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958 papers

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Real-World Patterns of First-Line Treatment Selection After the Introduction of Enfortumab Vedotin Plus Pembrolizumab for Advanced Urothelial Carcinoma

This multicenter retrospective study reveals that in real-world clinical practice following the approval of enfortumab vedotin plus pembrolizumab (EVP) for advanced urothelial carcinoma, treatment selection is primarily driven by patient age and ECOG performance status rather than the structured EV-ineligible criteria (EVITA), with simple clinical variables outperforming composite eligibility tools in predicting non-EVP management.

Keita Ishimoto, Takuma Narita, Yuya Sekine, Masanao Shinohara, Naoki Fujita, Yohei Kawashima, Shintaro Narita, Shin Koba (…)2026-07-27
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Association of malnutrition with prognosis in patients with acute myocardial infarction undergoing percutaneous coronary intervention and standard modifiable cardiovascular risk factors

This study of 3,811 acute myocardial infarction patients undergoing percutaneous coronary intervention demonstrates that malnutrition, assessed by the Nutritional Risk Index, is significantly associated with increased risks of all-cause and cardiovascular death, particularly when combined with standard modifiable cardiovascular risk factors.

Hui Gao, Ruifeng Liu2026-07-27
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Large Submitral Left Ventricular Pseudoaneurysm Following Inferior Wall ST-Elevation Myocardial Infarction Successfully Managed with Isolated Dor Endoventricular Circular Patch Plasty: A Case Report

This case report describes the successful surgical management of a giant submitral left ventricular pseudoaneurysm, a rare complication of an inferior wall myocardial infarction, using isolated Dor endoventricular circular patch plasty in a patient who presented with worsening heart failure symptoms three months post-PCI.

Zakiur Rehman Ansari, Zainul Abedein Hamdulay, Nazir Juvale, Azizullah Khan, Sanjesh Jain, Meher Hamdulay2026-07-27
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Mapping of the pig/pork cross-border food chain between Zambia and the Democratic Republic of the Congo as a first step to assess its potential impact on the occurrence of Taenia solium in Haut Katanga Province

This study maps the largely unregulated cross-border pig and pork supply chain between Zambia and the Democratic Republic of the Congo, revealing significant gaps in veterinary oversight and health inspections that facilitate the transmission of *Taenia solium* to consumers in Haut-Katanga Province.

Alain TSHIASUMA Kedi, Gégoire Kasongo Aseke Mukanga, Moses Tshikung Kambol2026-07-27✓ Author reviewed ⓘ
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Military DrinksRation: a randomized controlled trial of a smartphone intervention to reduce alcohol consumption among regular UK Armed Forces personnel

Although the "Military DrinksRation" trial successfully identified at-risk drinking among serving UK Armed Forces personnel, it failed to generate sufficient outcome data to evaluate the smartphone intervention's effectiveness due to unexpectedly low recruitment and a complete lack of primary endpoint completion in the intervention arm.

Kate King, Daniel Leightley, Neil Greenberg, Nicola Fear2026-07-27
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Toxicity of immunosuppressive drugs on human fetal kidney development; a study using organotypic culture

This study demonstrates that while immunosuppressive drugs generally do not cause acute toxicity to human fetal kidney organotypic cultures at biologically relevant concentrations, high doses of cyclosporine significantly impair cell viability and differentiation, and all tested agents warrant further investigation regarding their potential impact on renin-positive cells and long-term renal development.

Philippine BABIN, Hugoline BOULAY, Christèle DESDOITS-LETHIMONIER, Maryne TOUPIN, Francisco Javier FERNÁNDEZ PRIETO, Lau (…)2026-07-27
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Technology modularity shapes latecomer cost convergence in renewables

This study demonstrates that technology modularity critically shapes latecomer cost convergence in renewables, revealing that emerging economies achieve faster cost reductions than developed nations in modular solar PV due to global knowledge transfer, but face slower progress in site-specific onshore wind, thereby necessitating technology-specific climate finance strategies rather than uniform global learning curves.

Jing Meng, Litiao Hu, Jack Harris, Zongwei Ma, Jun Bi2026-07-27