1918 papers
Using light sheet microscopy to track pan-neuronal activity in *C. elegans*, this study reveals that isoflurane induction causes a gradual, highly variable increase in neuronal disconnection and disorganization, representing a rapid, individualized reversal of the emergence process.
This study demonstrates that intranasal administration of IL-17A rescues motor deficits and restores Purkinje neuron function in a mouse model of Spinocerebellar Ataxia Type 2 by normalizing excessive inhibitory synaptic input, highlighting IL-17A signaling as a promising therapeutic target for the disease.
Environmental enrichment enhances hippocampal sparse coding and memory performance by potentiating somatostatin-mediated feedback inhibition, which increases the diversity and selectivity of CA1 pyramidal cell activity.
This study demonstrates that unawareness of tool-action errors (anosognosia of apraxia) in left-hemisphere stroke survivors arises from degraded action knowledge, which impairs error detection and subsequently reduces the likelihood of attempting to correct those errors.
This paper introduces NeuraGEM, a neural architecture that combines fast transient activity with slow synaptic plasticity to implement online latent state discovery, thereby explaining how neural circuits detect context changes and support adaptive behavior through mechanisms like curriculum-dependent learning and line-attractor dynamics.
This study demonstrates that while reverberation and interruptions impair syllable recall in spatial selective attention tasks, pupil dilation dynamics are driven primarily by the perceptual salience of stimuli rather than by task performance or environmental expectations.
This study utilizes LC-MS/MS to reveal a conserved yet sex-specific remodeling of the tRNA epitranscriptome in Alzheimer's disease across cellular, animal, and human postmortem models, leading to the development of a novel tRNA-based modification score that links RNA metabolism dysregulation to disease severity and offers a potential avenue for early biomarkers.
This study reveals that early-life adversity induces enduring, sex-specific disruptions in adult reward behaviors by altering corticotropin-releasing hormone receptor type 1 (CRHR1) expression in paraventricular thalamic neurons, and demonstrates that deleting this receptor in those specific cells can rescue such behavioral deficits.
By analyzing three *C. elegans* datasets, this study demonstrates that mitotic lineage provides significant predictive power for neural connections beyond what is explained by cell type alone, suggesting that developmental family trees are a crucial factor in connectome assembly.
This paper presents a scalable, modular computational pipeline that leverages machine learning-based segmentation to automate the tracing and assembly of axons across large-scale serial sections, enabling mesoscale connectomics studies of the whole human brain.
This study presents an optimized, low-toxicity retrograde monosynaptic tracing method using EnvA-pseudotyped rabies viruses in larval zebrafish that enables efficient, cell-type-specific mapping of neural circuits, as demonstrated by revealing the ipsilateral preference and subtype specificity of cerebellar granule cell-to-Purkinje cell connections.
This paper proposes a framework that synthesizes speech from ECoG signals recorded during imagined speech by using overt speech audio as a surrogate ground truth to train a Transformer-based decoder and a pre-trained vocoder, achieving high correlation with target audio across 13 participants.
This study utilizes BioID proximity proteomics combined with evolutionary and structural bioinformatics to map a co-evolved LRRK2 regulatory network linked to centrosomes and microtubules, revealing how the protein's interactions with specific cellular sub-compartments are dynamically modulated by its kinase activity and upstream effectors.
This paper presents a hybrid micro-ECoG array that combines silicone elastomers and polyimide films to enable high-density, multi-scale brain activity recording, functional mapping across species, targeted depth electrode insertion, and local optogenetic stimulation for investigating cortico-cortical interactions.
This study demonstrates that the fruit fly's central complex integrates visual and mechanosensory cues of self-motion through specific neuronal populations to computationally infer ambient wind direction, enabling effective upwind navigation despite the inability to directly measure external forces.
This study demonstrates that dopamine neuron-specific loss of Synaptojanin 1 causes severe synaptic degeneration and dopamine deficiency, which triggers a unique compensatory emergence of striatal tyrosine hydroxylase-positive interneurons (iTHINs) that partially restore function, highlighting both the critical role of SJ1 in synaptic maintenance and a novel adaptive plasticity mechanism in Parkinson's disease.
This study reveals that cholinergic neurons in the human brain mount a presynaptic plasticity response to tau pathology, characterized by increased VAChT levels, which serves as a critical mechanism for cognitive resilience in presymptomatic Alzheimer's disease.
This study demonstrates that parieto-occipital alpha and frontocentral theta oscillations dynamically track escalating within-trial risk and contextual uncertainty during reward anticipation in sequential decision making, revealing distinct neural mechanisms for reduced deliberation, heightened attention, and action commitment.
This study reveals that microglial TREM2 plays a dual role in spinal cord injury by promoting the clearance of degenerating motoneurons while simultaneously facilitating the regeneration of others, with these effects varying by activation profile and sex.
This study demonstrates that inhibitory rTMS targeting the right dorsolateral prefrontal cortex selectively enhances unsupervised statistical learning by shifting cognitive processing toward a more exploratory information-sampling strategy, rather than by suppressing episodic memory systems.