Distilling the neurophenomenological signatures of pure awareness during Transcendental Meditation

By combining EEG with Temporal Experience Tracing in experienced Transcendental Meditation practitioners, this study identifies distinct, distributed multivariate neural patterns—specifically involving temporal entropy, aperiodic dynamics, and low-frequency connectivity—that systematically characterize the neurophenomenological signatures of pure awareness.

Chandia-Jorquera, A., van Mil, S. D., Estarellas, M. + 3 more2026-04-02🧠 neuroscience

When the psychedelic state's over: limited evidence for persistent neurophysiological changes in naturalistic psychedelic users

This study found that long-term naturalistic psychedelic users, after a period of abstinence, showed largely non-significant differences in resting-state EEG oscillatory power, signal complexity, and network connectivity compared to matched non-users, suggesting that the neurophysiological signatures observed in acute administration studies may not persist as stable traits in chronic users.

Wojcik, M., Orłowski, P., Adamczyk, S. + 4 more2026-04-02🧠 neuroscience

Aerobic exercise prevents the loss of endogenous pain modulation in male and female rats with traumatic brain injury.

This study demonstrates that while traumatic brain injury combined with tibia fracture causes chronic hindlimb hyperalgesia and disrupts endogenous pain modulation in rats, voluntary aerobic exercise initiated shortly after injury effectively restores normal pain sensitivity and descending pain control in both sexes for up to 180 days, offering a non-pharmacological alternative to sex-specific serotonergic or noradrenergic drug interventions.

Irvine, K.-A., Ferguson, A. R., Clark, D. J.2026-04-02🧠 neuroscience

Gray matter Volume Modulates the Effect of Acute Physical Activity on Reading Comprehension and Cognitive Load in Adolescents. The Cogni-Action Project

This study demonstrates that in adolescents, gray matter volume in key brain regions modulates the cognitive benefits of acute physical activity, with cooperative high-intensity interval training (C-HIIT) proving superior to moderate continuous training and sedentary behavior in reducing cognitive load and improving reading comprehension through specific brain-volume interactions.

Martinez-Flores, R., Super, H., Sanchez-Martinez, J. + 7 more2026-04-02🧠 neuroscience

Decomposing representational drift across wake and sleep

By tracking representational drift in the mouse olfactory cortex across wake and sleep cycles, this study reveals that sleep initiates a distinct reorganization of odor representations through decorrelation and rotation, rather than simply continuing online learning, and provides the first evidence for temporally compressed olfactory replay associated with piriform cortex sharp waves.

Harris, J. J., Schaefer, A. T., Kollo, M.2026-04-02🧠 neuroscience

Perineuronal nets reflect a continuum of fast-spiking specialization in adult parvalbumin interneurons

By integrating Xenium spatial transcriptomics with PNN-labeling in adult mouse cortex, this study reveals that perineuronal nets enwrap the vast majority of parvalbumin interneurons and mark a transcriptional continuum of fast-spiking specialization, distinguishing mature PNN-positive cells from more plastic PNN-negative counterparts.

Groedem, S., Vatne, G. H., Lensjoe, K. K. + 4 more2026-04-02🧠 neuroscience

Distributed representational encoding of food attributes in ventral visual cortex

Using fMRI and representational similarity analysis, this study demonstrates that the ventral visual cortex encodes food attributes through a functional dissociation where the lateral occipitotemporal cortex represents both visual and subjective properties, while the fusiform gyrus selectively encodes perceived caloric content beyond visual similarity.

Marrazzo, G., Pimpini, L., Kochs, S. + 3 more2026-04-02🧠 neuroscience

Transcranial Magnetic Stimulation in Awake Rhesus macaques: Validation of a Novel Non-invasive Apparatus

This study presents and validates a novel non-invasive head- and arm-fixation apparatus that enables the successful application of human-standard Transcranial Magnetic Stimulation protocols, including adaptive motor threshold determination and short-interval intracortical inhibition measurement, in awake rhesus macaques without surgical intervention.

Padanyi, A., Knakker, B., Kiefer, E. + 2 more2026-04-02🧠 neuroscience

Encoder-based Curvature-Aware Regularization for estimating asymmetric fiber orientation distribution functions in diffusion MRI

This paper proposes EnCAR, a self-supervised Transformer-based method that incorporates curvature-aware regularization to improve the estimation of asymmetric fiber orientation distribution functions (A-FODs) in complex white matter regions, outperforming existing methods in capturing intricate fiber geometries while maintaining accuracy in symmetric areas.

Taherkhani, M., Pizzolato, M., Morup, M. + 1 more2026-04-02🧠 neuroscience