958 papers
This paper reports an improved, scalable, and practical multigram-scale synthesis of the selective Nav1.7 inhibitor GDC-0310 that eliminates the need for carbon monoxide-mediated alkoxycarbonylation, utilizes readily available starting materials for key fragments, and achieves a 23.5% overall yield with 99.71% purity through optimized key transformations.
This study developed and validated an interpretable logistic regression model, supported by a web-based tool, to accurately predict in-hospital mortality in diabetic patients with congestive heart failure in the ICU using 13 key clinical predictors derived from MIMIC-IV and eICU-CRD databases.
This longitudinal and dyadic study demonstrates that higher-quality coparenting reduces adolescent behavior problems over time by lowering parenting stress, with significant actor and partner effects indicating that one parent's coparenting influences both their own and their partner's stress levels and perceptions of their child's behavior.
This paper presents the development and validation of a regional landslide forecast model for the Western Canada Sedimentary Basin, which integrates decades of infrastructure displacement data with hydroclimatic drivers to create an activity index capable of hindcasting past events and predicting future landslide risks for proactive infrastructure mitigation.
This nationwide prospective cohort study demonstrates that both baseline and dynamic changes in the frailty index significantly predict incident cardiovascular disease in middle-aged and older adults, establishing a non-linear dose-response relationship and validating a practical seven-item screening tool for primary care risk stratification.
This study demonstrates that modifying colorless polyimide surfaces with 3-aminopropyltriethoxysilane (APTES) significantly enhances the interfacial adhesion of ZnO protective coatings through multi-site bidirectional anchoring, thereby effectively preventing atomic oxygen erosion and maintaining high optical transmittance for aerospace applications.
This paper presents the first highly stable, fully fiber-integrated random fiber laser that utilizes a cooperative linear–nonlinear mechanism to generate broadly tunable, giant photon superbunching, thereby enabling efficient temporal ghost imaging and bridging macroscopic disordered-cavity dynamics with high-order photon statistics.
This study introduces a scalable, theory-grounded Agentic AI framework that rigorously evaluates the credibility of corporate SDG claims against a five-dimensional rubric, revealing that while most disclosures are partially substantive, firms often under-claim their actual sustainability engagement.
This study validates the traditional anti-inflammatory and analgesic uses of *Cassia fistula* pods by demonstrating that their ethanolic extract is non-toxic and effective in animal models, while identifying scopoletin as the key bioactive compound responsible for these effects through COX-2 inhibition confirmed by molecular docking.
Using a sample of Chinese A-share listed firms from 2008 to 2023, this study demonstrates that supply chain digitalization significantly enhances firm resilience by alleviating financing constraints and fostering value co-creation, with effects that are amplified under environmental uncertainty, information transparency, and a U-shaped influence of artificial intelligence application.