1968 papers
This study demonstrates that aged AppNL-G-F mice, a model of early-onset Alzheimer's disease, exhibit a progressive phenotype of hyperactivity, fragmented sleep with long wake bouts, and reduced NREM/REM sleep—particularly in females—suggesting that amyloid-beta deposition impairs state transition mechanisms and validating this strain for investigating early-stage interventions.
This study systematically evaluates the transduction efficiency and toxicity of 18 AAV serotypes across three distinct human iPSC-derived neuronal subtypes and cerebellar organoids, identifying AAV6, AAV6.2, and AAV2.7m8 as robust vectors while establishing a critical benchmark for optimizing gene delivery in human neural models.
This paper introduces and validates a real-time closed-loop TMS-EEG system that directly detects oscillatory phase without prediction, demonstrating superior triggering probability and phase precision compared to traditional prediction-based methods for targeting both spontaneous and event-related brain oscillations during active cognition.
This study reveals that retinogeniculate synapses exhibit an inverse correlation between synaptic strength and short-term plasticity, where weak synapses facilitate and strong synapses depress, suggesting that the relative contribution of these inputs to relay neuron firing is activity-dependent.
This study reveals that while people with Parkinson's disease exhibit an increased perception of effort, their sensitivity to reward remains intact, suggesting that altered effort perception rather than reward processing is a key driver of bradykinesia.
This study presents an electrodiffusive computational framework demonstrating that ionic ephaptic effects primarily increase neuronal population firing rates, whereas electric ephaptic effects drive subtle spike timing shifts that lead to a stable, unique phase preference among neurons.
This study demonstrates that repeated fentanyl administration in male Wistar rats induces antinociceptive tolerance and duration-dependent alterations in perineuronal net and parvalbumin expression within the orbitofrontal cortex, suggesting these structural changes mediate opioid-induced behavioral effects.
This study demonstrates that adolescent Wistar rats exposed to dry-hit nicotine e-cigarette vapor exhibit distinct behavioral responses, including increased open-arm exploration in the elevated plus maze, and show significantly elevated perineuronal net expression specifically in the central nucleus of the amygdala compared to those exposed to saturated vapor.
This study demonstrates that phosphorylation of the S655 residue on the Alzheimer's Amyloid Precursor Protein (APP) alters its interactome by recruiting specific partners like FUBP3 and Tubulin, thereby promoting neuronal differentiation and the formation of longer neuritic extensions.
By integrating heart rate variability with demographic, anthropometric, and cardiovascular data in a high-southern-latitude cohort of older adults, this study demonstrates that autonomic regulation is best characterized as a multidimensional physiological continuum rather than by isolated descriptors, revealing six distinct autonomic phenotypes with significant implications for risk stratification.
This paper establishes an analytical and empirical link between Granger Causality and Effective Connectivity in fMRI by deriving a quadratic relationship between them, demonstrating that their convergence requires large datasets and offering methodological guidance for reconstructing directed brain networks.
This study reveals that in the visual cortex of humans and macaques, broadband signals primarily provide synergistic information for early nonlinear pattern recognition, whereas narrowband gamma oscillations offer redundant information to facilitate sustained information maintenance.
This study utilizes population-level analysis of dendritic spine nanostructure in mouse models to distinguish schizophrenia from autism spectrum disorder phenotypes and identifies the gene Ecrg4 as a critical molecular driver of the impaired spine dynamics characteristic of schizophrenia.
This study demonstrates that color-enhancing notch filters, such as Enchroma SuperX glasses, improve visual search performance for normal trichromats in naturalistic tasks by increasing color salience along specific axes like magenta-green, though the efficacy depends on the spectral characteristics of the background environment.
This study demonstrates that BDNF signaling from axon terminals to the nucleus relies on local, mTOR-dependent translation of Rab5 within axons to sustain the retrograde transport of signaling endosomes necessary for neuronal plasticity.
This study demonstrates that self-initiated action timing in mice is governed by a brain-wide, trial- and time-dependent deterministic drive that synergizes with within-trial noise, revealing a distributed rather than hierarchical mechanism for decision-making.
Although electrophysiological recordings and modeling demonstrate that primate foveal cones effectively backpropagate signals from their terminals to their outer segments without requiring voltage-gated amplification, these signals are unlikely to influence phototransduction, suggesting that visual encoding in these cells remains compartmentalized.
Using fMRI during a multi-step saccadic maze task, this study demonstrates that while macaques possess a distributed brain network corresponding to the human multiple-demand system for cognitive control, there are notable species differences in the specific organization and extent of lateral frontal cortex activation.
This study demonstrates that retinal microglia are essential mediators of NGF-dependent neuroprotection, as their depletion significantly impairs NGF/TrkA signaling and leads to the loss of retinal ganglion cells.
This study demonstrates that the RNA editing enzyme ADARB1 is a robust, species-conserved nuclear marker for spiral ganglion neurons, enabling reliable automated cell counting as a time-efficient alternative to manual methods for assessing auditory neuron degeneration.