🧠 Category

neuroscience

1523 papers

Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.

At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.

Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.

🧠 neuroscience

VISUAL EXPERIENCE SHAPES ARM POSITION SENSE IN INTERNAL AND EXTERNAL REFERENCE FRAMES AND ASSOCIATED CORTICAL LOAD

This study demonstrates that lifelong visual impairment impairs arm position sense and increases cortical cognitive load, particularly when representing limb position in external coordinates, suggesting that visual experience optimizes proprioceptive processing and that the brain preferentially relies on internal joint-based representations when task kinematics allow.

Oh, K., Natraj, N., Wheaton, L. A., Prilutsky, B. I.2026-06-11
🧠 neuroscience

Multiple coexisting pathways to synchronization shape seizure dynamics in a mesoscale mouse brain model

This study utilizes a mesoscale mouse brain network model to demonstrate that epileptic seizure synchronization emerges through multiple competing dynamical pathways rather than a single dominant route, revealing how distinct mesoscale sub-networks and node ablation selectively shape seizure propagation and suggesting new strategies for targeted intervention.

Kumar, N., Gandhi, S. R.2026-06-11
🧠 neuroscience

Mutant SOD1 expressed by oligodendrocytes aggregates in myelinic nanochannels and accelerates disease progression in familial ALS mice

This study demonstrates that mutant SOD1 expressed by oligodendrocytes aggregates within myelinic nanochannels, and that preserving the integrity of these channels is critical for slowing disease progression in familial ALS mouse models.

Mot, A. I., Li, Y., Dibaj, P., Tzvetanova, I. D., Gerwig, U. C., Bogale, T. A., Goebbels, S., Möbius, W., Bergles, D. E (…)2026-06-11
🧠 neuroscience

Top-down attention modulates auditory sustained responses but not the neural processing advantage for vowels

Using MEG, this study demonstrates that while top-down attention modulates sustained auditory responses and accelerates periodicity processing in non-vocal sounds, it does not diminish the intrinsically enhanced neural processing advantage characteristic of vowels.

Orekhova, E. V., Fadeev, K. A., Morozova, M. V., Romero Reyes, I. V., Plieva, A. M., Stroganova, T. A.2026-06-11
🧠 neuroscience

Tuft dendrite spikes are accompanied by selective input from distinct functional networks

Simultaneous imaging in mice performing a cued task reveals that tuft dendritic spikes in layer 5 premotor neurons are driven by highly specific, multiphasic synaptic inputs from both strongly population-coupled subnetworks encoding task transitions and sparsely coupled subnetworks encoding task outcomes, suggesting these spikes integrate distinct functional networks to coordinate context-specific engagement.

Gable, J., Newman, Z. L., Young, S., Scheib, J., Bliese, S., Miller, N., Kerlin, A.2026-06-11
🧠 neuroscience

Functional ultrasound imaging reveals pathway-specific visual system reorganization in young Cln3-/- mice

Using functional ultrasound imaging, this study reveals that young Cln3-/- mice exhibit early, pathway-specific reorganization of central visual processing characterized by enhanced extrageniculate activation and reduced geniculostriate activity, which correlates with regional pathological burden despite the absence of severe retinal degeneration.

Yin, F., Ding, Y., Chang, H. E., Prifti, V., Feng, J., Freedman, E. G., Foxe, J. J., Doyley, M. M., Wang, K. H.2026-06-10
🧠 neuroscience

Pathology in resected areas of FDG PET hypometabolism in pediatric epilepsy patients with focal cortical dysplasia

This study demonstrates that in pediatric patients with focal cortical dysplasia, FDG-PET hypometabolic borders contain pathological cells (specifically dysmorphic neurons) alongside the core lesion, supporting the inclusion of these surrounding areas in surgical resections to achieve high seizure-freedom rates.

Lam, J., von Ellenrieder, N., Hamel, M., Ruan, Y., Dufresne, D., Guiot, M.-C., Karamchandani, J., Bernhardt, B., Dudley (…)2026-06-10