1918 papers
This study reveals that CDKL5 phosphorylates nELAVL proteins to regulate the size and inter-condensate communication of their biomolecular assemblies, thereby stabilizing activity-dependent mRNAs like *Fos* and ensuring the experience-dependent maturation of the visual cortex, a mechanism disrupted in CDKL5 deficiency disorder.
Using dynamic clamp, this study reveals that nociceptor excitability follows non-linear biophysical rules where partial, simultaneous inhibition of Nav1.7 and Nav1.8 channels causes a supralinear collapse of action potentials in specific neuronal subtypes, offering a mechanistic blueprint for effective, subtype-selective pain therapy.
This study demonstrates that the astrocyte-specific circadian clock regulates the daily remodeling of perineuronal nets, thereby controlling synaptic plasticity and learning behaviors.
This study demonstrates that increasing cognitive demands in mice drive a spatially organized recruitment of mature granule cells in the dentate gyrus's suprapyramidal blade for pattern separation, while adult-born granule cells play a critical modulatory role in maintaining circuit dynamics and task performance under high-load conditions.
This paper proposes an energy-efficient neural network model that integrates cognitive maps, stochastic computing, and compositional coding to enable goal-directed imagination and planning for novel problems using only local synaptic plasticity, offering a viable alternative to resource-intensive deep learning for edge devices.
This study successfully developed and validated a comprehensive questionnaire in Indonesia to assess microplastic exposure, knowledge, and attitudes in relation to cognitive function, demonstrating its effectiveness as a tool for evaluating MP-related cognitive risks among Indonesian adults.
This study demonstrates that the presence of the Neo cassette in the Mirc13tm1Mtm/Mmjax mouse line alters neighboring gene expression, thereby establishing the necessity of a specific two-step breeding protocol to properly generate and validate functional miR-141/200c conditional knockout mice.
This study demonstrates that while LIS1 depletion in astrocytes is non-lethal, its loss in projection neurons of adult mice triggers rapid lethality and widespread axonal degeneration, suggesting that LIS1 is essential for maintaining axon integrity through its regulation of cytoplasmic dynein 1.
This study demonstrates that semantic relationships in the human brain are encoded through consistent geometric vector directions and parallelogram structures within neural manifolds, mirroring the principles found in large language models and supporting energy-efficient neural coding theories.
This study demonstrates that while visuomotor feedback responses track the temporal pattern of visual errors, the motor learning system selectively extracts the amplitude of the feedback response during the holding period to update future motor commands, rather than transferring the error's temporal pattern to subsequent trials.
This paper introduces a cost-efficient, mesh-based computational pipeline that accurately classifies postsynaptic targets across millions of synapses in large-scale electron microscopy volumes, enabling a comprehensive census of the mouse visual cortex that reveals both expected and novel connectivity patterns while generalizing effectively to other connectomes.
Focal application of nicotine to layer 4C of macaque V1 induces widespread, heterogeneous gain changes that propagate through the cortical circuit to bias perceived contrast in an orientation-dependent manner, demonstrating that precise modulation at the thalamocortical gate fundamentally reshapes both population coding and perception.
This paper presents a novel adaptive mesh refinement strategy for the charge-based boundary element method accelerated by the fast multipole method, which utilizes a new residual-driven error estimator to achieve high-resolution, numerically stable forward modeling for transcranial electrical stimulation and EEG across realistic multi-tissue head models.
This study presents a novel histological and imaging pipeline that reveals the previously uncharacterized three-dimensional organization of individual axons in post-mortem human white matter, uncovering striking regional diversity in architectural motifs that likely reflect local adaptations to spatial and connectivity constraints.
This study demonstrates that glutamatergic synapses between neurons and oligodendrocyte precursor cells in the mouse corpus callosum undergo a developmental switch from short-term depression to facilitation, driven by synchronized glutamate release and coordinated pre- and postsynaptic maturation mechanisms similar to those in grey matter.
This study utilizing simultaneous hippocampal and scalp EEG recordings in two chronic nicotine users suggests that depressive status modulates neural responses to acute nicotine, with depressed individuals showing attenuated reward-related oscillatory activity while both groups exhibit reduced alpha hippocampal-cortical connectivity indicative of a shift toward relief processing.
This study demonstrates that latent brain state dynamics derived from fMRI data serve as sensitive neural markers that predict early amyloid-beta accumulation and cognitive impairment in older adults, outperforming direct amyloid levels in identifying individuals at risk for future cognitive decline.
By combining patterned optogenetic stimulation with calcium imaging in immature ferret visual cortex, this study demonstrates that millimeter-scale cortical networks selectively amplify inputs aligned with endogenous recurrent subnetworks, thereby leveraging intrinsic dynamics to stabilize and refine sensory representations during development.
This study utilizes paired transcriptomic and epigenomic data from post-mortem human brain tissue to reveal that transcriptional and chromatin alterations in Brodmann Area 22, particularly within glutamatergic L4/5 intratelencephalic neurons and RFX3-dependent networks, are most pronounced in individuals with autism and a known genetic diagnosis, thereby linking regulatory architecture to verbal communication deficits.
This paper presents the first extensive, high-resolution (400 μm) reconstruction of human subcortical fiber pathways using ultra-high-resolution ex vivo dMRI to create a validated atlas that guides neuromodulation therapies and paves the way for future in vivo clinical applications.