1825 papers
This study reveals that mouse cerebrospinal fluid-contacting neurons utilize a novel, cilia-independent mechanosensory mechanism where drebrin-stabilized, F-actin-enriched filopodia detect mechanical stimuli via PKD2L1 channels, representing an evolutionary divergence from the ciliary-based sensing found in aquatic vertebrates.
This study employs multivariate information theory to reveal that the human brain's structural connectome imposes distinct constraints on higher-order functional interactions, where redundant information sharing occurs in densely connected, locally clustered regions, while synergistic sharing relies on globally central nodes with high betweenness centrality.
This study demonstrates that rapid, localized glutamate uptake by both glial and neuronal transporters is essential for T-stellate cells in the ventral cochlear nucleus to linearly encode sound intensity and maintain excitability, a critical function that distinguishes them from other auditory neurons like bushy cells which are less dependent on this mechanism.
The authors present Connectome-based Spatial Statistics (CBSS), a scalable framework that overcomes alignment and computational challenges to enable systematic, large-scale population analyses of white-matter microstructure across diverse cohorts, establishing a common reference for diffusion MRI studies.
This study presents a multi-omic atlas of the African turquoise killifish brain revealing that aging is characterized by microglial expansion and conserved glucocorticoid signaling activation, which can be mitigated by pharmacological inhibition to rescue key aging phenotypes.
This study demonstrates that sparse granule cell activation serves as a unifying principle for stable and accurate cerebellar learning, where feedback inhibition drives temporal sparsity for trace learning while both inhibition pathways support pattern identification, with spatial sparsity being critical for preventing memory interference in incremental learning.
This study demonstrates that machine learning analysis of 40-Hz EEG phase-locking features can identify a distinct Phelan-McDermid syndrome-like electrophysiological subtype within idiopathic autism, supporting the use of biomarker-guided stratification for more precise ASD characterization.
This pilot study found that combining gesture observation and neuromodulation of the left posterior middle temporal gyrus did not enhance verb retrieval in chronic aphasia beyond the effects of either intervention alone, as the two methods appeared to attenuate each other's benefits.
This study uses Event-Related Potentials (ERPs) to demonstrate that, despite theoretical distinctions between Tense and Agreement in Arabic, both types of violations elicit similar biphasic N400-P600 brain responses in neurotypical individuals, suggesting they rely on the same underlying cognitive processing mechanisms.
This study utilizes mass spectrometry to map stage-dependent tau post-translational modifications across multiple brain regions in Alzheimer's disease, revealing that specific early phosphorylation events precede aggregation-associated ubiquitination while identifying modifications that may play protective roles.
Using magnetoencephalography, this study demonstrates that the cerebellum generates temporal predictions for somatosensory omissions via right lobule VI beta-band activity, which follows a logistic decay pattern with a critical threshold between 2 and 4 seconds, thereby defining the duration limits of the cerebellum's internal clock.
This study demonstrates that oculomotor metrics, specifically cognitive vergence and pupil differentiation during an oddball task, are significantly associated with cerebrospinal fluid tau and amyloid biomarkers in mild cognitive impairment patients, suggesting these non-invasive measures can serve as accessible functional indicators of Alzheimer's disease network dysfunction.
By integrating multi-omics and electrophysiological analyses of patient-derived dopaminergic neurons, this study reveals that rare genetic variants in Parkinson's disease converge to disrupt mitochondrial function and lipid homeostasis, leading to impaired neuronal excitability and identifying specific protein-lipid pathways as potential therapeutic targets.
This study characterizes the distinct electrophysiological properties of mesodiencephalic junction neurons projecting to the inferior olive, revealing that they are spontaneously active, capable of high-frequency bursting and rebound firing, and able to integrate neocortical and cerebellar inputs to support cerebellar learning.
This study demonstrates that recurrent neural networks trained to classify sequences by their latent algebraic patterns spontaneously develop low-rank recurrent connectivity, which creates a structured population state space enabling the formation of abstract, identity-independent relational representations that support rapid generalization.
This study reveals that mouse locus coeruleus norepinephrine neurons are topographically organized by morphology, gene expression, and axonal projections, with distinct dorsal and ventral subpopulations encoding specific learning signals such as choice changes, reward prediction errors, and reward-related attention to support flexible behavior.
This study demonstrates that sex-specific synaptic plasticity mechanisms in the infralimbic cortex, including the necessity of amygdala-projecting neuron activity and GRIN2B-dependent structural remodeling for fear extinction, challenge the assumption of uniform neural processing between males and females and highlight the limitations of one-size-fits-all therapeutic approaches for memory-related disorders.
This study maps the molecular dynamics of learning in the mouse striatum by profiling transcriptomes across 396 biopsies from 66 mice, revealing that strong, widespread transcriptional changes occur primarily during early learning and providing an interactive web tool to explore these gene expression patterns.
This study utilizes single-cell transcriptomics and proteomics of projection neurons within the hippocampal-prefrontal circuit to reveal schizophrenia-associated molecular alterations, including region-specific phosphorylation changes, co-expression networks, and disrupted directional connectivity driven by glial interactions and inhibitory neuropeptide downregulation.
This paper proposes an alternative hypothesis for Alzheimer's disease suggesting that A{beta} plaques and tau tangles are not merely toxic waste but represent hypertrophic pathologies of a functional tanycyte-derived canal system where these proteins normally serve structural and regulatory roles in brain waste removal.