958 papers
Baicalein ameliorates idiopathic pulmonary fibrosis by disrupting the HIF-1α/FHL2 phase-separated transcriptional hub, thereby suppressing the hypoxia-driven glycolytic shift and subsequent lactate-mediated histone lactylation that fuel fibrotic progression.
This study demonstrates that combining liver-directed lentiviral gene therapy with transient costimulatory blockade overcomes adaptive immune barriers to achieve durable therapeutic factor VIII expression, immune tolerance, and the ability to safely redose the therapy in a mouse model of hemophilia A.
This paper proposes a robust video steganography method that combines MEC-AQIM embedding in the DWT-SVD domain with a dual-layer pseudo-noise synchronization mechanism to effectively recover secret data from videos subjected to both recompression and arbitrary cropping.
This study utilizes structural equation modeling on data from 200 respondents at Raya University to demonstrate that compensation, career development, and perceived organizational support significantly influence employee turnover intention in Ethiopian higher education institutions, both directly and indirectly through the mediating role of job satisfaction.
This study of 435 residents in Ghana's mining-affected communities reveals that while institutional trust and perceived environmental benefits significantly drive willingness to participate in illegal mining site restoration, financial contributions remain limited by income constraints and low trust, highlighting the need for governance strategies that integrate credibility with livelihood-sensitive compensation.
Using dominance analysis on a sample of 353 undergraduate students, this study identifies the impulsivity facet of emotion dysregulation as the most significant predictor of daily cannabis use, followed by the strategies and non-acceptance facets, thereby highlighting the need for targeted interventions addressing these specific components.
This study reveals that host skin lipids trigger *Malassezia furfur* pathogenicity by activating a mating-type-dependent parasexual cycle that drives hyphal differentiation, enabling more efficient epidermal invasion and stronger inflammatory responses.
This study demonstrates that withdrawing WNT3a and TGFβ inhibitors in human gastric mucosoids drives differentiation into antral gland-like compartments with enhanced barrier and secretory functions, while cAMP signaling further modulates cell states and mucus proteome composition, establishing a versatile model for studying gastric epithelial biology.
This bibliometric analysis of 802 publications from 2016 to 2025 maps the rapid evolution of organoid and organ-on-a-chip research in diabetes and cardiovascular diseases, highlighting a paradigm shift toward high-fidelity disease modeling driven by the integration of bioprinting, single-cell omics, and artificial intelligence.
This study developed and internally validated a simplified, interpretable logistic regression model based on five routine non-contrast MRI features that effectively differentiates benign from malignant ovarian tumors, offering a valuable decision-support tool for settings where contrast-enhanced imaging is unavailable or contraindicated.