1919 papers
This study demonstrates that inhibitory rTMS targeting the right dorsolateral prefrontal cortex selectively enhances unsupervised statistical learning by shifting cognitive processing toward a more exploratory information-sampling strategy, rather than by suppressing episodic memory systems.
This study demonstrates that transient amygdala beta bursts, rather than sustained oscillations, serve as a precise temporal mechanism for modulating hippocampal neuronal dynamics during emotional processing, specifically suppressing hippocampal firing during high-arousal negative events to facilitate emotional appraisal.
This study demonstrates that maternally administered LSD rapidly crosses into the embryonic cerebrospinal fluid within minutes, acutely activates the choroid plexus, and leads to lasting alterations in cortical development and adult offspring behavior in mice.
By performing cellular-resolution calcium imaging across five regions of mouse sensorimotor cortex during a reach-to-grasp task, the study reveals that while neuronal response properties shift abruptly at anatomical borders, behaviorally relevant activity is organized into distinct, intermingled subpopulations that span multiple areas rather than being strictly segregated by cortical region.
By combining high-density electrophysiology, a taste decision-making task, and recurrent neural network modeling in the mouse gustatory cortex, this study demonstrates that distinct subpopulations of neurons encoding stimuli linearly and choices categorically are essential for driving population dynamics and successful behavioral performance, whereas other activity patterns are dispensable.
This fMRI study demonstrates that the human brain encodes the direction of naturalistic, repetitive actions through distributed representations spanning early sensory, parietal, and motor regions within the action observation network, extending beyond simple motion processing to support complex action understanding.
This study demonstrates that in elderly individuals, particularly those with constrained ventilation, elevated cardiac sympathetic activity during orthostatic stress correlates with exaggerated cerebral blood flow velocity changes, revealing a distinct maladaptive cardiac-cerebrovascular crosstalk that may compromise perfusion in ageing and post-stroke conditions.
This study demonstrates that transiently inhibiting oxytocin-expressing neurons during specific developmental windows, particularly infancy and the juvenile period, induces long-term, sex-dependent alterations in social behavior and body composition in mice, while also revealing a critical role for these neurons around birth in regulating parturition and neonatal feeding.
This study demonstrates that age-dependent disruption of the MICOS complex in vulnerable brain regions leads to mitochondrial structural deficits, impaired bioenergetics, and reduced neuronal excitability, establishing a mechanistic link between MICOS dysfunction and early Alzheimer's disease pathology.
By combining large-scale motor unit recordings with a novel simulation-based inference framework, this study successfully quantifies previously inaccessible patterns of homonymous and heteronymous recurrent inhibition across multiple human muscles, revealing distinct muscle- and intensity-dependent modulation during voluntary contractions.
This study provides causal evidence that theta-band temporal interference stimulation targeting the dorsal anterior cingulate cortex enhances the neural gain of prediction error encoding during reward feedback in humans, as demonstrated by increased feedback-related negativity and altered prediction error slopes.
This study reveals that the dorsolateral prefrontal cortex in individuals with Tourette disorder exhibits pervasive transcriptional remodeling across neuronal and glial populations, characterized by upregulated biosynthetic programs and stress-associated activation, particularly in oligodendrocytes and neurons.
This study reveals that while the *Calca* gene-derived CGRP is expressed in trigeminal and geniculate neurons, its alternative transcript preprocalcitonin is uniquely found in murine type II taste cells, suggesting a novel reciprocal regulatory mechanism involving CGRP1R-expressing progenitor and stromal cells that may influence taste signaling and regeneration.
Using whole-brain fMRI in behaving mice combined with reinforcement learning modeling, this study reveals that the periaqueductal gray (PAG) is selectively recruited during reversal learning to suppress previously rewarded actions and update behavior, highlighting a novel role for this midbrain structure in cognitive flexibility beyond its traditional association with threat processing.
This study demonstrates that the auxiliary subunit LRRC55 is selectively enriched in cerebellar Purkinje cells, where it is essential for modulating BK channel activity to regulate neuronal firing, synaptic plasticity, and normal motor coordination.
This study demonstrates that kainate receptors are critical determinants in the epileptic dentate gyrus, where their slow excitatory signaling synergizes with sodium currents to lower the threshold for seizure initiation, sustain pathological activity, and drive a transition from organized to highly disordered network dynamics.
This study demonstrates that effective treatment for GLUT1 deficiency syndrome requires dual AAV-mediated restoration of GLUT1 in both astrocytes and endothelial cells, establishing a new therapeutic framework based on a novel astrocyte-targeting vector and a specific regulatory element.
This study demonstrates that a structurally constrained, jointly tuned Kuramoto phase-oscillator model successfully reproduces key functional connectivity features and network properties in the swine brain, while revealing modest longitudinal changes in structure-function coupling following traumatic brain injury.
This study demonstrates that the posteroventral medial amygdala (MeApv) is essential for suppressing male odor preference in female mice during nursing, as lesions to this region prevent the loss of such preference despite increased neural activity in the accessory olfactory system.
This study reports the development of novel AAV variants via a proprietary capsid engineering platform that, in non-human primates, achieve unprecedented pan-CNS transduction with significantly higher brain expression and a markedly improved safety profile compared to AAV9.