1296 papers
Neuroscience explores the intricate machinery of the brain and nervous system, seeking to understand how we think, feel, and move. From the microscopic dance of individual neurons to the complex networks that shape our memories and behaviors, this field peels back the layers of our biological selves to reveal the origins of consciousness and disease.
At Gist.Science, we bring these discoveries directly from bioRxiv, the leading preprint server for biological sciences, to a broader audience. We process every new neuroscience preprint as it is uploaded, transforming dense academic manuscripts into clear, plain-language explanations alongside detailed technical summaries. This ensures that both curious readers and specialists can stay current with the latest breakthroughs before they are formally published.
Below are the latest neuroscience papers we have processed from bioRxiv, offering fresh insights into the workings of the mind.
This study identifies neuronal ELAVL proteins as key substrates of the CDKL5 kinase, demonstrating that CDKL5-mediated phosphorylation of these proteins enhances their mRNA binding and protein synthesis capabilities, which are essential for neuronal viability and the proper formation of cortical circuits in the visual cortex.
This ABCD study of over 10,000 children reveals that early sustained bilingual exposure positively influences reading development by enhancing anterior corpus callosum connectivity, a neuroanatomical pathway distinct from the brain size-mediated mechanism through which genetic risk for dyslexia operates.
This study demonstrates that the basal ganglia progressively transform high-dimensional, feature-selective visual representations in the striatum into low-dimensional signals of behavioral relevance in the GPe and SNr, where trained responses distinguish between "Go" and "No-Go" cues rather than specific visual features.
This study demonstrates that in Alzheimer's disease, alpha-synuclein co-pathology selectively amplifies the association between amyloid and tau accumulation across all Braak stages without altering the downstream relationship between tau pathology and cognitive decline.
This study provides convergent multimodal evidence from resting-state fMRI and EEG that psychosis is characterized by a shift toward cortical hyperexcitability, evidenced by reduced Hurst exponents and aperiodic spectral exponents that align with specific molecular pathways involving GABA, potassium channels, and various neurotransmitter receptors.
By integrating large-scale human data with experimental mouse models, this study demonstrates that circadian misalignment is a conserved and modifiable driver of myopia, linking late chronotypes and disrupted light-dark cycles to abnormal eye growth through mitochondrial and hypoxia-related retinal pathways.
Using a comprehensive multimodal imaging approach, this study found no evidence for magnetite-based magnetoreceptors in the mole-rat eye, suggesting that if these animals possess a magnetic sense, it likely resides outside the eye or operates via a different mechanism.
This study establishes Hierarchical Phase-Contrast Tomography (HiP-CT) as a non-destructive, label-free reference modality that bridges the microstructural gap in human connectomics by validating its ability to resolve complex, micrometer-scale white matter fiber architectures that complement and exceed the resolution of diffusion MRI.
This study demonstrates that a novel selonsertib-eluting polymer coating on cochlear implant electrodes effectively mitigates acute tissue damage by inhibiting apoptosis and inflammation while promoting cell survival, thereby establishing a proof of concept for targeted drug delivery to improve device performance and longevity.
This paper introduces bi-cross-validation as a principled, data-driven framework for evaluating and selecting dynamic functional connectivity models in fMRI, demonstrating its ability to avoid circularity, balance model complexity with goodness-of-fit, and effectively compare static versus dynamic approaches across varying spatial dimensionalities.