1519 papers
Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.
At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.
Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.
This study demonstrates that macroscopic and radiological indicators of brain perfusion quality can be misleading, as they may appear adequate even when the addition of hyperosmotic dehydrating agents to the perfusant causes severe ultrastructural damage that compromises the preservation of neural circuitry.
This study demonstrates that a computational model using Dynamical Graph Grammar, driven by a single Teneurin-m morphogen gradient combined with resource constraints and self-avoidance rules, successfully replicates the complex asymmetric branching patterns and statistical features of biological ddaE neuron dendrites in Drosophila larvae.
This study demonstrates that rats achieve few-shot learning by rapidly remapping abstract "role" representations in the orbitofrontal cortex onto specific actions, enabling them to generalize task structures and adapt to new contingencies within just a few trials.
This study reveals that theft recidivists with kleptomania exhibit heightened loss aversion and price sensitivity linked to imbalanced prefrontal cortex activity, challenging the conventional view of theft as purely reward-seeking behavior by suggesting that an abnormally inflated fear of monetary loss drives recurrent stealing.
This study demonstrates that the C. elegans kinase KIN-29 promotes stress-induced sleep by regulating mitochondrial reactive oxygen species signaling, which acts downstream of KIN-29 and upstream of the sleep-inducing ALA neuron to link metabolic stress with sleep regulation.
Using two-photon calcium imaging in 5xFAD mice, this study demonstrates that amyloid pathology compresses the dynamic range of hippocampal CA1 neurons, degrades spatial coding, and impairs memory-related learning, with these deficits intensifying near plaques and with age.
This study reveals that childhood deprivation is linked to sex-specific alterations in frontostriatal connectivity and subsequent anhedonia in young adulthood, with males showing a distinct vulnerability characterized by positive connectivity associations and increased anhedonia risk compared to females.
This study demonstrates that colon-to-hind paw cross-organ sensitization is partially mediated by spinal astrocyte TrkB.T1, which drives neuroinflammation and TNF-α release to activate lumbar DRG neurons via distinct PI3K/Akt and p-CREB pathways, thereby upregulating Piezo2 and CGRP to induce mechanical hypersensitivity while leaving thermal hyperalgesia unaffected.
This study demonstrates that metabotropic glutamate receptors dynamically regulate trans-thalamic communication by enhancing feedforward sensory propagation in cortical neurons and shifting thalamic firing modes to prioritize novel stimuli, thereby adaptively controlling cortical decision-making.
Using 7T fMRI data and language-aligned models, this study demonstrates that the high-level visual cortex is sensitive to the compositional structure of natural scenes rather than just object co-occurrence, suggesting that language supervision can help artificial vision models develop similar structured representations.