1918 papers
This longitudinal study of 1,112 adolescents reveals that distinct brain maturation patterns in cortical and subcortical regions mediate the influence of various exposome domains, particularly family environment, on the development of general cognitive ability.
The paper introduces MAPseq2, a user-friendly protocol that significantly enhances the sensitivity and cost-effectiveness of barcoded connectomics methods like MAPseq, BARseq, BRICseq, and ConnectID by achieving up to a ten-fold improvement in both metrics.
This study demonstrates that some head-fixed mice employ an active sensing strategy by wiggling a control wheel at specific frequencies to enhance visual stimulus salience and improve decision-making accuracy during low-contrast trials, independent of arousal states.
This study identifies unstable spike initiation driven by sodium-channel variability as a conserved electrophysiological phenotype across diverse neurological disease models, linking subtle microscale biophysical instabilities to macroscale circuit dysfunction and demonstrating that antiepileptic drugs can restore stability.
This study demonstrates that a network growth model governed by distance-dependent activity correlations and competition on folded cortical surfaces can spontaneously generate the stereotyped, mirror-reversed retinotopic maps of the primate extrastriate visual cortex without predefined boundaries or layouts, suggesting that geometric constraints fundamentally shape higher-order map organization.
This study demonstrates that early blood-based 1H NMR metabolomics, integrated with machine learning, can accurately diagnose neonatal hypoxic-ischemic encephalopathy within one hour of birth by identifying a distinct metabolic signature characterized by elevated lactate, glutamate, and pyroglutamate alongside depleted glucose and glutamine.
This study demonstrates that Parkin is essential for neuronal maturation and survival, and shows that small-molecule agonists like FB231 can activate Parkin to protect dopaminergic neurons and mitigate alpha-synuclein pathology in Parkinson's disease models.
This study integrates single-neuron 3D reconstructions with the mouse Hippocampus Gene Expression Atlas to classify 689 subiculum projection neurons into 12 distinct cell types, revealing their spatial organization, unique connectivity motifs, and specific roles in brain-wide networks regulating diverse behaviors.
This study found that while voluntary facial sensorimotor representations are generally similar between individuals with Tourette Syndrome and typically developing controls, the TS group exhibited reduced sensorimotor activation overlap and a lack of shared supplementary motor area engagement across movements, suggesting altered motor integration or action initiation.
By developing a multiscale digital brain co-simulator that integrates a spiking olivo-cerebellar network with a mouse virtual brain, researchers demonstrated that cerebellar spike processing is essential for generating gamma-band coherence between motor and sensory cortices, thereby revealing the cellular mechanisms underlying the cerebellum's role in sensorimotor prediction.
This study demonstrates that incorporating white matter microstructure metrics into whole-brain neural mass models significantly improves the prediction of schizophrenia diagnosis and reveals personalized excitation-inhibition imbalances, offering a promising avenue for understanding the disorder's mechanisms and guiding personalized treatment.
This study demonstrates that in the lateral habenula, Synaptotagmin-2 and Synaptotagmin-3 act as distinct calcium sensors that differentially regulate glutamate and GABA release, respectively, from dual-transmitter terminals originating in the globus pallidus internus, thereby establishing a presynaptic molecular mechanism for controlling excitatory-inhibitory balance.
This study demonstrates that coordinated peripheral immune signaling changes emerge during the preclinical stage of Alzheimer's disease, preceding key biomarkers like tau elevation and blood-brain barrier disruption, and are driven by circulating factors specific to AD pathology.
This study reveals that in monkey somatosensory cortex, motor corollary discharge and proprioceptive feedback signals occupy orthogonal population subspaces, a geometric arrangement that enables flexible integration for accurate body state estimation during voluntary movement and the detection of external perturbations.
This study demonstrates that deleting the TNFR1 receptor specifically in astrocytes of aged Alzheimer's disease mice rapidly restores memory by rebalancing hippocampal circuit excitability through synaptic pathway modulation in neurons, a therapeutic effect that occurs even in late-stage disease without altering amyloid load or astrogliosis.
Using data from the ABCD Study, this research reveals that the association between BMI and subcortical brain microstructure in adolescents is nonlinear, characterized by a modest positive relationship across most of the BMI distribution that accelerates markedly above the 80th percentile.
This study demonstrates that children's superior offline consolidation of motor sequences compared to adults is supported by the greater persistence of task-related hippocampal activity patterns during post-learning wakefulness.
This study integrates single-nuclei transcriptomic data from the prefrontal cortex across APOE genotypes to reveal that APOE4/4 status drives distinct cellular vulnerabilities in Alzheimer's disease, specifically characterized by the selective depletion of NFT-signature excitatory neurons and dose-dependent alterations in microglial subpopulations, including the upregulation of the risk gene FRMD4A.
By integrating resting-state MEG data from 350 adults with multimodal cortical maps, this study demonstrates that specific anatomical and molecular markers, including cytoarchitecture, gene expression, and neurotransmitter receptors, predict regional neurophysiological dynamics and reveal how age-related changes in neural activity align with neuroinflammation, signaling systems, and vascular organization across the human lifespan.
Using MEG and a dynamic informational connectivity approach, this study demonstrates that temporal attention selects stimuli from competing streams by dynamically routing information through occipito-fronto-cingulate and occipito-temporal pathways via transient bursts and theta-rhythmic replay, highlighting that the timing of neural communication is critical for stimulus selection.