1930 papers
By combining large-scale motor unit recordings with a novel simulation-based inference framework, this study successfully quantifies previously inaccessible patterns of homonymous and heteronymous recurrent inhibition across multiple human muscles, revealing distinct muscle- and intensity-dependent modulation during voluntary contractions.
This study provides causal evidence that theta-band temporal interference stimulation targeting the dorsal anterior cingulate cortex enhances the neural gain of prediction error encoding during reward feedback in humans, as demonstrated by increased feedback-related negativity and altered prediction error slopes.
This study reveals that the dorsolateral prefrontal cortex in individuals with Tourette disorder exhibits pervasive transcriptional remodeling across neuronal and glial populations, characterized by upregulated biosynthetic programs and stress-associated activation, particularly in oligodendrocytes and neurons.
This study reveals that while the *Calca* gene-derived CGRP is expressed in trigeminal and geniculate neurons, its alternative transcript preprocalcitonin is uniquely found in murine type II taste cells, suggesting a novel reciprocal regulatory mechanism involving CGRP1R-expressing progenitor and stromal cells that may influence taste signaling and regeneration.
Using whole-brain fMRI in behaving mice combined with reinforcement learning modeling, this study reveals that the periaqueductal gray (PAG) is selectively recruited during reversal learning to suppress previously rewarded actions and update behavior, highlighting a novel role for this midbrain structure in cognitive flexibility beyond its traditional association with threat processing.
This study demonstrates that the auxiliary subunit LRRC55 is selectively enriched in cerebellar Purkinje cells, where it is essential for modulating BK channel activity to regulate neuronal firing, synaptic plasticity, and normal motor coordination.
This study demonstrates that kainate receptors are critical determinants in the epileptic dentate gyrus, where their slow excitatory signaling synergizes with sodium currents to lower the threshold for seizure initiation, sustain pathological activity, and drive a transition from organized to highly disordered network dynamics.
This study demonstrates that effective treatment for GLUT1 deficiency syndrome requires dual AAV-mediated restoration of GLUT1 in both astrocytes and endothelial cells, establishing a new therapeutic framework based on a novel astrocyte-targeting vector and a specific regulatory element.
This study demonstrates that a structurally constrained, jointly tuned Kuramoto phase-oscillator model successfully reproduces key functional connectivity features and network properties in the swine brain, while revealing modest longitudinal changes in structure-function coupling following traumatic brain injury.
This study demonstrates that the posteroventral medial amygdala (MeApv) is essential for suppressing male odor preference in female mice during nursing, as lesions to this region prevent the loss of such preference despite increased neural activity in the accessory olfactory system.
This study reports the development of novel AAV variants via a proprietary capsid engineering platform that, in non-human primates, achieve unprecedented pan-CNS transduction with significantly higher brain expression and a markedly improved safety profile compared to AAV9.
Using pupillometry across three experiments, this study reveals that while overt speech consistently triggers pupil dilation, inner speech exhibits a dissociable, load-dependent arousal profile characterized by constriction or minimal dilation, indicating that covert verbal production operates at a reduced and flexibly scaled arousal cost compared to overt speech despite shared cortical substrates.
This study reveals that in live *C. elegans*, the nanoscale mobility and organization of voltage-gated calcium channels at active zones are actively controlled by pools of readily releasable synaptic vesicles through distinct mechanisms involving SNARE assembly and specific regulatory proteins, thereby ensuring precise neurotransmission.
This paper demonstrates the benefits of adopting the general-purpose MMPose library for animal pose estimation by benchmarking various models across different experimental scenarios, revealing a critical trade-off between accuracy and speed while highlighting the limitations of current foundation models in zero-shot generalization.
This study challenges the prevailing reliance on dense pose estimation for animal behavior analysis by demonstrating that whole-body segmentation combined with temporal feature engineering achieves comparable accuracy to complex keypoint tracking, suggesting that researchers should prioritize behavioral dataset volume and temporal dynamics over anatomical detail to optimize cost and performance.
By constructing a large-scale microscale directed functional circuit map from calcium imaging of over 57,000 neurons, this study reveals how brain state modulates the multi-scale organization of visual cortex circuitry, identifying specific dominant pathways, laminar dynamics, and structure-function coupling patterns across arousal levels.
Using a large-scale fMRI study of 772 participants, this paper identifies a distinct "extended language network" comprising 17 language-selective brain areas outside the canonical fronto-temporal system, demonstrating that while language processing is more widespread than previously thought, it remains highly localized to a small fraction of the brain's grey matter.
By combining layer-specific fMRI and EEG recordings with deep neural network modeling, this study reveals that human visual object perception involves early feedforward signals encoding medium-to-high complexity features in the middle layers of visual cortex, followed by later feedback signals in superficial layers that refine representations to high complexity.
Using intracranial recordings from participants watching a multilingual movie, this study reveals that the frontal cortex dynamically organizes audiovisual processing through a flexible ventral-auditory and dorsal-visual gradient that adapts to changing movie contexts to construct a coherent percept.
Using dual-meter stimuli to isolate attentional effects, this EEG study demonstrates that individual differences in neural entrainment to attended metrical structures predict the magnitude of the anticipatory P300 response to metrical violations, suggesting a direct link between bottom-up entrainment and top-down anticipation in musical meter perception.