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Hyperpolarized 13C MRI uncovers early and progressive metabolic dysfunction in the hAPP-J20 mouse model of Alzheimer’s disease
This study demonstrates that hyperpolarized 13C pyruvate MRI detects early, progressive, and sex-specific increases in glycolytic flux in the hAPP-J20 Alzheimer's mouse model before changes are visible on standard FDG-PET, revealing distinct metabolic rewiring patterns between males and females that underscore the technique's potential as a sensitive, radiation-free biomarker for early Alzheimer's disease.
Tamara Vasilkovska, Lydia M. Le Page, Caroline Guglielmetti, Marina Radoul, Huihui Li, Xiao Ji, Jeremy W. Gordon, Ken Na (…)2026-07-27