participants watching a multilingual movie, this study reveals that the frontal cortex dynamically organizes audiovisual processing through a flexible ventral-auditory and dorsal-visual gradient that adapts to changing movie contexts to construct a coherent percept.
Using dual-meter stimuli to isolate attentional effects, this EEG study demonstrates that individual differences in neural entrainment to attended metrical structures predict the magnitude of the anticipatory P300 response to metrical violations, suggesting a direct link between bottom-up entrainment and top-down anticipation in musical meter perception.
This study reveals that the transmembrane protein Flower orchestrates astrocyte fitness in neurodegeneration through a bifurcated mechanism where its N-terminal domain drives extracellular vesicle-mediated elimination of less-fit neighbors, while its C-terminal "win" isoform ensures cell-intrinsic survival and neuroprotection under stress.
This study reveals that while Median Preoptic Nucleus astrocytes exert sex-dependent effects on sleep regulation and homeostatic pressure, they do not mediate the sleep-suppressive actions of estrogen, thereby identifying a novel sex-based divergence in astrocytic sleep control that operates independently of estrogenic modulation.
This study demonstrates that early cerebral small vessel disease is characterized by distinct disruptions in neurovisceral integration and emotional processing across neural, physiological, and behavioral levels, independent of traditional cardiovascular risk factors and cognitive decline.
This study demonstrates that movement and decision vigor are governed by separate, independent time-cost signals rather than a single global utility, with their apparent coordination arising only when both processes are influenced by a shared temporal history.
This study demonstrates that placental Insulin-like Growth Factor 1 (IGF1) insufficiency in mice drives sex-specific neurodevelopmental deficits, causing male offspring to exhibit reduced forebrain growth and autism-relevant behavioral abnormalities, while female offspring show distinct molecular alterations and opposing behavioral phenotypes, highlighting the critical role of placental IGF1 in preventing neurodevelopmental disorders.
This study demonstrates that acute hypoxia triggers distinct, temporally dissociated network-level BOLD dynamics, where functional connectivity increases monotonically while local neural activity (ALFF) undergoes nonlinear, network-specific modulation, supporting a framework of cerebral oxygen budgeting that reshapes functional dynamics rather than uniformly suppressing them.
This preregistered fMRI study reveals that while striatal sensitivity to shared rewards typically predicts brain responses to reciprocated trust, this relationship is significantly altered by depressive symptoms and social closeness, with depression reversing the expected neural patterns in close relationships.
This study provides the first direct evidence in humans that sleep-specific hippocampal ripples drive the selective reactivation of single neurons encoding successfully remembered items, thereby establishing a cellular mechanism for human memory consolidation.
This study demonstrates that across multiple Drosophila species, olfactory behaviors are driven by a selective preference for the most statistically distinctive and ecologically informative volatile components within complex natural host odour blends.
By analyzing longitudinal multimodal data, this study reveals that while individual stroke patients' functional connectome fingerprints stabilize within three weeks, they undergo prolonged system-specific reorganization that ultimately drives recovery, with these early functional signatures serving as predictive biomarkers for long-term cognitive impairment.
This study presents openly available, high-resolution voxelwise normative models of brain morphometry derived from over 58,000 scans to capture individual heterogeneity across the lifespan, demonstrating their utility in identifying replicable, personalized brain alterations in both preterm birth and rare genetic neurodegenerative disorders.
This study identifies the auditory nerve glial transition zone (GTZ) as a critical and previously overlooked site of age-related immune-glial dysfunction, characterized by unique macrophage-mediated myelin debris accumulation and neuroinflammation that contributes significantly to age-related hearing loss.
This study identifies a specific, small subset of Calbindin1-positive dopamine neurons in the substantia nigra as essential for the motor expression, but not the timekeeping, of food anticipatory activity in mice, revealing a genetic dissociation between circadian prediction and behavioral output.
This study demonstrates that a single dose of the antipsychotic drug clozapine induces long-lasting behavioral and cortical activity changes in mice lasting up to nine days, mediated by specific layer 5 neurons, suggesting that antipsychotic dosing intervals could be extended beyond current clinical practices.
By analyzing longitudinal histopathology data in a mouse model of Parkinson's disease, this study reveals that -synuclein propagation follows rise-and-fall trajectories rather than simple accumulation, identifying a low-dimensional vulnerability axis where regions with stronger decline dynamics possess higher monoaminergic composition and proteostatic gene expression.