1918 papers
This study identifies a top-down neural circuit projecting from the dorsal subiculum to the mammillary body that acts as a bistable switch to gate the duration of feeding bouts, thereby regulating the fragmentation of ingestive behavior independent of homeostatic state.
This study demonstrates that cervical repetitive magnetic stimulation significantly enhances respiratory recovery after spinal cord injury in mice by promoting diaphragmatic motor output, reducing neuroinflammation and scarring, and modulating the extracellular environment to support neuronal plasticity.
This study demonstrates that midazolam suppresses glioma progression both in vitro and in vivo by attenuating neuronal activity, which subsequently downregulates neuron-derived IGF1 signaling and inhibits the PI3K/AKT pathway to reduce tumor growth.
This paper introduces a rapid, minimally invasive EEG recording method for mice using thin needle electrodes that eliminates the need for skull drilling or screw placement, achieving stable, high-quality data in under 15 minutes while improving animal welfare.
By analyzing a nanoscale connectome of the mouse visual cortex, researchers discovered that axonal groups forming functional ensembles repeatedly cluster their synapses onto specific dendritic branches of multiple pyramidal cells in consistent spatial patterns, revealing that coordinated neuronal activity leaves characteristic anatomical signatures in cortical microarchitecture.
This study utilizes a novel EEG analysis approach to reveal that while episodic memory and word retrieval involve distinct oscillatory patterns in left frontal and temporal regions, they share similar alpha-band activity in right parietal regions, suggesting a homologous function for these areas in processing less-specific representations.
This study identifies ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injury that originate from acid sphingomyelinase-expressing ependymal cilia, cross the blood-brain barrier, and induce neuronal mitochondrial dysfunction and apoptosis, thereby serving as potential therapeutic targets.
This study identifies cerebellar inhibitory neurons as the specific origin of life-threatening dystonic crises and demonstrates that modulating their activity or stimulating their thalamic projections can both induce and alleviate these episodes, offering a promising therapeutic target.
This study demonstrates that individual differences in internal models of typical scenes predict unique gaze exploration patterns, but only when strategic, expectation-guided viewing is encouraged rather than during free viewing.
This study provides empirical evidence supporting Integrated Information Theory by demonstrating that integrated information ({Phi}) within local neuronal circuits significantly decreases during NREM sleep, particularly during off-periods, independent of firing rates or cortical structure, thereby linking the collapse of {Phi} to the loss of consciousness.
By combining CRISPR-mediated tagging, proteomics, and cryo-EM, researchers directly visualized diverse endogenous mGluR2 assemblies in mouse brain tissue, revealing distinct active and inactive states and ternary complexes that differ significantly from previously studied recombinant systems.
This study reveals that distinct mutations in the SPT enzyme subunits drive divergent sphingolipid metabolic shifts—characterized by enhanced canonical flux in ALS, altered 1-deoxysphingolipid production in HSAN1, and a mixed profile in sensory-motor neuropathies—which underlie their contrasting clinical phenotypes and necessitate tailored therapeutic strategies, such as avoiding L-serine supplementation in ALS despite its potential benefit for HSAN1.
This paper proposes and validates a compartment-specific spike-timing dependent plasticity (STDP) model, grounded in experimental calcium signaling data, which explains how reduced depression in complex distal dendritic branches leads to the enrichment of retinotopically displaced inputs in visual cortex neurons.
By generating high-resolution cross-species 3D atlases of marmoset, macaque, and human cerebella, this study reveals that the cerebellar cortex expands disproportionately more than the deep cerebellar nuclei across primates, establishing nonuniform scaling as a key organizational principle that reshapes the cerebellum's role in distributed brain networks.
By recording single-unit activity in the prefrontal cortex of monkeys performing spatial and object working memory tasks, this study demonstrates that rule learning induces both task-specific and generalized neural plasticity, characterized by changes in firing rates, decoding accuracy, unexplained variance, and population trajectory separation that correlate with behavioral improvements across different contexts.
This study reveals that chronic stress-induced hyperactivity of POMC neurons is driven by reduced inhibitory input from DMH GABAergic neurons rather than local AgRP neurons, and that chemogenetic activation of these DMH neurons can attenuate this hyperactivity in both sexes.
Using an isogenic iPSC model, this study reveals that the YWHAG R132C mutation causes cytoskeletal instability and a decoupling of calcium homeostasis from signaling in cortical neurons, characterized by elevated baseline calcium and reduced network activity that are partially modifiable by ROCK pathway inhibition and lovastatin treatment.
Ribosome profiling of parvalbumin interneurons reveals that while adult-enhanced plasticity shares some synaptic and extracellular matrix gene expression with juvenile critical periods, it relies on distinct molecular pathways—such as mechano-transduction in adults versus DNA repair and heterochromatin regulation in juveniles—indicating that adult plasticity does not simply recapitulate developmental mechanisms.
This study reveals that the somatic slow afterhyperpolarization in hippocampal pyramidal cells is generated by highly organized CaRyK protein complexes distributed as functional ion channel nodes across a spectrin-actin polygonal lattice, which is essential for controlling spike output patterns.
This study demonstrates that in rats, cervical epidural stimulation efficacy for recruiting forelimb muscles is maximized by placing large electrodes directly over the C6 dorsal root entry zone with a wide interelectrode distance and a distant return, while current orientation and high-definition montages showed no benefit or reduced efficacy.